公开(公告)号：US20110245890A1

公开(公告)日：2011-10-06

申请号：US13071680

申请日：2011-03-25

申请人： Amy Jean Brisben ,  Shibaji Shome ,  Kenneth N. Hayes ,  Yanting Dong ,  Aaron R. McCabe ,  Scott A. Meyer ,  Kevin John Stalsberg

发明人： Amy Jean Brisben ,  Shibaji Shome ,  Kenneth N. Hayes ,  Yanting Dong ,  Aaron R. McCabe ,  Scott A. Meyer ,  Kevin John Stalsberg

IPC分类号： A61N1/08 ,  A61N1/362

CPC分类号： A61N1/36585 ,  A61N1/3712

摘要： An apparatus comprises a cardiac signal sensing circuit, a pacing therapy circuit, and a controller circuit. The controller circuit includes a safety margin calculation circuit. The controller circuit initiates delivery of pacing stimulation energy to the heart using a first energy level, changes the energy level by at least one of: a) increasing the energy from the first energy level until detecting that the pacing stimulation energy induces stable capture, or b) reducing the energy from the first energy level until detecting that the stimulation energy fails to induce capture, and continues changing the stimulation energy level until confirming stable capture or the failure of capture. The safety margin calculation circuit calculates a safety margin of pacing stimulation energy using at least one of a determined stability of a parameter associated with evoked response and a determined range of energy levels corresponding to stable capture or intermittent failure of capture.

摘要翻译： 一种装置包括心脏信号感测电路，起搏治疗电路和控制器电路。 控制器电路包括安全裕度计算电路。 控制器电路使用第一能级开始向心脏传送起搏刺激能量，通过以下至少一种来改变能量水平：a）从第一能量级增加能量直到检测到起搏刺激能量引起稳定的捕获，或 b）减少来自第一能级的能量，直到检测到刺激能量不能诱导捕获，并且继续改变刺激能量水平，直到确认捕获稳定或捕获失败为止。 安全裕度计算电路使用与诱发反应相关联的参数的确定的稳定性以及与捕获的稳定捕获或间歇性故障相对应的能量水平的确定范围中的至少一个来计算起搏刺激能量的安全裕度。

公开(公告)号：US20110098768A1

公开(公告)日：2011-04-28

申请号：US12892378

申请日：2010-09-28

申请人： Shantha Arcot-Krishnamurthy ,  Shibaji Shome ,  Yanting Dong

发明人： Shantha Arcot-Krishnamurthy ,  Shibaji Shome ,  Yanting Dong

IPC分类号： A61N1/365

CPC分类号： A61N1/371 ,  A61N1/3627 ,  A61N1/3684

摘要： A method and device to detect and compare changes in atrial rate and morphology can be used to identify left atrial sense and capture, such as from a quadripolar or other lead located in or around the coronary sinus.

摘要翻译： 用于检测和比较心房率和形态变化的方法和装置可用于鉴定左心房感和捕获，例如来自位于冠状窦内或周围的四极或其他导联。

公开(公告)号：US20100262207A1

公开(公告)日：2010-10-14

申请号：US12822480

申请日：2010-06-24

申请人： Kevin John Stalsberg ,  Yanting Dong ,  Scott A. Meyer ,  John Michael Voegele ,  Derek Daniel Bohn ,  Eric Keith Enrooth ,  Clayton Scott Foster ,  David William Yost

发明人： Kevin John Stalsberg ,  Yanting Dong ,  Scott A. Meyer ,  John Michael Voegele ,  Derek Daniel Bohn ,  Eric Keith Enrooth ,  Clayton Scott Foster ,  David William Yost

IPC分类号： A61N1/08

CPC分类号： A61N1/371 ,  A61B5/0452 ,  A61B5/7203 ,  A61B5/7217 ,  A61B5/7264

摘要： Methods and systems for detecting noise in cardiac pacing response classification processes involve determining that a cardiac response classification is possibly erroneous if unexpected signal content is detected. The unexpected signal content may comprise signal peaks that have polarity opposite to the polarity of peaks used to determine the cardiac response to pacing. Fusion/noise management processes include pacing at a relatively high energy level until capture is detected after a fusion, indeterminate, or possibly erroneous pacing response classification is made. The relatively high energy pacing pulses may be delivered until capture is detected or until a predetermined number of paces are delivered.

摘要翻译： 用于检测心脏起搏反应分类过程中的噪声的方法和系统涉及如果检测到意外的信号内容，则确定心脏反应分类可能是错误的。 意想不到的信号内容可以包括具有与用于确定对起搏的心脏反应的峰的极性相反的极性的信号峰。 融合/噪声管理过程包括在相对高的能量级别进行起搏，直到在融合之后检测到捕获，不确定或可能错误的起搏响应分类。 可以递送相对高的能量起搏脉冲，直到检测到捕获或直到传送预定数量的步数。

公开(公告)号：US20100262204A1

公开(公告)日：2010-10-14

申请号：US12724729

申请日：2010-03-16

申请人： Aaron R. McCabe ,  Shibaji Shome ,  Yanting Dong ,  Amy Jean Brisben

发明人： Aaron R. McCabe ,  Shibaji Shome ,  Yanting Dong ,  Amy Jean Brisben

IPC分类号： A61N1/368

CPC分类号： A61N1/3627 ,  A61N1/3712

摘要： Cardiac resynchronization therapy is delivered to a heart using an extended bipolar electrode configuration in accordance with programmed pacing parameters including a non-zero intraventricular delay. The extended bipolar electrode configuration comprises a left ventricular electrode defining a cathode of the extended bipolar electrode configuration and a right ventricular electrode defining an anode of the extended bipolar electrode configuration. A pace pulse is delivered to the left ventricular electrode and anodal stimulation of the right ventricle is detected based on the sensed response to the pace pulse.

摘要翻译： 使用扩展双极电极配置将心脏再同步治疗按照已编程的起搏参数（包括非零心室延迟）递送至心脏。 扩展双极电极配置包括限定扩展双极电极配置的阴极的左心室电极和限定延伸双极电极配置的阳极的右心室电极。 步速脉冲输送到左心室电极，并且基于感测到的对步速脉冲的响应来检测右心室的阳极刺激。

公开(公告)号：US07711424B2

公开(公告)日：2010-05-04

申请号：US12070004

申请日：2008-02-14

申请人： Scott A. Meyer ,  Yanting Dong ,  Kevin John Stalsberg

发明人： Scott A. Meyer ,  Yanting Dong ,  Kevin John Stalsberg

IPC分类号： A61N1/362 ,  A61N1/365

CPC分类号： A61B5/0452 ,  A61B5/7264 ,  A61N1/362 ,  A61N1/371

摘要： Cardiac devices and methods involve the detection of cardiac signals features in adjacent classification intervals. Portions of the cardiac signal features detected in adjacent classification intervals are associated and are used to classify the cardiac response to a pacing pulse. Associating the portions of the cardiac signal features may be based on expected signal morphology.

摘要翻译： 心脏装置和方法涉及在相邻分类间隔中检测心脏信号特征。 在相邻分类间隔中检测到的心脏信号特征的部分相关联并且用于将心脏反应分类到起搏脉冲。 关联心脏信号特征的部分可以基于预期的信号形态。

公开(公告)号：US20090312815A1

公开(公告)日：2009-12-17

申请号：US12545676

申请日：2009-08-21

申请人： Donald L. Hopper ,  Yinghong Yu ,  Yanting Dong

发明人： Donald L. Hopper ,  Yinghong Yu ,  Yanting Dong

IPC分类号： A61N1/368 ,  A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/36542

摘要： Adaptive rate pacing for improving heart rate kinetics in heart failure patients involves determining onset and sustaining of patient activity. The patient's heart rate response to the sustained activity is evaluated during a time window defined between onset of the activity and a steady-state exercise level. If the patient's heart rate response to the sustained activity is determined to be slow, a pacing therapy is delivered at a rate greater than the patient's intrinsic heart rate based on a profile of the patient's heart rate response to varying workloads. If determined not to be slow, the pacing therapy is withheld. Monitoring-only configurations provide for acquisition and organization of physiological data for heart failure patients. These data can be acquired on a per-patient basis and used to assess the HF status of the patient.

摘要翻译： 用于改善心力衰竭患者心率动力学的适应性起搏速率包括确定患者活动的发病和持续时间。 在活动开始和稳态运动水平之间定义的时间窗口期间评估患者对持续活动的心率反应。 如果患者对持续活动的心率反应被确定为缓慢，则基于患者对不同工作负荷的心率反应的简档，起搏治疗以大于患者内在心率的速率递送。 如果确定不要慢，起搏疗法就被扣留。 仅监测配置提供心脏病患者生理数据的采集和组织。 这些数据可以在每个患者的基础上获得，并用于评估患者的HF状态。

公开(公告)号：US20090163973A1

公开(公告)日：2009-06-25

申请号：US12396267

申请日：2009-03-02

申请人： Scott A. Meyer ,  Yanting Dong

发明人： Scott A. Meyer ,  Yanting Dong

IPC分类号： A61N1/362

CPC分类号： A61B5/04525 ,  A61N1/371

摘要： Cardiac devices and methods using cardiac waveform clustering for template generation are described. A method of characterizing a cardiac response involves delivering pacing pulses to heart, the pulses having an energy greater than a capture threshold. Cardiac signals are sensed following the pulses. Cardiac signal characteristics, waveforms, and/or features are clustered into a plurality of clusters. A cardiac response template is formed using one or more of the plurality of clusters.

摘要翻译： 描述了使用心脏波形聚类用于模板生成的心脏装置和方法。 表征心脏反应的方法包括将起搏脉冲输送到心脏，脉冲具有大于捕获阈值的能量。 在脉冲之后感测到心脏信号。 心脏信号特征，波形和/或特征被聚集成多个聚类。 使用所述多个簇中的一个或多个来形成心脏反应模板。

公开(公告)号：US07529578B2

公开(公告)日：2009-05-05

申请号：US11180937

申请日：2005-07-12

申请人： Yanting Dong ,  Scott A. Meyer ,  Qingsheng Zhu

发明人： Yanting Dong ,  Scott A. Meyer ,  Qingsheng Zhu

IPC分类号： A61B5/04

CPC分类号： A61N1/371 ,  A61B5/04525 ,  A61B5/7217 ,  A61B5/7264

摘要： Methods and systems involve classifying the cardiac response to pacing using a multi-channel approach. Multiple cardiac response signals are sensed via multiple sense channels. Each sense channel comprises a distinct combination of electrodes and sensing circuitry. The cardiac response to the pacing pulse is classified based on the morphology of the cardiac response signals. Classifying the cardiac response involves discriminating between capture, fusion, non-capture, and non-capture with intrinsic activity.

摘要翻译： 方法和系统包括使用多通道方法对心脏起搏应答进行分类。 通过多个感测通道感测多个心脏反应信号。 每个感测通道包括电极和感测电路的不同组合。 基于心脏反应信号的形态对起搏脉搏的心脏反应进行分类。 分类心脏反应包括区分捕获，融合，非捕获和非捕获与内在活动。

公开(公告)号：US07392088B2

公开(公告)日：2008-06-24

申请号：US11116563

申请日：2005-04-28

申请人： Yanting Dong ,  Scott A. Meyer ,  Kevin John Stalsberg

发明人： Yanting Dong ,  Scott A. Meyer ,  Kevin John Stalsberg

IPC分类号： A61N1/368

CPC分类号： A61N1/3712 ,  A61N1/3684

摘要： Multi-chamber pacing may result in capture of one chamber, capture of multiple chambers, fusion, or non-capture. Approaches for detecting various capture conditions during multi-chamber pacing are described. Pacing pulses are delivered to left and right heart chambers during a cardiac cycle. A cardiac electrogram signal is sensed following the delivery of the pacing pulses. Left chamber capture only, right chamber capture only, and bi-chamber capture may be distinguished based on characteristics of the cardiac electrogram signal. Multi-chamber capture detection may be implemented using detection windows having dimensions of time and amplitude. The detection windows are associated with expected features, such as expected signal peaks, under a particular capture condition. The cardiac electrogram signal features are compared to detection windows to determine the capture condition.

摘要翻译： 多腔起搏可能导致一个腔室的捕获，多个腔室的捕获，融合或非捕获。 描述了在多室起搏期间检测各种捕获条件的方法。 在心动周期期间，起搏脉冲被传送到左心室和右心室。 在起搏脉冲输送之后感测心电图信号。 仅左室捕获，右室捕获，双室捕获可以基于心电图信号的特征来区分。 可以使用具有时间和幅度尺寸的检测窗来实现多室捕获检测。 检测窗口与特定捕获条件下的预期特征（例如期望的信号峰值）相关联。 将心电图信号特征与检测窗口进行比较以确定捕获条件。

公开(公告)号：US20070180047A1

公开(公告)日：2007-08-02

申请号：US11301214

申请日：2005-12-12

申请人： Yanting Dong ,  Todd Carpenter ,  Quan Ni ,  Kenneth Hoyme

发明人： Yanting Dong ,  Todd Carpenter ,  Quan Ni ,  Kenneth Hoyme

IPC分类号： G06F15/16 ,  G06F19/00 ,  A61B5/00

CPC分类号： G06F19/3418 ,  A61B5/0002 ,  A61B5/117 ,  A61B5/1171 ,  G06Q50/24

摘要： A system and method for providing authentication of remotely collected external sensor measures is presented. Physiological measures are collected from a source situated remotely from a repository for accumulating such collected physiological measures. An identification of the source from which the physiological measures were collected is determined against authentication data that uniquely identifies a specific patient. The physiological measures are forwarded to the repository upon authenticating the patient identification as originating from the specific patient.

摘要翻译： 提出了一种用于提供远程收集的外部传感器测量的认证的系统和方法。 从远离储存库的源收集生理措施，以积累这种收集的生理措施。 根据唯一识别特定患者的身份验证数据确定收集生理指标的来源的标识。 在将患者身份认证来源于特定患者后，将生理学措施转发到储存库。