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公开(公告)号：US12049617B2
公开(公告)日：2024-07-30
申请号：US17050626
申请日：2019-05-21
申请人： DSM IP Assets B.V.
发明人： Christopher Mark Farrell , Lisa Ann Laprade , Otto Martin Lehmann , Joshua Trueheart , Bastien Jean Wolfgang Chevreux
摘要： The present invention is related to an improved method for production of 7-dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention features modified yeast strains expressing enzymes having improved C-8 sterol isomerase activity leading to increased ratios of 7-DHC in the sterol mix.
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2.发明授权公开(公告)号：US11981935B2
公开(公告)日：2024-05-14
申请号：US17150243
申请日：2021-01-15
申请人： PharmaZell GmbH
发明人： Dirk Weuster-Botz , Michael Braun , Arno Aigner , Boqiao Sun , Christina Kantzow , Sven Bresch , Daniel Bakonyi , Werner Hummel
CPC分类号： C12N9/0006 , C12N9/0008 , C12P33/00 , C12P33/02 , C12Y101/01201
摘要： In various aspects and embodiments, the invention provides a nucleic acid molecule comprising a nucleotide sequence encoding a 7β-hydroxysteroid dehydrogenase (7β-HSDH) mutant that catalyzes at least the stereospecific enzymatic reduction of a 7-ketosteroid to the corresponding 7-hydroxysteroid, wherein the mutant has, compared to the wildtype 7β-HSDH of SEQ ID NO:2, a decreased substrate inhibition and/or an altered cofactor usage, and the mutant has, in comparison with the wildtype 7β-HSDH of SEQ ID NO:2, 1 to 15 amino acid additions, substitutions, deletions and/or inversions in the sequence motif VMVGRRE corresponding to positions 36 to 42 of SEQ ID NO:2.
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公开(公告)号：US11938141B2
公开(公告)日：2024-03-26
申请号：US17455538
申请日：2021-11-18
申请人： CASSIOPEA S.P.A.
发明人： Mauro Ajani , Luigi Moro
IPC分类号： A61K31/573 , A61K9/00 , A61K9/06 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/44 , C07J5/00 , C07J7/00 , C12P33/00
CPC分类号： A61K31/573 , A61K9/0014 , A61K9/06 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/44 , C07J5/0053 , C07J7/008 , C07B2200/13 , C12P33/005
摘要： The present invention refers to a new enzymatic process for obtaining 17α-monoesters of cortexolone and/or its 9,11-dehydroderivatives starting from the corresponding 17α,21-diesters which comprises an enzymatic alcoholysis reaction. Furthermore, the present invention refers to new crystalline forms of cortexolone-17α-propionate and 9,11-dehydro-cortexolone 17α-butanoate.
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公开(公告)号：US11844365B2
公开(公告)日：2023-12-19
申请号：US15206930
申请日：2016-07-11
申请人： PureCircle Sdn Bhd
发明人： Avetik Markosyan
IPC分类号： A23L27/30 , C12P19/22 , A23C9/13 , A23L2/60 , A21D2/18 , A21D2/36 , A61K36/28 , C12P19/18 , C12P19/56 , C12P33/00 , A61K31/704 , A23L2/02 , A23L2/54 , A23L33/105
CPC分类号： A23L27/33 , A21D2/18 , A21D2/36 , A23C9/1307 , A23L2/02 , A23L2/54 , A23L2/60 , A23L27/36 , A23L33/105 , A61K31/704 , A61K36/28 , C12P19/18 , C12P19/22 , C12P19/56 , C12P33/00 , C12Y204/01019 , A23V2002/00 , Y02P20/52
摘要： Glucosyl Stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The short-chain glucosyl Stevia compositions were purified to >95% content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.
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公开(公告)号：US11162067B2
公开(公告)日：2021-11-02
申请号：US15678643
申请日：2017-08-16
发明人： Viji Sitther , Kadir Aslan , Behnam Tabatabai
摘要： Compositions including metal nano- and/or micro-particles in solution with photosynthetic bioproduct producing microorganisms. These light harvesting complexes increase growth rates and photosynthetic efficiency of the constituent microorganisms, reducing the light required for a specific production level, or increases production for a specific light level.
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公开(公告)号：US20210324439A1
公开(公告)日：2021-10-21
申请号：US17355912
申请日：2021-06-23
发明人： Andrew P. Patron , Chris Edano Noriega , Rama R. Manam , Justin Colquitt , Nathan Faber , Helge Zieler , Justin Stege
摘要： Provided herein include methods of making mogroside compounds, e.g., Compound 1, compositions (for example host cells) for making the mogroside compounds, and the mogroside compounds made by the methods disclosed herein, and compositions (for example, cell lysates) and recombinant cells comprising the mogroside compounds (e.g., Compound 1). Also provided herein are novel cucurbitadienol synthases and the use thereof.
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公开(公告)号：US11091787B2
公开(公告)日：2021-08-17
申请号：US16806812
申请日：2020-03-02
申请人： Evolva SA
发明人： Jens Houghton-Larsen , Katarzyna Krzystanek , Angelika Semmler , Iver Klavs Riishede Hansen , Soren Damkiaer , Yaoquan Liu , Jorgen Hansen , Sathish Kumar , Muthuswamy Panchapagesa Murali , Nina Nicoline Rasmussen
IPC分类号： C12P33/00 , C12P19/56 , C12P19/18 , C12N9/14 , C12N9/10 , C12N9/06 , C12N9/90 , C12N9/02 , A23L27/30 , C07H1/06 , C12N15/00
摘要： Methods for recombinant and enzymatic production of mogroside compounds and compositions containing mogroside compounds are provided by this invention.
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公开(公告)号：US11060124B2
公开(公告)日：2021-07-13
申请号：US15969616
申请日：2018-05-02
发明人： Andrew P. Patron , Chris Edano Noriega , Rama R. Manam , Justin Colquitt , Nathan Faber , Helge Zieler , Justin Stege
IPC分类号： C12P33/00 , C12P33/20 , C12N9/02 , C12N9/90 , C12P33/12 , A23L27/30 , C07J17/00 , C12N9/42 , C12P19/18 , C12P19/56
摘要： Provided herein include methods of making mogroside compounds, e.g., Compound 1, compositions (for example host cells) for making the mogroside compounds, and the mogroside compounds made by the methods disclosed herein, and compositions (for example, cell lysates) and recombinant cells comprising the mogroside compounds (e.g., Compound 1). Also provided herein are novel cucurbitadienol synthases and the use thereof.
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公开(公告)号：US20210130858A1
公开(公告)日：2021-05-06
申请号：US16866877
申请日：2020-05-05
发明人： Scott Franklin , Aravind Somanchi , George Rudenko , Riyaz Bhat , Xinhua Zhao , Risha Bond , Walter Rakitsky , Alejandro Marangoni , Diza Braksmayer
IPC分类号： C12P7/64 , C12N9/02 , C12N9/10 , C12N9/16 , A23D9/013 , C11B1/00 , A23D9/00 , C07C57/03 , C07J9/00 , C12P33/00 , C12N15/82 , C12N9/24 , C12N15/113
摘要： Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desaturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.
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公开(公告)号：US10544441B2
公开(公告)日：2020-01-28
申请号：US15314155
申请日：2015-06-24
申请人： Pharmazell GmbH
发明人： Dirk Weuster-Botz , Boqiao Sun , Christian Quirin
摘要： The invention relates to novel biocatalytic processes comprising the whole cell reduction of dehydrocholic acid (DHCA) compounds, novel 7β-hydroxy steroid dehydrogenase mutants, the sequences coding for these enzyme mutants, methods for producing the enzyme mutants and use thereof in enzymatic conversions of cholic acid compounds, and in particular in the production of ursodesoxycholic acid (UDCA); also a subject of the invention are novel methods for the synthesis of UDCA using the enzyme mutants; and in particular a further improved method for producing UDCA using recombinant whole cell biocatalysts.
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