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91.发明授权公开(公告)号：US11529122B2
公开(公告)日：2022-12-20
申请号：US16726089
申请日：2019-12-23
申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education , The Regents of the University of Michigan
发明人： Kang Kim , Jingping Xu , Jonathan M Rubin
摘要： A method of evaluating tissue stiffness of a target area includes positioning an ultrasound elasticity imaging apparatus adjacent a surface of an area of tissue where the target area is located and applying a dynamic range of force to the tissue. A plurality of ultrasound beams can be directed at the tissue and a plurality of ultrasound echoes can be acquired from the strained tissue in the target area to calculate an amount of developed strain within the target area.
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公开(公告)号：US20220395612A1
公开(公告)日：2022-12-15
申请号：US17872467
申请日：2022-07-25
摘要： The present invention relates to an ovarian-derived hydrogel material, which can be useful for three-dimensional in vitro culturing of cells, cell therapy, fertility preservation, drug delivery, site-specific remodeling and repair of damaged tissue, and/or diagnostic kits.
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公开(公告)号：US11517234B2
公开(公告)日：2022-12-06
申请号：US15956461
申请日：2018-04-18
发明人： Xinyan Cui , Nicolas Alexander Alba , Mingui Sun
摘要： An electrode system include a flowable and cohesive surface contact element comprising a hydrophilic polymer swollen with an electrolyte fluid, the contact element having a Q′ ratio of at least 5 as defined by the equation Q ′ = W W W G wherein WG is the dry weight of the hydrophilic polymer and WW is weight of water in the sample after absorption of the electrolyte fluid comprising water and an electrolyte salt. The surface contact element can consist essentially of the hydrophilic polymer swollen by the electrolyte fluid. Another electrode system includes a contact element including a crosslinked hydrophilic polymer matrix. The contact element has a Q′ ratio of at least 5 as defined by the equation Q ′ = W W W G . The contact elements can also have a Q′ ratio of at least 6, at least 7, at least 10 or even at least 11.
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公开(公告)号：US11513100B2
公开(公告)日：2022-11-29
申请号：US16479675
申请日：2018-01-26
申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , UNITED STATES DEPARTMENT OF ENERGY
摘要： A gas sensor (100,200) includes at least one sensor device including a surface acoustic wave (SAW) device (110) or a quartz crystal microbalance (QCM) device (210), and a layer of metal organic framework (MOF) material (120,220) disposed on each of the at least one sensor device. The at least one sensor device is structured to sense a change in mass of the MOF material.
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公开(公告)号：US20220364449A1
公开(公告)日：2022-11-17
申请号：US17734713
申请日：2022-05-02
申请人： Chevron U.S.A. Inc. , University of Pittsburgh - Of the Commonwealth System of Higher Education
摘要： A dissipation equilibrium value for a well operation may be determined based on a height of a fracture within a layer and a limit on the change of the height of the fracture (fracture height change limit). A pressure limit for the well operation may be determined based on the dissipation equilibrium value, stress in the layer, and stress in a bounding layer. The pressure limit may be used to control the pressure of the well during the well operation, and prevent growth of the fracture beyond the fracture height change limit.
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公开(公告)号：US20220362340A1
公开(公告)日：2022-11-17
申请号：US17773373
申请日：2020-10-30
申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , WISCONSIN ALUMNI RESEARCH FOUNDATION
IPC分类号： A61K38/20 , A61K35/747 , A61K35/741 , A61K38/21 , A61K38/19 , A61K31/4184 , A61K31/4468 , A61K31/4178 , A61K31/352 , A61K31/341 , A61P1/00
摘要： Disclosed herein are gastrointestinal tract (G1) bacteria and methods for treating or preventing an irradiation-induced intestinal damage in a subject, the methods comprising administering a G1 bacterium to the subject, wherein the G1 bacterium comprises a vector that comprises a polynucleotide encoding IL-22 and/or IFN-P, or a functional fragment thereof.
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公开(公告)号：US20220355540A1
公开(公告)日：2022-11-10
申请号：US17621115
申请日：2020-06-22
IPC分类号： B29C64/129 , B33Y10/00
摘要： A four-dimensional (“4D”)-printing or 4D-additive manufacturing method for producing anisotropic macroscopic structures and/or anisotropic macroscopic materials having a plurality of voxels, comprising: providing or forming a first layer of a photocurable first liquid crystalline (LC) monomer; wherein the first layer of the first LC monomer has been provided or formed at a temperature falling within a nematic phase range of the first LC monomer; applying a magnetic field, having a first three-dimensional (“3D”) magnetic field vector with respect to an origin point of a 3D coordinate system, to the first layer of first LC monomer or one or more of the plurality of voxels within the first layer of first LC monomer for a first dwell time, to produce in alignment with the first 3D magnetic field vector a first molecular director and/or first nematic alignment vector within the first layer of first LC monomer or within each of the one or more of the plurality of voxels within the first layer of first LC monomer; exposing the first layer of first LC monomer or the one or more of the plurality of voxels within the first layer of first LC monomer to a first dose of light radiation.
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公开(公告)号：US20220346908A1
公开(公告)日：2022-11-03
申请号：US17862078
申请日：2022-07-11
发明人： Jeffrey S. Vipperman , Christopher Michael Dumm , Garth Abraham Elias , Tyler Michael Ferris , Mark Scaife , Peter David Allen
IPC分类号： A61B90/50 , A61B34/00 , A61B90/30 , A61B90/35 , A61B90/00 , A61B90/57 , A61B17/00 , A61B17/02
摘要： Disclosed adjustable retaining arm systems can include a multi-segmented, articulable arm that holds one or more interchangeable tools and can be made relaxed to set a desired position and made rigid to fix the desired position by adjusting tension in a cable running through the arm. The arm can quickly attach and detach from a support structure. The support structure include a cable tensioning system, sensors, control system, power system, etc. A user input device, such as a foot pedal or button on the arm, can be used by a surgeon to change the arm between relaxed and rigid states. The arm and attachable tools can be detachable, disposable and/or sterilizable, while other system components can remain mounted in a fixed location as the arm is removed and replaced. The arm can hold multiple tools in any desired orientation around subject work location.
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公开(公告)号：US11484532B2
公开(公告)日：2022-11-01
申请号：US16631422
申请日：2018-07-13
发明人： Yan Xu , Pei Tang , Marta Megan Wells
IPC分类号： A61K31/452 , A61P25/36 , A61P25/04 , A61K31/166 , A61K31/485 , A61K31/495 , A61K45/06
摘要： Compounds and methods for modulating the activity of receptors are disclosed. Some of the compounds modulate the activity of glycine receptors. Certain embodiments of the compounds are useful for treatment of pain, treatment of opioid addiction, and/or reduction of side effects attributable to opioid use.
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公开(公告)号：US20220332812A1
公开(公告)日：2022-10-20
申请号：US17641044
申请日：2020-09-10
摘要： A method of inhibiting neutrophil activation in retinal pigment epithelial (RPE) cells comprising administering an inhibitor of interferon (IFN) λ to a subject in need thereof, as well as a method of restoring lysosomal function of RPE cells comprising administering a polypeptide comprising βA1-crystallin or a nucleic acid encoding the polypeptide to a subject in need thereof, are provided. A method of rejuvenating Vacuolar-type H+-ATPase (V-ATPase) activity in RPE cells by modulating assembly and disassembly of the V-ATPase in a subject in need thereof also is provided. Additionally, a method of treating diabetic retinopathy in a subject comprising administering a polypeptide comprising βA1-crystallin or a nucleic acid encoding the polypeptide to the subject is provided.
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