公开(公告)号：US20240239866A1

公开(公告)日：2024-07-18

申请号：US18433929

申请日：2024-02-06

Applicant: Immatics Biotechnologies GmbH

Inventor： Jens HUKELMANN ,  Heiko SCHUSTER ,  Lena WULLKOPF ,  Christoph SCHRAEDER ,  Jens FRITSCHE ,  Daniel Johannes KOWALEWSKI ,  Michael ROEMER ,  Oliver SCHOOR

IPC: C07K14/725 ,  A61K35/17 ,  A61K38/00 ,  C07K14/74 ,  C07K16/28

CPC classification number: C07K14/7051 ,  A61K35/17 ,  C07K14/70539 ,  C07K16/2833 ,  A61K38/00 ,  C07K2319/30

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240158461A1

公开(公告)日：2024-05-16

申请号：US18421972

申请日：2024-01-24

Applicant: Immatics Biotechnologies GmbH

Inventor： Jens HUKELMANN ,  Heiko SCHUSTER ,  Lena WULLKOPF ,  Christoph SCHRAEDER ,  Jens FRITSCHE ,  Daniel Johannes KOWALEWSKI ,  Michael ROEMER ,  Oliver SCHOOR

IPC: C07K14/725 ,  A61K35/17 ,  C07K14/74 ,  C07K16/28

CPC classification number: C07K14/7051 ,  A61K35/17 ,  C07K14/70539 ,  C07K16/2833 ,  A61K38/00

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240150430A1

公开(公告)日：2024-05-09

申请号：US18417946

申请日：2024-01-19

Applicant: Immatics Biotechnologies GmbH

Inventor： Jens HUKELMANN ,  Heiko SCHUSTER ,  Lena WULLKOPF ,  Christoph SCHRAEDER ,  Jens FRITSCHE ,  Daniel Johannes KOWALEWSKI ,  Michael ROEMER ,  Oliver SCHOOR

IPC: C07K14/725 ,  A61K35/17 ,  C07K14/74 ,  C07K16/28

CPC classification number: C07K14/7051 ,  A61K35/17 ,  C07K14/70539 ,  C07K16/2833 ,  A61K38/00

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240132570A1

公开(公告)日：2024-04-25

申请号：US18404511

申请日：2024-01-04

Applicant: Immatics Biotechnologies GmbH

Inventor： Jens HUKELMANN ,  Heiko SCHUSTER ,  Lena WULLKOPF ,  Christoph SCHRAEDER ,  Jens FRITSCHE ,  Daniel Johannes KOWALEWSKI ,  Michael ROEMER ,  Oliver SCHOOR

IPC: C07K14/725 ,  A61K35/17 ,  C07K14/74 ,  C07K16/28

CPC classification number: C07K14/7051 ,  A61K35/17 ,  C07K14/70539 ,  C07K16/2833 ,  A61K38/00

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240075119A1

公开(公告)日：2024-03-07

申请号：US18472429

申请日：2023-09-22

Applicant: Immatics Biotechnologies GmbH

Inventor： Jens HUKELMANN ,  Heiko SCHUSTER ,  Ricarda HANNEN ,  Christoph SCHRAEDER ,  Jens FRITSCHE ,  Franziska HOFFGAARD ,  Daniel Johannes KOWALEWSKI ,  Oliver SCHOOR

IPC: A61K39/00 ,  A61P35/00 ,  C07K14/705 ,  C07K14/74

CPC classification number: A61K39/0011 ,  A61P35/00 ,  C07K14/705 ,  C07K14/70539 ,  A61K39/00 ,  A61K2039/5158

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 102, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240052054A1

公开(公告)日：2024-02-15

申请号：US18483174

申请日：2023-10-09

Applicant: Immatics Biotechnologies GmbH

Inventor： Meike HUTT ,  Felix UNVERDORBEN ,  Sebastian BUNK ,  Dominik MAURER ,  Martin HOFMANN ,  Gabriele PSZOLLA ,  Sara YOUSEF ,  Claudia WAGNER ,  Frank SCHWOEBEL ,  Heiko SCHUSTER

IPC: C07K16/30 ,  C07K14/725 ,  A61P35/00

CPC classification number: C07K16/30 ,  C07K14/7051 ,  A61P35/00 ,  C07K2317/32 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/567 ,  C07K2317/92 ,  C07K2317/55 ,  C07K2317/565

Abstract: The present invention concerns antigen binding proteins specifically binding melanoma associated antigen A (MAGE-A) protein-derived antigens. The invention in particular provides antigen binding proteins which specifically bind to the MAGE-A antigenic peptide comprising or consisting of SEQ ID NO: 1 in a complex with a major histocombatibility (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said MAGE-A peptide/MHC complex. The antigen binding proteins of the invention are of use for the diagnosis, treatment and prevention of MAGE-A expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

公开(公告)号：US20240024441A1

公开(公告)日：2024-01-25

申请号：US18455686

申请日：2023-08-25

Applicant: Immatics Biotechnologies GmbH

Inventor： Jens HUKELMANN ,  Heiko SCHUSTER ,  Ricarda HANNEN ,  Christoph SCHRAEDER ,  Jens FRITSCHE ,  Franziska HOFFGAARD ,  Daniel Johannes KOWALEWSKI ,  Oliver SCHOOR

IPC: A61K39/00 ,  C07K7/06 ,  A61K39/39

CPC classification number: A61K39/0011 ,  C07K7/06 ,  A61K39/39 ,  A61K2039/55533 ,  A61K2039/55527 ,  A61K2039/6093

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 102, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240024440A1

公开(公告)日：2024-01-25

申请号：US18448260

申请日：2023-08-11

Applicant: Immatics Biotechnologies GmbH

Inventor： Jens HUKELMANN ,  Heiko SCHUSTER ,  Ricarda HANNEN ,  Christoph SCHRAEDER ,  Jens FRITSCHE ,  Franziska HOFFGAARD ,  Daniel Johannes KOWALEWSKI ,  Oliver SCHOOR

IPC: A61K39/00 ,  A61P35/00 ,  C07K14/705 ,  C07K14/74

CPC classification number: A61K39/0011 ,  A61P35/00 ,  C07K14/705 ,  C07K14/70539 ,  A61K39/00 ,  A61K2039/5158

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 102, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240016907A1

公开(公告)日：2024-01-18

申请号：US18448017

申请日：2023-08-10

Applicant: Immatics Biotechnologies GmbH

Inventor： Jens HUKELMANN ,  Heiko SCHUSTER ,  Ricarda HANNEN ,  Christoph SCHRAEDER ,  Jens FRITSCHE ,  Franziska HOFFGAARD ,  Daniel Johannes KOWALEWSKI ,  Oliver SCHOOR

IPC: A61K39/00 ,  A61P35/00 ,  C07K14/705 ,  C07K14/74

CPC classification number: A61K39/0011 ,  A61P35/00 ,  C07K14/705 ,  C07K14/70539 ,  A61K39/00 ,  A61K2039/5158

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 102, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230414734A1

公开(公告)日：2023-12-28

申请号：US18458225

申请日：2023-08-30

Applicant: Immatics Biotechnologies GmbH

Inventor： Jens HUKELMANN ,  Heiko SCHUSTER ,  Ricarda HANNEN ,  Christoph SCHRAEDER ,  Jens FRITSCHE ,  Franziska HOFFGAARD ,  Daniel Johannes KOWALEWSKI ,  Oliver SCHOOR

IPC: A61K39/00 ,  A61P35/00 ,  C07K14/705 ,  C07K14/74

CPC classification number: A61K39/0011 ,  A61P35/00 ,  C07K14/705 ,  C07K14/70539 ,  A61K39/00 ,  A61K2039/5158

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 102, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.