公开(公告)号：US06706065B2

公开(公告)日：2004-03-16

申请号：US09909193

申请日：2001-07-19

申请人： Jonathan J. Langberg ,  Michael D. Lesh

发明人： Jonathan J. Langberg ,  Michael D. Lesh

IPC分类号： A61F206

CPC分类号： A61F2/2451 ,  A61F2/2466 ,  A61N2001/0585

摘要： A left ventricle restriction device is designed to be transvenously advanced and deployed within the coronary sinus and in some embodiments other coronary veins. The device places tension on adjacent structures, reducing the diameter and/or limiting diastolic expansion of the left ventricle. This may be beneficial for patients with dilated cardiomyopathy.

摘要翻译： 左心室限制装置被设计成在冠状窦内部和在一些实施例中是其他冠状静脉中被递送和部署。 该装置在相邻结构上施加张力，减小左心室的直径和/或限制舒张期扩张。 这可能对扩张型心肌病患者有益。

公开(公告)号：US06514249B1

公开(公告)日：2003-02-04

申请号：US09517472

申请日：2000-03-02

申请人： Mark A. Maguire ,  Martin F. O'Sullivan ,  Edward L. Carcamo ,  Michael D. Lesh ,  Alan K. Schaer ,  Kevin J. Taylor ,  Guillermo P. Picazo

发明人： Mark A. Maguire ,  Martin F. O'Sullivan ,  Edward L. Carcamo ,  Michael D. Lesh ,  Alan K. Schaer ,  Kevin J. Taylor ,  Guillermo P. Picazo

IPC分类号： A61B1818

CPC分类号： A61N7/02 ,  A61B18/00 ,  A61B18/1492 ,  A61B2017/00106 ,  A61B2017/00243 ,  A61B2018/00214 ,  A61B2018/00261

摘要： This invention relates to a surgical device and method. More particularly, it relates to a tissue ablation device assembly and method using a circumferential ablation member in combination with a position monitoring assembly in order to position the circumferential ablation member along a circumferential region of tissue at a location where a pulmonary vein extends from a left atrium.

摘要翻译： 本发明涉及一种手术装置和方法。 更具体地，本发明涉及一种组织消融装置组件和使用周边消融部件与位置监测组件组合的方法，以便沿着肺静脉从左侧延伸的位置沿着组织的周边区域定位周边消融部件 心房

公开(公告)号：US06458100B2

公开(公告)日：2002-10-01

申请号：US09904959

申请日：2001-07-13

申请人： Chad C. Roue ,  Andrew G. C. Frazier ,  Michael D. Lesh ,  Erik J. van der Burg

发明人： Chad C. Roue ,  Andrew G. C. Frazier ,  Michael D. Lesh ,  Erik J. van der Burg

IPC分类号： A61M2900

CPC分类号： A61B17/0057 ,  A61B17/00234 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/0644 ,  A61B17/12122 ,  A61B2017/00243 ,  A61B2017/00292 ,  A61B2017/00575 ,  A61B2017/00579 ,  A61B2017/00632 ,  A61B2017/00668 ,  A61B2017/0409 ,  A61B2017/0412 ,  A61B2017/0414 ,  A61B2017/0417 ,  A61B2017/042 ,  A61B2017/0437 ,  A61B2017/0445 ,  A61B2017/0454 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0472 ,  A61B2017/0477 ,  A61B2017/048 ,  A61B2017/0488 ,  A61B2017/0645 ,  A61B2017/0647 ,  A61F2/24 ,  A61F2/2427 ,  A61F2/2487 ,  Y10S606/907

摘要： Disclosed is a closure catheter, for closing a tissue opening such as an atrial septal defect, patent foreman ovale, or the left atrial appendage of the heart. The closure catheter carries a plurality of tissue anchors, which may be deployed into tissue surrounding the opening, and used to draw the opening closed. Methods are also disclosed.

摘要翻译： 公开了一种封闭导管，用于封闭组织开口，例如房间隔缺损，专利前额卵巢或心脏的左心耳。 闭合导管携带多个组织锚，其可以部署在围绕开口的组织中，并用于将开口拉开。 还公开了方法。

公开(公告)号：US06402781B1

公开(公告)日：2002-06-11

申请号：US09494233

申请日：2000-01-31

申请人： Jonathan J. Langberg ,  Michael D. Lesh

发明人： Jonathan J. Langberg ,  Michael D. Lesh

IPC分类号： A61F206

CPC分类号： A61F2/2451 ,  A61F2/2466 ,  A61N2001/0585

摘要： A mitral annuloplasty and LV restriction device is designed to be transvenously advanced and deployed within the coronary sinus and in some embodiments other coronary veins. The device places tension on adjacent structures, reducing the diameter and/or limiting expansion of the mitral annulus and/or limiting diastolic expansion of the left ventricle. These effects may be beneficial for patients with dilated cardiomyopathy.

摘要翻译： 二尖瓣瓣成形术和LV限制装置被设计成在冠状窦内部和在一些实施例中是其他冠状静脉中经过递送和部署。 该装置在相邻结构上施加张力，减小二尖瓣环的直径和/或限制扩张和/或限制左心室的舒张期扩张。 这些影响可能对扩张型心肌病患者有益。

公开(公告)号：US06305378B1

公开(公告)日：2001-10-23

申请号：US09384727

申请日：1999-08-27

申请人： Michael D. Lesh

发明人： Michael D. Lesh

IPC分类号： A61B1900

CPC分类号： A61B18/10 ,  A61B18/08 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2017/00243 ,  A61B2017/22038 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00011 ,  A61B2018/00083 ,  A61B2018/00107 ,  A61B2018/00148 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00369 ,  A61B2018/00375 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00839 ,  A61B2018/00898 ,  A61B2018/00994 ,  A61B2018/1407 ,  A61B2218/002 ,  A61M25/1002 ,  A61M2025/1075 ,  A61M2210/125 ,  A61N7/022

摘要： This invention is a method for treating a patient diagnosed with atrial arrhythmia by forming a circumferential conduction block along a circumferential path of tissue in a pulmonary vein wall that circumscribes the pulmonary vein lumen and transects the electrical conductivity of the pulmonary vein such that conduction is blocked along the longitudinal axis of the vein wall and into the left atrial wall. The method is performed to treat a patient with a focal arrythmogenic origin along the pulmonary vein wall by either ablating the focal origin or by isolating the focal origin from the atrial wall with the circumferential conduction block. The circumferential conduction block is also formed in a pulmonary vein in order to bridge the adjacent ends of two linear lesions, wherein each linear lesion is formed to extend between the pulmonary vein and another adjacent pulmonary vein in a less-invasive “maze”-type procedure. A circumferential ablation element in a circumferential ablation device assembly is used in a percutaneous translumenal catheter technique in order to form the circumferential conduction block in the pulmonary vein wall.

摘要翻译： 本发明是一种通过沿着肺静脉壁的肺组织周向路径形成圆周传导阻滞来诊断患有心律失常的患者的方法，所述肺静脉壁围绕肺静脉管腔并横切肺静脉的导电性从而导致阻塞 沿着静脉壁的纵向轴线并进入左心房壁。 执行该方法以通过消融焦点来源或通过用圆周传导阻滞来将心源起点与心房壁一起沿着肺静脉壁治疗具有局灶性原发性起源的患者。 圆周传导阻滞也形成在肺静脉中以便桥接两个线性损伤的相邻端，其中每个线性病变形成为在较小侵入性“迷宫”型的肺静脉和另一相邻的肺静脉之间延伸 程序。 在经皮腔内导管技术中使用周缘消融装置组件中的圆周消融元件，以便在肺静脉壁中形成圆周传导阻滞。

公开(公告)号：US06254599B1

公开(公告)日：2001-07-03

申请号：US09273815

申请日：1999-03-22

申请人： Michael D. Lesh ,  Michael Ronald Ross ,  Jonathan J. Langberg ,  James C. Peacock, III

发明人： Michael D. Lesh ,  Michael Ronald Ross ,  Jonathan J. Langberg ,  James C. Peacock, III

IPC分类号： A61B1818

CPC分类号： A61B18/1492 ,  A61B18/00 ,  A61B18/1815 ,  A61B2017/00243 ,  A61B2017/22038 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00011 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00369 ,  A61B2018/00375 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00839 ,  A61B2018/00898 ,  A61B2018/00994 ,  A61B2218/002 ,  A61N7/02

摘要： This invention is a circumferential ablation device assembly which is adapted to forming a circumferential conduction block in a pulmonary vein. The assembly includes a circumferential ablation element which is adapted to ablate a circumferential region of tissue along a pulmonary vein wall which circumscribes the pulmonary vein lumen, thereby transecting the electrical conductivity of the pulmonary vein against conduction along its longitudinal axis and into the left atrium. The circumferential ablation element includes an expandable member with a working length that is adjustable from a radially collapsed position to a radially expanded position. An equatorial band circumscribes the outer surface of the working length and is adapted to ablate tissue adjacent thereto when actuated by an ablation actuator. The equatorial band has a length relative to the longitudinal axis of the expandable member that is narrow relative to the working length, and is also substantially shorter than its circumference when the working length is in the radially expanded position. A pattern of insulators may be included over an ablation element which otherwise spans the working length in order to form the equatorial band described. The expandable member is also adapted to conform to the pulmonary vein in the region of its ostium, such as by providing a great deal of radial compliance or by providing a taper along the working length which has a distally reducing outer diameter. A linear ablation element is provided adjacent to the circumferential ablation element in a combination assembly which is adapted for use in a less-invasive “maze”-type procedure in the region of the pulmonary vein ostia in the left ventricle.

公开(公告)号：US5868680A

公开(公告)日：1999-02-09

申请号：US936083

申请日：1997-09-23

申请人： Paul R. Steiner ,  Michael D. Lesh

发明人： Paul R. Steiner ,  Michael D. Lesh

IPC分类号： G06F17/00 ,  A61B5/046 ,  A61B5/0402

CPC分类号： A61B5/0464

摘要： Described is a method for monitoring the spatiotemporal organization of atrial arrhythmias, especially atrial fibrillation, based on an analysis of sequences of activation patterns obtained from a particular set of atrial recording sites. This analysis measures the degree of order change in the sequence of activation patterns, or of the time between order changes. Electrogram signals produced by atrial fibrillation are acquired simultaneously from sites adjacent to atrial tissue using multipole electrode catheters. These signals subsequently are filtered and processed to obtain a group of time series which manifest peaks at the latencies of maximal energy in the original data; when these peaks occur are the latencies that are defined as activation events. The activation events from each sampled site are ordered with respect to activation events from each of the other sites, and are translated into corresponding activation patterns, which are determined by the specific spatiotemporal activation sequence associated with each activation event. Each activation pattern in the sequence then is compared with subsequent observed patterns to determine if any spatiotemporal order change has occurred, and if so, to what extent; also, the distribution of observed activation patterns is evaluated for an additional characterization of atrial fibrillation.

摘要翻译： 描述了基于从一组特定的心房记录位点获得的激活模式序列的分析来监测房性心律失常的时空组织，特别是心房颤动的方法。 该分析测量激活模式序列或订单变化之间的时间顺序变化程度。 使用多极电极导管，同时从与心房组织相邻的部位获得由心房颤动产生的电图信号。 这些信号随后被过滤和处理以获得一组时间序列，其在原始数据中以最大能量的延迟表示峰值; 发生这些峰值时，定义为激活事件的延迟。 来自每个采样站点的激活事件相对于来自每个其他站点的激活事件被排序，并且被转换成相应的激活模式，其由与每个激活事件相关联的特定时空激活序列确定。 然后将序列中的每个激活模式与随后的观察模式进行比较，以确定是否发生了任何时空顺序变化，如果是，则在多大程度上; 还观察观察到的激活模式的分布，以评估心房颤动的额外特征。