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公开(公告)号：US20240358756A1
公开(公告)日：2024-10-31
申请号：US18599924
申请日：2024-03-08
发明人： Ricarda HANNEN , Jens HUKELMANN , Florian KOEHLER , Daniel Johannes KOWALEWSKI , Heiko SCHUSTER , Oliver SCHOOR , Michael ROEMER , Chih-Chiang TSOU , Jens FRITSCHE
IPC分类号： A61K35/17 , A61K39/00 , A61P35/00 , C07K14/47 , C12N5/0783
CPC分类号： A61K35/17 , A61K39/0011 , A61P35/00 , C07K14/4748 , C12N5/0636
摘要： The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 216, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240299455A1
公开(公告)日：2024-09-12
申请号：US18599860
申请日：2024-03-08
发明人： Ricarda HANNEN , Jens HUKELMANN , Florian KOEHLER , Daniel Johannes KOWALEWSKI , Heiko SCHUSTER , Oliver SCHOOR , Michael ROEMER , Chih-Chiang TSOU , Jens FRITSCHE
IPC分类号： A61K35/17 , A61K39/00 , A61P35/00 , C07K14/47 , C12N5/0783
CPC分类号： A61K35/17 , A61K39/0011 , A61P35/00 , C07K14/4748 , C12N5/0636
摘要： The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 216, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240269184A1
公开(公告)日：2024-08-15
申请号：US18606764
申请日：2024-03-15
发明人： Ricarda HANNEN , Jens HUKELMANN , Florian KOEHLER , Daniel Johannes KOWALEWSKI , Heiko SCHUSTER , Oliver SCHOOR , Michael ROEMER , Chih-Chiang TSOU , Jens FRITSCHE
IPC分类号： A61K35/17 , A61K39/00 , A61P35/00 , C07K14/47 , C12N5/0783
CPC分类号： A61K35/17 , A61K39/0011 , A61P35/00 , C07K14/4748 , C12N5/0636
摘要： The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 216, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240166717A1
公开(公告)日：2024-05-23
申请号：US18433940
申请日：2024-02-06
发明人： Jens HUKELMANN , Heiko SCHUSTER , Lena WULLKOPF , Christoph SCHRAEDER , Jens FRITSCHE , Daniel Johannes KOWALEWSKI , Michael ROEMER , Oliver SCHOOR
IPC分类号： C07K14/725 , A61K35/17 , C07K14/74 , C07K16/28
CPC分类号： C07K14/7051 , A61K35/17 , C07K14/70539 , C07K16/2833 , A61K38/00
摘要： The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240166713A1
公开(公告)日：2024-05-23
申请号：US18433894
申请日：2024-02-06
发明人： Jens HUKELMANN , Heiko SCHUSTER , Lena WULLKOPF , Christoph SCHRAEDER , Jens FRITSCHE , Daniel Johannes KOWALEWSKI , Michael ROEMER , Oliver SCHOOR
IPC分类号： C07K14/725 , A61K35/17 , A61K38/00 , C07K14/74 , C07K16/28
CPC分类号： C07K14/7051 , A61K35/17 , C07K14/70539 , C07K16/2833 , A61K38/00 , C07K2319/30
摘要： The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240158460A1
公开(公告)日：2024-05-16
申请号：US18421968
申请日：2024-01-24
发明人： Jens HUKELMANN , Heiko SCHUSTER , Lena WULLKOPF , Christoph SCHRAEDER , Jens FRITSCHE , Daniel Johannes KOWALEWSKI , Michael ROEMER , Oliver SCHOOR
IPC分类号： C07K14/725 , A61K35/17 , C07K14/74 , C07K16/28
CPC分类号： C07K14/7051 , A61K35/17 , C07K14/70539 , C07K16/2833 , A61K38/00 , C07K2319/30
摘要： The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240067697A1
公开(公告)日：2024-02-29
申请号：US18489600
申请日：2023-10-18
发明人： Jens HUKELMANN , Heiko SCHUSTER , Lena WULLKOPF , Christoph SCHRAEDER , Jens FRITSCHE , Daniel Johannes KOWALEWSKI , Michael ROEMER , Oliver SCHOOR
IPC分类号： C07K14/725 , A61K35/17 , C07K14/74 , C07K16/28
CPC分类号： C07K14/7051 , A61K35/17 , C07K14/70539 , C07K16/2833 , A61K38/00
摘要： The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO:1 to SEQ ID NO:113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240016913A1
公开(公告)日：2024-01-18
申请号：US18458233
申请日：2023-08-30
发明人： Jens HUKELMANN , Heiko SCHUSTER , Ricarda HANNEN , Christoph SCHRAEDER , Jens FRITSCHE , Franziska HOFFGAARD , Daniel Johannes KOWALEWSKI , Oliver SCHOOR
IPC分类号： A61K39/00 , A61P35/00 , C07K14/705 , C07K14/74
CPC分类号： A61K39/0011 , A61P35/00 , C07K14/705 , C07K14/70539 , A61K39/00 , A61K2039/5158
摘要： The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 102, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240016910A1
公开(公告)日：2024-01-18
申请号：US18455683
申请日：2023-08-25
发明人： Jens HUKELMANN , Heiko SCHUSTER , Ricarda HANNEN , Christoph SCHRAEDER , Jens FRITSCHE , Franziska HOFFGAARD , Daniel Johannes KOWALEWSKI , Oliver SCHOOR
IPC分类号： A61K39/00 , A61P35/00 , C07K14/705 , C07K14/74
CPC分类号： A61K39/0011 , A61P35/00 , C07K14/705 , C07K14/70539 , A61K39/00 , A61K2039/5158
摘要： The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 102, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20230190808A1
公开(公告)日：2023-06-22
申请号：US17938577
申请日：2022-10-06
发明人： Jens HUKELMANN , Heiko SCHUSTER , Jens FRITSCHE , Oliver SCHOOR , Frank SCHWOEBEL , Lena Katharina FREUDENMANN
IPC分类号： A61K35/17 , C07K14/725 , C12N5/0783 , C12N5/10
CPC分类号： A61K35/17 , C07K14/7051 , C12N5/0638 , C12N5/10
摘要： A method of treating a metastatic lesion that presents a peptide containing SLLQHLIGL (SEQ ID NO: 310) on a cell surface, including selecting a patient having a metastatic lesion and administering to the patient a composition containing recombinant T lymphocytes or activated T lymphocytes that express a T cell receptor, or a functional fragment thereof, that is reactive with, or binds to, an MHC ligand containing SLLQHLIGL (SEQ ID NO: 310).
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