公开(公告)号：US07599741B2

公开(公告)日：2009-10-06

申请号：US11478015

申请日：2006-06-29

申请人： Donald L. Hopper ,  Yinghong Yu ,  Yanting Dong

发明人： Donald L. Hopper ,  Yinghong Yu ,  Yanting Dong

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/36542

摘要： Adaptive rate pacing for improving heart rate kinetics in heart failure patients involves determining onset and sustaining of patient activity. The patient's heart rate response to the sustained activity is evaluated during a time window defined between onset of the activity and a steady-state exercise level. If the patient's heart rate response to the sustained activity is determined to be slow, a pacing therapy is delivered at a rate greater than the patient's intrinsic heart rate based on a profile of the patient's heart rate response to varying workloads. If determined not to be slow, the pacing therapy is withheld. Monitoring-only configurations provide for acquisition and organization of physiological data for heart failure patients. These data can be acquired on a per-patient basis and used to assess the HF status of the patient.

摘要翻译： 用于改善心力衰竭患者心率动力学的适应性起搏速率包括确定患者活动的发病和持续时间。 在活动开始和稳态运动水平之间定义的时间窗口期间评估患者对持续活动的心率反应。 如果患者对持续活动的心率反应被确定为缓慢，则基于患者对不同工作负荷的心率反应的简档，起搏治疗以大于患者内在心率的速率递送。 如果确定不要慢，起搏疗法就被扣留。 仅监测配置提供心脏病患者生理数据的采集和组织。 这些数据可以在每个患者的基础上获得，并用于评估患者的HF状态。

公开(公告)号：US20080004664A1

公开(公告)日：2008-01-03

申请号：US11478015

申请日：2006-06-29

申请人： Donald L. Hopper ,  Yinghong Yu ,  Yanting Dong

发明人： Donald L. Hopper ,  Yinghong Yu ,  Yanting Dong

IPC分类号： A61N1/00

CPC分类号： A61N1/3627 ,  A61N1/36542

摘要： Adaptive rate pacing for improving heart rate kinetics in heart failure patients involves determining onset and sustaining of patient activity. The patient's heart rate response to the sustained activity is evaluated during a time window defined between onset of the activity and a steady-state exercise level. If the patient's heart rate response to the sustained activity is determined to be slow, a pacing therapy is delivered at a rate greater than the patient's intrinsic heart rate based on a profile of the patient's heart rate response to varying workloads. If determined not to be slow, the pacing therapy is withheld. Monitoring-only configurations provide for acquisition and organization of physiological data for heart failure patients. These data can be acquired on a per-patient basis and used to assess the HF status of the patient.

摘要翻译： 用于改善心力衰竭患者心率动力学的适应性起搏速率包括确定患者活动的发病和持续时间。 在活动开始和稳态运动水平之间定义的时间窗口期间评估患者对持续活动的心率反应。 如果患者对持续活动的心率反应被确定为缓慢，则基于患者对不同工作负荷的心率反应的简档，起搏治疗以大于患者内在心率的速率递送。 如果确定不要慢，起搏疗法就被扣留。 仅监测配置提供心脏病患者生理数据的采集和组织。 这些数据可以在每个患者的基础上获得，并用于评估患者的HF状态。

公开(公告)号：US20090312815A1

公开(公告)日：2009-12-17

申请号：US12545676

申请日：2009-08-21

申请人： Donald L. Hopper ,  Yinghong Yu ,  Yanting Dong

发明人： Donald L. Hopper ,  Yinghong Yu ,  Yanting Dong

IPC分类号： A61N1/368 ,  A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/36542

摘要： Adaptive rate pacing for improving heart rate kinetics in heart failure patients involves determining onset and sustaining of patient activity. The patient's heart rate response to the sustained activity is evaluated during a time window defined between onset of the activity and a steady-state exercise level. If the patient's heart rate response to the sustained activity is determined to be slow, a pacing therapy is delivered at a rate greater than the patient's intrinsic heart rate based on a profile of the patient's heart rate response to varying workloads. If determined not to be slow, the pacing therapy is withheld. Monitoring-only configurations provide for acquisition and organization of physiological data for heart failure patients. These data can be acquired on a per-patient basis and used to assess the HF status of the patient.

摘要翻译： 用于改善心力衰竭患者心率动力学的适应性起搏速率包括确定患者活动的发病和持续时间。 在活动开始和稳态运动水平之间定义的时间窗口期间评估患者对持续活动的心率反应。 如果患者对持续活动的心率反应被确定为缓慢，则基于患者对不同工作负荷的心率反应的简档，起搏治疗以大于患者内在心率的速率递送。 如果确定不要慢，起搏疗法就被扣留。 仅监测配置提供心脏病患者生理数据的采集和组织。 这些数据可以在每个患者的基础上获得，并用于评估患者的HF状态。

公开(公告)号：US08725255B2

公开(公告)日：2014-05-13

申请号：US11601216

申请日：2006-11-17

申请人： Shantha Arcot-Krishnamurthy ,  Yi Zhang ,  Jiang Ding ,  Yinghong Yu ,  Yanting Dong

发明人： Shantha Arcot-Krishnamurthy ,  Yi Zhang ,  Jiang Ding ,  Yinghong Yu ,  Yanting Dong

IPC分类号： A61N1/365 ,  A61N1/362

CPC分类号： A61N1/3627 ,  A61B5/04011 ,  A61B5/0452 ,  A61N1/365 ,  A61N1/36535 ,  A61N1/36542

摘要： Systems and methods provide for pacing a heart to improve pumping efficiency of the heart, such as by producing a cardiac fusion response for patient's subject to cardiac resynchronization therapy. A pacing parameter, such as an A-V delay, V-V delay, lead/electrode configuration or vector, is adjusted and a cardiac signal vector representative of all or a portion of one or more cardiac activation sequences is monitored during pacing parameter adjustment. A change in a characteristic of the cardiac signal vector is detected in response to an adjusted pacing parameter, the change indicative of a cardiac fusion response. A pacing therapy may be delivered to produce the cardiac fusion response using the adjusted pacing parameter.

摘要翻译： 系统和方法提供心脏起搏以改善心脏的泵送效率，例如通过为患者进行心脏再同步治疗产生心脏融合反应。 调整起搏参数，例如A-V延迟，V-V延迟，引线/电极配置或载体，并且在起搏参数调整期间监测表示一个或多个心脏激活序列的全部或一部分的心脏信号载体。 响应于调整的起搏参数，指示心脏融合反应的变化来检测心脏信号载体的特性变化。 可以使用调整的起搏参数来递送起搏治疗以产生心脏融合反应。

公开(公告)号：US08311631B2

公开(公告)日：2012-11-13

申请号：US12545676

申请日：2009-08-21

申请人： Donald Hopper ,  Yinghong Yu ,  Yanting Dong

发明人： Donald Hopper ,  Yinghong Yu ,  Yanting Dong

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/36542

摘要： Adaptive rate pacing for improving heart rate kinetics in heart failure patients involves determining onset and sustaining of patient activity. The patient's heart rate response to the sustained activity is evaluated during a time window defined between onset of the activity and a steady-state exercise level. If the patient's heart rate response to the sustained activity is determined to be slow, a pacing therapy is delivered at a rate greater than the patient's intrinsic heart rate based on a profile of the patient's heart rate response to varying workloads. If determined not to be slow, the pacing therapy is withheld. Monitoring-only configurations provide for acquisition and organization of physiological data for heart failure patients. These data can be acquired on a per-patient basis and used to assess the HF status of the patient.

摘要翻译： 用于改善心力衰竭患者心率动力学的适应性起搏速率包括确定患者活动的发病和持续时间。 在活动开始和稳态运动水平之间定义的时间窗口期间评估患者对持续活动的心率反应。 如果患者对持续活动的心率反应被确定为缓慢，则基于患者对不同工作负荷的心率反应的简档，起搏治疗以大于患者内在心率的速率递送。 如果确定不要慢，起搏疗法就被扣留。 仅监测配置提供心脏病患者生理数据的采集和组织。 这些数据可以在每个患者的基础上获得，并用于评估患者的HF状态。

公开(公告)号：US20120226328A1

公开(公告)日：2012-09-06

申请号：US13466431

申请日：2012-05-08

申请人： Yanting Dong ,  Yinghong Yu ,  Jiang Ding ,  Scott A. Meyer ,  Xuan Wei ,  Michael John Stucky

发明人： Yanting Dong ,  Yinghong Yu ,  Jiang Ding ,  Scott A. Meyer ,  Xuan Wei ,  Michael John Stucky

IPC分类号： A61N1/365 ,  A61N1/37

CPC分类号： A61N1/3627 ,  A61N1/36585 ,  A61N1/3684

摘要： Systems and methods involve determination of CRT parameters using a number of CRT optimization processes. Each CRT optimization process attempts to return recommended parameters. The CRT parameters are determined based on the recommended parameters returned by one or more of the CRT optimization processes. The CRT optimization processes may be sequentially implemented and the CRT parameters may be determined based on the recommended parameters returned by a first CRT optimization process to return recommended parameters. The CRT parameters may be determined based on a combination of the recommended parameters returned. The CRT optimization processes implemented may be selected from available CRT optimization processes based on patient conditions.

摘要翻译： 系统和方法涉及使用多个CRT优化过程来确定CRT参数。 每个CRT优化过程都会尝试返回推荐的参数。 CRT参数根据一个或多个CRT优化过程返回的推荐参数来确定。 可以顺序地实施CRT优化过程，并且可以基于由第一CRT优化过程返回的推荐参数来返回推荐参数来确定CRT参数。 可以基于返回的推荐参数的组合来确定CRT参数。 可以根据患者条件从可用的CRT优化过程中选择实现的CRT优化处理。

公开(公告)号：US20060224198A1

公开(公告)日：2006-10-05

申请号：US11097460

申请日：2005-04-01

申请人： Yanting Dong ,  Jiang Ding ,  Douglas Daum ,  Scott Meyer ,  Yinghong Yu

发明人： Yanting Dong ,  Jiang Ding ,  Douglas Daum ,  Scott Meyer ,  Yinghong Yu

IPC分类号： A61N1/362

CPC分类号： A61N1/368 ,  A61N1/3682 ,  A61N1/371

摘要： A method and system are described for determining an optimum atrioventricular delay (AVD) interval and/or ventriculo-ventricular delay (VVD) intervals for delivering ventricular resynchronization pacing in an atrial tracking or atrial sequential pacing mode. Evoked response electrograms recorded at different AVD and VVD intervals are used to determine the extent of paced and intrinsic activation.

摘要翻译： 描述了用于确定用于在心房跟踪或心房顺序起搏模式中递送心室再同步起搏的最佳房室延迟（AVD）间隔和/或心室 - 心室延迟（VVD）间隔的方法和系统。 以不同的AVD和VVD间隔记录的诱发反应电图用于确定起搏和内在激活的程度。

公开(公告)号：US20100023078A1

公开(公告)日：2010-01-28

申请号：US11338935

申请日：2006-01-25

申请人： Yanting Dong ,  Yinghong Yu ,  Jiang Ding ,  Scott A. Meyer ,  Xuan Wei ,  Michael John Stucky

发明人： Yanting Dong ,  Yinghong Yu ,  Jiang Ding ,  Scott A. Meyer ,  Xuan Wei ,  Michael John Stucky

IPC分类号： A61N1/00

CPC分类号： A61N1/3627 ,  A61N1/36585 ,  A61N1/3684

摘要： Systems and methods involve determination of CRT parameters using a number of CRT optimization processes. Each CRT optimization process attempts to return recommended parameters. The CRT parameters are determined based on the recommended parameters returned by one or more of the CRT optimization processes. The CRT optimization processes may be sequentially implemented and the CRT parameters may be determined based on the recommended parameters returned by a first CRT optimization process to return recommended parameters. The CRT parameters may be determined based on a combination of the recommended parameters returned. The CRT optimization processes implemented may be selected from available CRT optimization processes based on patient conditions.

摘要翻译： 系统和方法涉及使用多个CRT优化过程来确定CRT参数。 每个CRT优化过程都会尝试返回推荐的参数。 CRT参数根据一个或多个CRT优化过程返回的推荐参数来确定。 可以顺序地实施CRT优化过程，并且可以基于由第一CRT优化过程返回的推荐参数来返回推荐参数来确定CRT参数。 可以基于返回的推荐参数的组合来确定CRT参数。 可以根据患者条件从可用的CRT优化过程中选择实现的CRT优化处理。

公开(公告)号：US07555340B2

公开(公告)日：2009-06-30

申请号：US11097460

申请日：2005-04-01

申请人： Yanting Dong ,  Jiang Ding ,  Douglas R. Daum ,  Scott A. Meyer ,  Yinghong Yu

发明人： Yanting Dong ,  Jiang Ding ,  Douglas R. Daum ,  Scott A. Meyer ,  Yinghong Yu

IPC分类号： A61N1/365

CPC分类号： A61N1/368 ,  A61N1/3682 ,  A61N1/371

摘要： A method and system for determining an optimum atrioventricular delay (AVD) interval and/or ventriculo-ventricular delay (VVD) intervals for delivering ventricular resynchronization pacing in an atrial tracking or atrial sequential pacing mode. Evoked response electrograms recorded at different AVD and VVD intervals are used to determine the extent of paced and intrinsic activation.

摘要翻译： 一种用于确定用于在心房跟踪或心房顺序起搏模式中递送心室再同步起搏的最佳房室延迟（AVD）间隔和/或心室 - 心室延迟（VVD）间隔的方法和系统。 以不同的AVD和VVD间隔记录的诱发反应电图用于确定起搏和内在激活的程度。

公开(公告)号：US08175703B2

公开(公告)日：2012-05-08

申请号：US11338935

申请日：2006-01-25

申请人： Yanting Dong ,  Yinghong Yu ,  Jiang Ding ,  Scott A. Meyer ,  Xuan Wei ,  Michael John Stucky

发明人： Yanting Dong ,  Yinghong Yu ,  Jiang Ding ,  Scott A. Meyer ,  Xuan Wei ,  Michael John Stucky

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/36585 ,  A61N1/3684

摘要： Systems and methods involve determination of CRT parameters using a number of CRT optimization processes. Each CRT optimization process attempts to return recommended parameters. The CRT parameters are determined based on the recommended parameters returned by one or more of the CRT optimization processes. The CRT optimization processes may be sequentially implemented and the CRT parameters may be determined based on the recommended parameters returned by a first CRT optimization process to return recommended parameters. The CRT parameters may be determined based on a combination of the recommended parameters returned. The CRT optimization processes implemented may be selected from available CRT optimization processes based on patient conditions.

摘要翻译： 系统和方法涉及使用多个CRT优化过程来确定CRT参数。 每个CRT优化过程都会尝试返回推荐的参数。 CRT参数根据一个或多个CRT优化过程返回的推荐参数来确定。 可以顺序地实施CRT优化过程，并且可以基于由第一CRT优化过程返回的推荐参数来返回推荐参数来确定CRT参数。 可以基于返回的推荐参数的组合来确定CRT参数。 可以根据患者条件从可用的CRT优化过程中选择实现的CRT优化处理。