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公开(公告)号：US20220097140A1
公开(公告)日：2022-03-31
申请号：US17426220
申请日：2020-01-28
申请人： AddUp , Centre National De La Recherche Scientifique (CNRS) , Ecole Normale Superieure Paris-Saclay
摘要： A process for the selective additive manufacture of a three-dimensional object from a layer of powder comprises: applying a layer of additive manufacturing powder to a support or to a previously consolidated layer, emitting a laser beam onto a first point of the layer of additive manufacturing powder so as to consolidate a first zone of the layer of powder comprising the first point, adjusting a power of the laser beam depending on an estimated temperature variation of the layer of powder at a second point, separate from the first point, and emitting a laser beam onto the second point with the adjusted power so as to consolidate a second zone of the layer of powder comprising the second point, the emission of the laser beam onto the first point and onto the second point being temporally separated by the predetermined time interval.
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102.发明申请公开(公告)号：US20220096426A1
公开(公告)日：2022-03-31
申请号：US17547501
申请日：2021-12-10
申请人： Institut National de Ia Sante et de Ia Recherche Medicale (INSERM) , Centre National de la Recherche Scientifique (CNRS) , Sorbonne Universite , Universite de Poitiers , Centre Hospitalier Universitaire de Poitiers
IPC分类号： A61K31/352 , A61P27/02 , A61P25/00 , A61K45/06 , C07D311/20 , C07D311/54
摘要： The present invention relates to a compound of the following general formula (I): or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug, particularly intended for inhibiting a programmed cell death route selected from the group consisting of ferroptosis, oxytosis and cellular necroptosis. The present invention also relates to a compound of general formula (I) for use as a drug for neuroprotection as well as for preventing and/or treating disorders associated with cellular necroptosis or ferroptosis. The present invention also relates to a pharmaceutical composition comprising a compound of general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.
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103.发明授权公开(公告)号：US11290231B2
公开(公告)日：2022-03-29
申请号：US16633283
申请日：2018-07-12
申请人： GREENERWAVE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS— , ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
IPC分类号： H04L5/00 , H04B17/309 , H01Q3/44 , H04B7/0404 , H04W88/08
摘要： A communication network includes an access point, a control unit in communication with the access point, a wave shaping device in communication with the control unit, and a wireless communication device. The control unit determines parameters of the wave shaping device, the parameters being search parameters if the control unit does not receive a pilot signal, and optimization parameters if the control unit receives a pilot signal.
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公开(公告)号：US11285219B2
公开(公告)日：2022-03-29
申请号：US16745041
申请日：2020-01-16
发明人： Robert H. Zimmer , Gilles Guichard , Juliette Fremaux , Sebastien Goudreau , Claire Venin , Laura Mauran
IPC分类号： A61K47/59 , A61P3/00 , C07K7/02 , C07K14/605 , A61K38/00
摘要： The present description relates to peptidomimetic foldamers, and their synthesis. In particular, the description provides peptide-amino urea hybrid peptidomimetic foldamers comprising an alpha amino acid peptide portion and an oligourea portion.
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公开(公告)号：US11285176B2
公开(公告)日：2022-03-29
申请号：US17507748
申请日：2021-10-21
发明人： Sebastian Amigorena , Eliane Piaggio , Christel Goudot , Luigia Pace , Genevieve Almouzni , Leticia Niborski
IPC分类号： A61K35/17 , A61P35/02 , C07K14/725 , C07K14/705 , A61K45/06
摘要： The present invention relates to an engineered immune cell defective for Suv39h1. Preferably, said engineered immune cell further comprises a genetically engineered antigen receptor that specifically binds a target antigen. The present invention also relates to a method for obtaining a genetically engineered immune cell comprising a step consisting in inhibiting the expression and/or activity of Suv39h1 in the immune cell; and further optionally comprising a step consisting in introducing in the said immune cell a genetically engineered antigen receptor that specifically binds to a target antigen. The invention also encompasses said engineered immune cell for their use in adoptive therapy, notably for the treatment of cancer.
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106.发明授权公开(公告)号：US11263781B2
公开(公告)日：2022-03-01
申请号：US16431237
申请日：2019-06-04
申请人： Centre National de la Recherche Scientifique (CNRS) , Universite Paris Descartes , Ecole Nationale Superieure de Chimie de Paris , Assistance Publique-Hopitaux de Paris , Universite De Versailles-St Quentin En Yvelines , Institut National de la Sante et de la Recherche Medicale (INSERM)
发明人： Kathia Lemdani , Johanne Seguin , Armand Tiede Djiro , Jean-Francois Emile , Camille Kurtz , Nicolas Lomenie
摘要： The invention relates to a process for determining an infiltration profile of biological cells of interest in a biological object of interest from a digital histopathological image of biological tissues, a histological stain having previously been applied to the biological tissues, comprising generating a biological cell detection image, pixels associated with the histological stain on the histopathological image being of a predetermined color on said image, determining a distance map comprising distance iso-curves to the boundary of the biological object, and, from the distance map, calculating a curve representative of the surface density of biological cells of interest as a function of distance to the boundary, by counting, for each boundary distance value, pixels that are both of the predetermined color on the detection image and located between the iso-curve associated with said distance value and the consecutive iso-curve.
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公开(公告)号：US20220054618A1
公开(公告)日：2022-02-24
申请号：US17413228
申请日：2019-12-12
申请人： UNIVERSITE CLAUDE BERNARD LYON 1 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE LAVAL , TRANSGENE , ECOLE NORMALE SUPERIEURE DE LYON
发明人： Manuel ROSA-CALATRAVA , Guy BOIVIN , Julia DUBOIS , Mario Andres PIZZORNO , Olivier TERRIER , Aurélien TRAVERSIER
摘要： The present invention relates to the use of the immortalised cell line ECACC 09070703, deposited on 7 Jul. 2009 at the European Collection of Authenticated Cell Cultures (ECACC, Salisbury, UK) under the number 09070703, for the production of a viral vaccine constituted of an attenuated strain derived from a human metapneumovirus.
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公开(公告)号：US11251886B2
公开(公告)日：2022-02-15
申请号：US15022614
申请日：2014-04-02
发明人： Mathias Fink , Geoffroy Lerosey , Matthieu Dupre , Nadége Kaina
摘要： A wave shaping device which comprises a tunable impedance surface and a controller connected to the surface in order to control its impedance. The shaping device further comprises a transmission module for receiving a pilot signal used to control the impedance of the surface.
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公开(公告)号：US11249187B2
公开(公告)日：2022-02-15
申请号：US16319445
申请日：2017-07-10
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , SORBONNE UNIVERSITE , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE) , UNIVERSITÉ PARIS DIDEROT—PARIS 7
摘要： A method for detecting movements of a plurality of points (P) of a surface (21), comprising a measuring step during which an incident ultrasonic wave is emitted into the air towards the surface and an ultrasonic wave reflected into the air by the surface (21) is detected. During the measuring step, each measuring point is illuminated by the incident ultrasonic wave at a multiplicity of angles of incidence, and the reflected ultrasonic wave is detected by a network of receiving transducers (3) comprising a plurality of ultrasonic receiving transducers (3a). The movements of the surface are determined at a measuring point by determining a delay and/or a phase shift between two beam-forming signals for said measuring point.
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公开(公告)号：US20220031807A1
公开(公告)日：2022-02-03
申请号：US17280550
申请日：2019-09-26
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale , Université d'Aix Marseille , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
摘要： The skin is one of first lines of defense against external threats. Tissue-resident macrophages have pivotal functions in tissue-barrier integrity and homeostasis. Upon skin inflammation, a functional crosstalk between the sensory nervous system and tissue-resident immune cells can regulate cutaneous immune responses. However, depending on the pathological context, sensory neurons display pro- or anti-inflammatory regulatory properties. Here the inventors identify, in a model of ultraviolet (UV)-induced skin N damage, a regulatory role for type C low-threshold mechanoreceptor (C-LTMR) sensory neurons on the dynamic of dermal macrophage replacement by inflammatory monocytes through the neuropeptide TAFA4. Tafa4-KO mice present an unresolved fibrotic dermis after UV irradiation. Increased fibrotic score correlates with the upstream persistency of inflammatory monocytes and their MHC-II+ macrophage progeny. Bone marrow chimera revealed that inflammatory monocyte differentiation towards CD206+ dermal macrophage is increased in Tafa4KO recipient. Finally, intradermal injection of TAFA4 at the site of UV irradiation reduces inflammatory monocytes accumulation and skin inflammation in Tafa4-KO mice. The results provide new insight about tissue-resident macrophages dynamic during the resolution of skin fibrosis and thus renders credible the use of TAFA4 for the treatment of skin inflammation.
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