公开(公告)号：US11725046B2

公开(公告)日：2023-08-15

申请号：US16958213

申请日：2018-12-28

Applicant: ZHUHAI TRINOMAB BIOTECHNOLOGY CO., LTD.

Inventor： Huaxin Liao ,  Yueming Wang ,  Xiaohui Yuan ,  Weihong Zheng

IPC: C07K16/12 ,  G01N33/569 ,  G01N33/577

CPC classification number: C07K16/1282 ,  G01N33/56911 ,  G01N33/577 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/33

Abstract: The invention describes fully native human neutralizing monoclonal antibodies against tetanus toxin. The invention developed fully native human neutralizing monoclonal antibodies against tetanus toxin through a systematic high through-put platform that is specialized for identifying and developing human native antibody. The neutralizing monoclonal antibodies described in the invention can be used in the prevention, treatment and detection of Clostridium tetani infection. The fully human neutralizing monoclonal antibodies developed in the invention have a high affinity toward tetanus toxin, as well as possessing high neutralizing activities against the toxin, safe of use with high disease prevention effectiveness, free of exogenous virus contamination, and are widely applicable to various human groups with strong industrial applications.