公开(公告)号：US4529730A

公开(公告)日：1985-07-16

申请号：US504113

申请日：1983-06-14

申请人： Roland Schneider ,  Christian Warolin ,  Dennis Bigg

发明人： Roland Schneider ,  Christian Warolin ,  Dennis Bigg

IPC分类号： C07D211/46 ,  C07D405/12 ,  A61K31/445

CPC分类号： C07D405/12 ,  C07D211/46

摘要： A piperidine derivative of the formula: ##STR1## wherein R represents a hydrogen atom, a (C.sub.1-4)alkyl, hydroxy(C.sub.1-4)alkyl, (C.sub.1-4)alkoxycarbonyl or benzyl radical, or a benzyl radical carrying a substituent selected from halogen atoms and (C.sub.1-4)alkoxy radicals, or the phenethyl or 3-phenylpropyl radical, and X represents one or more hydrogen or halogen atoms or (C.sub.1-4)alkyl, (C.sub.1-4)alkoxy, trifluoromethyl or methylenedioxy radicals, or alternatively X forms with the phenyl nucleus a naphthyl radical, with the proviso that when R represents a hydrogen atom X is other than a hydrogen atom, are new compounds useful in therapy and, more particularly, as antidepressants.

摘要翻译： 下式的哌啶衍生物：其中R表示氢原子，（C 1-4）烷基，羟基（C 1-4）烷基，（C 1-4）烷氧基羰基或苄基，或苄基 携带选自卤素原子和（C 1-4）烷氧基，或苯乙基或3-苯基丙基的取代基，X表示一个或多个氢或卤素原子或（C 1-4）烷基，（C 1-4）烷氧基， 三氟甲基或亚甲二氧基，或者与苯基一起形成萘基，X条件是当R表示氢原子X不是氢原子时，是用于治疗的新化合物，更具体地说，作为抗抑郁药。

公开(公告)号：US4349557A

公开(公告)日：1982-09-14

申请号：US251744

申请日：1981-04-07

申请人： Dennis Bigg

发明人： Dennis Bigg

IPC分类号： A61K31/425 ,  A61P25/24 ,  A61P25/26 ,  C07D513/04 ,  C07D277/60

CPC分类号： C07D513/04

摘要： Thiazole derivatives of the general formula: ##STR1## wherein n represents 1 or 2 and each of X and Y independently of one another represents one or more substituents selected from hydrogen and halogen atoms, the trifluoromethyl radical and straight- or branched-chain alkyl and alkoxy radicals of 1 to 4 carbon atoms, are new therapeutically useful compounds, especially of interest in the treatment of depression.

摘要翻译： 噻唑衍生物，其通式如下：其中n表示1或2，X和Y各自独立地表示一个或多个选自氢和卤素原子的取代基，三氟甲基和直链或支链烷基和 具有1至4个碳原子的烷氧基是新的治疗有用的化合物，特别是治疗抑郁症感兴趣的化合物。