公开(公告)号：US20210325049A1

公开(公告)日：2021-10-21

申请号：US16972173

申请日：2019-05-23

Applicant: Younghee LEE

Inventor： Younghee LEE

IPC: F24C15/20

Abstract: A discharge device connected to an exhaust tube for discharging out fumes of a cooking chamber comprises a water reservoir, a cooling container, and a gasket. A water reservoir is provided with a water supply plug on an upper side of a body in which a space is formed to receive water. A cooling container has a body with an open upper part through which accommodates the water reservoir and a space to receive water in the lower part. An inlet pipe is formed at one side of the cooling container, and it is connected to the exhaust tube through which the fumes flows. A gasket is formed at an upper opening of the sidewalls of the cooling container for sealing a gap with the water reservoir. A number of partition walls are installed in vertical direction at the bottom of the cooling container. The fumes entering the inlet pipe are reduced in multiple stages, firstly cooled by the water reservoir while moving through a multitude of gaps and adhering to the surface, and secondly cooled and precipitated by the water in the cooling container.

公开(公告)号：US20090093479A1

公开(公告)日：2009-04-09

申请号：US12336857

申请日：2008-12-17

Applicant: Martha KELLY ,  Younghee LEE ,  Bin LIU ,  Ted FUJIMOTO ,  Joel FREUNDLICH ,  Bruce D. DORSEY ,  Gary A. FLYNN ,  Arifa HUSAIN

Inventor： Martha KELLY ,  Younghee LEE ,  Bin LIU ,  Ted FUJIMOTO ,  Joel FREUNDLICH ,  Bruce D. DORSEY ,  Gary A. FLYNN ,  Arifa HUSAIN

IPC: A61K31/5377 ,  C07D401/02 ,  C07D211/80 ,  C07D409/02 ,  C07D401/14 ,  C07D405/02 ,  A61K31/497 ,  A61K31/506 ,  A61P35/00 ,  A61K31/422 ,  A61K31/4709 ,  A61K31/4439 ,  A61K31/4436 ,  A61K31/443 ,  A61K31/44 ,  C07D413/02

CPC classification number: C07D209/08 ,  C07D213/74 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D405/10 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D417/10

Abstract: The present invention is in the area of novel compounds and salts thereof, their syntheses, and their use as anti-cancer agents. The compounds include compounds of Formula I: and solvates, hydrates and pharmaceutically-acceptable salts thereof, wherein A1 is N or CR1; A3 is N or CR3; A5 is N or CR5; R1, R3-R6 and L are defined in the specification; n is 0 or 1; and X is an optionally-substituted aryl group having 6-10 carbons in the ring portion, an optionally-substituted 6-membered heteroaryl group having 1-3 nitrogen atoms in the ring portion, an optionally-substituted 5-membered heteroaryl group having 0-4 nitrogen atoms in the ring portion and optionally having 1 sulfur atom or 1 oxygen atom in the ring portion, or an optionally-substituted heteroaryl group in which a 6-membered ring is fused either to a 5-membered ring or to a 6-membered ring, wherein in each case 1, 2, 3 or 4 ring atoms are heteroatoms independently selected from nitrogen, oxygen and sulfur. They are effective against a broad range of cancers, especially leukemia, non-small cell lung and colon.

Abstract translation: 本发明涉及新型化合物及其盐，其合成及其作为抗癌剂的用途。 化合物包括式I化合物及其溶剂合物，水合物及其药学上可接受的盐，其中A1为N或CR1; A3是N或CR3; A5为N或CR5; R1，R3-R6和L在说明书中定义; n为0或1; 并且X是在环部分中具有6-10个碳的任选取代的芳基，在环部分中具有1-3个氮原子的任选取代的6元杂芳基，任选取代的5元杂芳基具有0 -4个氮原子，并且在环部分中任选具有1个硫原子或1个氧原子，或任选取代的杂芳基，其中6元环稠合到5元环或6元环 其中在每种情况下，1,2,3或4个环原子是独立地选自氮，氧和硫的杂原子。 它们对广泛的癌症尤其是白血病，非小细胞肺和结肠有效。