公开(公告)号：US11276170B2

公开(公告)日：2022-03-15

申请号：US17305328

申请日：2021-07-05

Applicant: CLEERLY, INC.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques ,  Ben Hootnick

IPC: G06K9/00 ,  G06T7/00 ,  A61B8/14 ,  A61B6/00 ,  A61B6/03 ,  A61B5/00 ,  A61B8/12 ,  G06K9/62 ,  A61B5/055 ,  A61K49/04

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US11113811B2

公开(公告)日：2021-09-07

申请号：US17213813

申请日：2021-03-26

Applicant: CLEERLY, INC.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques

IPC: G06T7/00 ,  A61B8/14 ,  A61B6/00 ,  G06K9/62 ,  A61B5/055 ,  A61B6/03 ,  A61B5/00 ,  A61B8/12 ,  A61K49/04

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, a normalization device is configured to facilitate normalization of medical images of a coronary region of a subject for an algorithm-based medical imaging analysis. The normalization device can include a substrate and a plurality of compartments positioned within the substrate, each of the plurality of compartments configured to hold a sample of a known material. A first subset of the plurality of compartments can hold at least one sample of a contrast material, a second subset of the plurality of compartments can hold samples of materials representative of materials to be analyzed by the algorithm-based medical imaging analysis, and a third subset of the plurality of compartments hold at least one sample of a phantom material.

公开(公告)号：US11094061B1

公开(公告)日：2021-08-17

申请号：US17214032

申请日：2021-03-26

Applicant: CLEERLY, INC.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques

IPC: G06K9/00 ,  A61B5/02 ,  G06T7/00 ,  A61B8/14 ,  A61B6/00 ,  A61B6/03 ,  A61B5/00 ,  A61B8/12 ,  G06K9/62 ,  A61B5/055 ,  A61K49/04

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US10813612B2

公开(公告)日：2020-10-27

申请号：US16750278

申请日：2020-01-23

Applicant: Cleerly, Inc.

Inventor： James K. Min

IPC: A61B6/00 ,  A61B6/03 ,  G06T7/00

Abstract: A method for characterization of coronary plaque tissue data and perivascular tissue data using image data gathered from a computed tomography (CT) scan along a blood vessel, the image information including radiodensity values of coronary plaque and perivascular tissue located adjacent to the coronary plaque, the method comprising quantifying radiodensity in regions of coronary plaque, quantifying, radiodensity in at least one region of corresponding perivascular tissue adjacent to the coronary plaque, determining gradients of the quantified radiodensity values within the coronary plaque and the quantified radiodensity values within the corresponding perivascular tissue, and determining a ratio of the quantified radiodensity values within the coronary plaque and the corresponding perivascular tissue; and characterizing the coronary plaque by analyzing a gradient of the quantified radiodensity values in the coronary plaque and the corresponding perivascular, and/or the ratio of the coronary plaque radiodensity values and the radiodensity values of the corresponding perivascular tissue.

公开(公告)号：US20250120663A1

公开(公告)日：2025-04-17

申请号：US18989916

申请日：2024-12-20

Applicant: Cleerly, Inc.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques ,  Ben Hootnick

IPC: A61B6/00 ,  A61B5/00 ,  A61B5/02 ,  A61B5/055 ,  A61B6/03 ,  A61B6/50 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06T7/00 ,  G06V10/20 ,  G06V10/24 ,  G06V10/74 ,  G06V10/764 ,  G06V40/14

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US20240312018A1

公开(公告)日：2024-09-19

申请号：US18674711

申请日：2024-05-24

Applicant: Cleerly, Inc.

Inventor： James K. Min

IPC: G06T7/00 ,  A61B6/00 ,  A61B6/02 ,  A61B6/03 ,  A61B6/42 ,  A61B6/50 ,  G06T5/60 ,  G06T7/62 ,  G06V10/766 ,  G16H30/40 ,  G16H50/30

CPC classification number: G06T7/0014 ,  A61B6/027 ,  A61B6/035 ,  A61B6/4241 ,  A61B6/504 ,  A61B6/5217 ,  G06T5/60 ,  G06T7/62 ,  G16H30/40 ,  G16H50/30 ,  G06T2207/10081 ,  G06T2207/20021 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30048 ,  G06T2207/30101 ,  G06V10/766

Abstract: This application is directed to systems, methods, and devices for image based analysis of plaque. In some embodiments, the approaches herein can be used for developing treatment plans, which can include local treatment, systemic treatment, or both. In some embodiments, the approaches herein can be used for stent selection. In some embodiments, the approaches herein can be used for surgical planning, which can include robotic surgical planning. In some embodiments, the approaches herein can be used for image normalization. In some embodiments, the approaches herein can be used for identifying plaque calcification thresholds. In some embodiments, the approaches herein can be used for identifying thin cap fibroatheroma. In some embodiments, the approaches herein can be used for coronary artery tree reconstruction. Some embodiments are directed to coronary artery disease risk stratification.

公开(公告)号：US20240266067A1

公开(公告)日：2024-08-08

申请号：US18614597

申请日：2024-03-22

Applicant: Cleerly, Inc.

Inventor： James K. Min ,  James P. Earls ,  Shant Malkasian ,  Hugo Miguel Rodrigues Marques ,  Chung Chan ,  Shai Ronen

IPC: G16H50/30 ,  A61B5/00 ,  A61B5/02 ,  G06T7/00 ,  G06T7/10 ,  G06T7/60 ,  G06V20/50 ,  G16H30/40

CPC classification number: G16H50/30 ,  A61B5/02028 ,  A61B5/4848 ,  G06T7/0016 ,  G06T7/10 ,  G06T7/60 ,  G06V20/50 ,  G16H30/40 ,  G06T2207/10048 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/10116 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30101 ,  G06V2201/031

Abstract: Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

公开(公告)号：US20240266065A1

公开(公告)日：2024-08-08

申请号：US18614592

申请日：2024-03-22

Applicant: Cleerly, Inc.

Inventor： James K. Min ,  James P. Earls ,  Shant Malkasian ,  Hugo Miguel Rodrigues Marques ,  Chung Chan ,  Shai Ronen

IPC: G16H50/30 ,  A61B5/00 ,  A61B5/02 ,  G06T7/00 ,  G06T7/10 ,  G06T7/60 ,  G06V20/50 ,  G16H30/40

CPC classification number: G16H50/30 ,  A61B5/02028 ,  A61B5/4848 ,  G06T7/0016 ,  G06T7/10 ,  G06T7/60 ,  G06V20/50 ,  G16H30/40 ,  G06T2207/10048 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/10116 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30101 ,  G06V2201/031

Abstract: Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

公开(公告)号：US20240252133A1

公开(公告)日：2024-08-01

申请号：US18593412

申请日：2024-03-01

Applicant: Cleerly, Inc.

Inventor： James K. Min

IPC: A61B6/00 ,  A61B6/03 ,  A61B6/50 ,  G06T7/00 ,  G06T7/62 ,  G06V10/22 ,  G06V10/26 ,  G16H30/40 ,  G16H50/20

CPC classification number: A61B6/5217 ,  A61B6/032 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  A61B6/5229 ,  G06T7/0012 ,  G06T7/62 ,  G06V10/22 ,  G06V10/26 ,  G16H30/40 ,  G16H50/20 ,  G06T2207/10081 ,  G06T2207/20076 ,  G06T2207/30048 ,  G06T2207/30104 ,  G06V2201/031

Abstract: Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

公开(公告)号：US20240233955A1

公开(公告)日：2024-07-11

申请号：US18614601

申请日：2024-03-22

Applicant: Cleerly, Inc.

Inventor： James K. Min ,  James P. Earls ,  Shant Malkasian ,  Hugo Miguel Rodrigues Marques ,  Chung Chan ,  Shai Ronen

IPC: G16H50/30 ,  A61B5/00 ,  A61B5/02 ,  G06T7/00 ,  G06T7/10 ,  G06T7/60 ,  G06V20/50 ,  G16H30/40

CPC classification number: G16H50/30 ,  A61B5/02028 ,  A61B5/4848 ,  G06T7/0016 ,  G06T7/10 ,  G06T7/60 ,  G06V20/50 ,  G16H30/40 ,  G06T2207/10048 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/10116 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30101 ,  G06V2201/031

Abstract: Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.