-
公开(公告)号：US11407787B2
公开(公告)日：2022-08-09
申请号：US16619081
申请日：2018-06-06
IPC分类号： C07K5/093
摘要： The present application discloses a crystal of oxidized glutathione dication salt and a method of producing the same.
-
公开(公告)号：US11098007B2
公开(公告)日：2021-08-24
申请号：US16311061
申请日：2017-06-23
发明人： Tomoya Yokoi , Hiroshi Nagano , Takayuki Shimizu
IPC分类号： C07C227/42 , C07C229/26 , C07C51/41 , C07C59/01 , C07C51/43 , C07C277/06 , C07C279/14
摘要： An object of the present invention is to provide a crystal of an amino acid salt of HMB which is easy to handle and has high solubility, and to provide a method for producing the same. According to the present invention, the crystal of an amino acid salt of HMB can be precipitated by dissolving an amorphous amino acid salt of HMB in a solvent containing alcohol and stirring or allowing the solvent to left stand. In addition, the crystal of an amino acid salt of HMB can be precipitated by concentrating an aqueous HMB solution of an amino acid salt which has a pH of 2.5 to 11.0.
-
公开(公告)号：US20210113601A1
公开(公告)日：2021-04-22
申请号：US17138742
申请日：2020-12-30
发明人： Kota KUMAGAI , Masahiko MORITA , Takahiro HARA , Kohji FUKUNAGA
IPC分类号： A61K31/7068 , A61K31/198
摘要： An object of the invention is to provide an agent for preventing or improving decline in brain function such as decreased perception ability, decreased memory learning ability, decreased thinking ability, decreased concentration, decreased attention, decreased judgment ability, depression, and decreased exercise performance caused thereby. According to the invention, an agent for protecting brain neuronal cells, comprising citrulline or a salt thereof and citicoline or a salt thereof as active ingredients as well as an agent for preventing or improving decline in brain function, comprising citrulline or a salt thereof and citicoline or a salt thereof as active ingredients is provided.
-
公开(公告)号：US10905705B2
公开(公告)日：2021-02-02
申请号：US14435984
申请日：2013-10-30
发明人： Kota Kumagai , Masahiko Morita , Takahiro Hara , Kohji Fukunaga
IPC分类号： A61K31/7068 , A61K31/198
摘要： An objection of the present invention is to provide an agent for preventing or improving decline in brain function such as decreased perception ability, decreased memory learning ability, decreased thinking ability, decreased concentration, decreased attention, decreased judgment ability, depression, and decreased exercise performance caused thereby. According to the present invention, an agent for protecting brain neuronal cells, comprising citrulline or a salt thereof and citicoline or a salt thereof as active ingredients as well as an agent for preventing or improving decline in brain function, comprising citrulline or a salt thereof and citicoline or a salt thereof as active ingredients is provided.
-
公开(公告)号：US10426813B2
公开(公告)日：2019-10-01
申请号：US13508163
申请日：2010-11-05
IPC分类号： A61K38/05 , A61K31/198
摘要： The present invention relates to a method of enhancing endurance of a human subject through administration of alanyl-glutamine or alanyl-glutamine salt. The invention includes unexpected discovery of alanyl-glutamine or alanyl-glutamine salt enhancing durability and endurance of human subject independent of an increase in the blood glutamine level.
-
公开(公告)号：US10370670B2
公开(公告)日：2019-08-06
申请号：US15791742
申请日：2017-10-24
发明人： Tetsuo Nakano , Eitora Yamamura
IPC分类号： A61K39/39 , C12N15/117 , C12N15/11 , A61K31/713
摘要： The invention provides a double-stranded ribonucleic acid (dsRNA) having a chain length suitable for simultaneously showing low toxicity and high function in the use of an adjuvant and the like, and resisting variation of chain length even when subjected to a heating and cooling treatment, or a salt thereof; an immune potentiator, adjuvant, pharmaceutical product and the like containing the dsRNA and the like; and a production method of such dsRNA and the like. The invention is characterized in that the weight average chain length of two or more single-stranded ribonucleic acids (ssRNAs) constituting the first chain constituting dsRNA is not more than ½ of the weight average chain length of one ssRNA constituting the second chain.
-
7.发明申请公开(公告)号：US20190177686A1
公开(公告)日：2019-06-13
申请号：US16099912
申请日：2017-05-08
IPC分类号： C12N5/074
摘要： An object of the present invention is to provide an albumin-free medium for serum-free culture of pluripotent stem cells capable of maintaining the undifferentiated state and the pluripotency (pluripotent ability) of the pluripotent stem cells, an additive for an albumin-free medium, and a culture method. The albumin-free medium for serum-free culture of pluripotent stem cells, the additive for an albumin-free medium, and a medium used for the culture method of the invention are characterized by containing at least one selected from the group consisting of a Pluronic nonionic surfactant, an animal-based hydrolysate, and a nonanimal-based hydrolysate.
-
公开(公告)号：US20190105274A1
公开(公告)日：2019-04-11
申请号：US15743138
申请日：2016-07-12
IPC分类号： A61K9/20 , A61K31/198
摘要： The invention provides a tablet that contains free-form arginine at a high content, suppresses cracking and collapse due to moisture absorption, is superior in preservation stability and permits convenient production. The tablet contains free-form arginine at a concentration of not less than 5 mass % of the total amount of the tablet and can be obtained by compression molding free-form arginine dried by a spray dry method.
-
公开(公告)号：US10252991B2
公开(公告)日：2019-04-09
申请号：US15110827
申请日：2015-01-14
IPC分类号： C12P33/00 , C07C401/00 , C07J9/00
摘要： According to the present invention, there can be provided A process for producing 7-dehydrocholesterol (hereinafter, “7DHC”), comprising culturing, in a medium, a 7DHC-producing Labyrinthulea microorganism in which the 7DHC reducing activity is reduced or lost as compared to a parent strain through deletion, substitution, or addition of at least one base in a gene which is present in the chromosomal DNA of the parent strain and encodes a protein having 7DHC reducing activity, and the microorganism produces 7DHC, allowing 7DHC to be produced and accumulated in the culture, and collecting the 7DHC from the culture; and a process for producing vitamin D3, comprising irradiating, with ultraviolet light, the 7DHC produced by the production process.
-
公开(公告)号：US20190085023A1
公开(公告)日：2019-03-21
申请号：US16083483
申请日：2017-03-10
发明人： Kazunari FUKUMOTO , Maya IGUCHI , Hiroshi NAGANO
摘要： The present invention provides a crystal of reduced glutathione having excellent powder properties and a method for producing the same. The present invention relates to a crystal of reduced glutathione, wherein the average crystal thickness is 10 μm or more.
-
-
-
-
-
-
-
-
-
搜索结果
187 条记录 (耗时 0.036 秒)