公开(公告)号：US20250147046A1

公开(公告)日：2025-05-08

申请号：US18832712

申请日：2023-01-25

Applicant: ERVIMMUNE ,  CENTRE LEON BERARD ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Inventor： Stéphane DEPIL ,  Vincent ALCAZER

IPC: G01N33/68 ,  A61K31/7088 ,  A61K35/17 ,  A61K38/16 ,  A61P35/00 ,  C07K14/15 ,  C12N5/0783 ,  G16B30/10

Abstract: Methods for identifying HERV-derived T cell epitopes associated with cancer, and peptides that are or that include epitopes identified by the methods, expression vectors encoding the peptides, cytotoxic T lymphocytes (CTLs) of a subject treated with the peptides or vectors and engineered T cells expressing T-cell receptors recognizing the peptides. Also, the peptides, expression vectors, CTLs or engineered T cells as a vaccine or a medicament, and in particular the use of the peptides, expression vectors, CTLs or engineered T cells for use in preventing or treating cancer in a subject in need thereof.

公开(公告)号：US12291752B2

公开(公告)日：2025-05-06

申请号：US17562111

申请日：2021-12-27

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP) ,  UNIVERSITÉ PARIS CITÉ

Inventor： Jerome Galon ,  Franck Pages ,  Bernard Mlecnik ,  Gabriela Bindea

IPC: C12Q1/6886

Abstract: The present invention relates to a method for predicting the survival time of a patient suffering from a solid cancer comprising i) determining in a tumor sample obtained from the patient the gene expression level of at least 7 genes selected from the group consisting of CCR2, CD3D, CD3E, CD3G, CD8A, CXCL10, CXCL11, GZMA, GZMB, GZMK, GZMM, IL15, IRF1, PRF1, STAT1, CD69, ICOS, CXCR3, STAT4, CCL2, and TBX21, ii) comparing every expression level determined at step i) with their predetermined reference value and iii) providing a good prognosis when all expression levels determined at step i) are higher than their predetermined reference values, or providing a bad prognosis when all expression levels determined at step i) are lower than their predetermined reference values or providing an intermediate prognosis when at least one expression level determined value is higher than its predetermined value. The method is also particularly suitable for predicting the responsiveness of the patient to a treatment.

公开(公告)号：US20250134954A1

公开(公告)日：2025-05-01

申请号：US19016492

申请日：2025-01-10

Applicant: UNIVERSITE TOULOUSE III-PAUL SABATIER ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  ETABLISSEMENT FRANÇAIS DU SANG

Inventor： Jean-Philippe COMBIER ,  Anne PREL ,  Frédéric DESCHASEAUX

IPC: A61K38/17 ,  A61P9/10 ,  A61P11/00 ,  A61P19/08 ,  A61P31/14 ,  A61P35/00 ,  C12Q1/6883

Abstract: Compositions containing micropeptides capable of modulating the accumulation of miRs involved in certain pathologies, and the use of these micropeptides for treating the certain pathologies. Also, methods of identifying these micropeptides modulating the accumulation of miRs involved in pathologies. Further, nuclei acids encoding those micropeptides that modulate the accumulation of miRs involved in pathologies.

公开(公告)号：US12280074B2

公开(公告)日：2025-04-22

申请号：US16087471

申请日：2017-03-23

Applicant: CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU) ,  UNIVERSITE DE LILLE ,  UNIVERSITE DU LITTORAL COTE D'OPALE ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  TAIPEI MEDICAL UNIVERSITY

Inventor： David Devos ,  Thierry Burnouf ,  Jean-christophe Devedjian ,  Ming-Li Chou

IPC: A61K35/19 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28

Abstract: A process for preparing a modified heat-treated platelet pellet lysate, said process comprising the steps of: a) Providing a platelet pellet lysate, b) Heat-treating the platelet pellet lysate at a temperature of 55° C. to 65° C. during 20 to 40 minutes, c) Purifying the heat-treated platelet pellet lysate of step b) so as to obtain a modified heat treated platelet pellet lysate having a total protein content of less than 70% of the total protein content of the platelet pellet lysate of step a).

公开(公告)号：US12276000B2

公开(公告)日：2025-04-15

申请号：US17043100

申请日：2019-03-28

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE BREST ,  UNIVERSITÉ DE BRETAGNE OCCIDENTALE ,  INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT ,  ETABLISSEMENT FRANÇAIS DU SANG (EFS)

Inventor： Geneviève Hery-Arnaud ,  Jérôme Mounier ,  Charles-Antoine Guilloux ,  Patricia Lepage ,  Stanislas Mondot ,  Marlène Keravec

IPC: C12Q1/689 ,  C12Q1/686

Abstract: The present invention relates to methods for predicting the risk of developing pulmonary colonization/infection by P. aeruginosa. The inventors analyzed the respiratory tract microbiota from 65 patients sputum samples and compared microbiota data. The inventors found that patients that will remain uninfected from P. aeruginosa exhibited 3-fold higher abundance of Porphyromonas catoniae compared to the other groups. In particular, the present invention relates to a method for predicting the risk of developing pulmonary colonization/infection by P. aeruginosa in a subject suffering from cystic fibrosis (CF) comprising measuring the abundance of Porphyromonas catoniae in a biological sample obtained from said subject.

公开(公告)号：US12274694B2

公开(公告)日：2025-04-15

申请号：US18296543

申请日：2023-04-06

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITÉ PARIS-SACLAY ,  ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS (APHP) ,  HOPITAL MARIE LANNELONGUE

Inventor： Sylvia Cohen-Kaminsky ,  Marc Humbert ,  Sebastien Dumas ,  Gilles Bru-Mercier ,  Samir Messaoudi ,  Jean-Daniel Brion ,  Mouad Alami ,  Gilles Galvani

IPC: C07D471/08 ,  A61K31/439 ,  A61K31/46 ,  A61K45/06 ,  A61P9/12 ,  C07D451/00 ,  C07D451/02

Abstract: The present invention relates to compounds of formula (I): for use as peripheral NMDA receptor antagonists.

公开(公告)号：US20250099540A1

公开(公告)日：2025-03-27

申请号：US18728699

申请日：2023-02-10

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICAL) ,  UNIVERSITÉ PARIS CITÉ

Inventor： Elisa ROSSI

IPC: A61K38/17 ,  A61P7/02 ,  C07K14/705

Abstract: The present invention relates to a method and compositions comprising soluble Endoglin. for the treatment of thrombotic diseases, and more particularly for the treatment of stroke.

公开(公告)号：US20250084437A1

公开(公告)日：2025-03-13

申请号：US18906538

申请日：2024-10-04

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITE PARIS DESCARTES ,  ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS ,  IMAGINE - INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES

Inventor： Annarita MICCIO ,  Vasco MENEGHINI

IPC: C12N15/86 ,  A61K38/42 ,  C12N5/074 ,  C12N9/22

Abstract: This invention relates to recombinant lentiviral vectors, compositions thereof, the use of the vectors or the compositions thereof, kits of parts comprising said vectors or compositions thereof and a catalytically active Cas9 or Cpf1 protein, methods for modifying the genome of a hematopoietic stem/progenitor cell (HSPC), and the HSPC obtainable by such methods.

公开(公告)号：US20250084420A1

公开(公告)日：2025-03-13

申请号：US18294325

申请日：2022-08-02

Applicant: UNIVERSITE DE MONTPELLIER ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Inventor： Nicolas TRICAUD

IPC: C12N15/113 ,  A61P25/02 ,  C12N15/86

Abstract: RNA interferent (RNAi) molecules that inhibit a PMP22 protein expression and/or activity by targeting exon 5 of a nucleic acid sequence encoding the PMP22 protein, and the prevention and treatment of the Charcot-Marie-Tooth type 1A or 1E diseases in which an adeno-associated virus (AAV) vector including an RNAi molecule is administered.

公开(公告)号：US12241125B2

公开(公告)日：2025-03-04

申请号：US18645961

申请日：2024-04-25

Applicant: PML Screening, LLC ,  Université Paris-Saclay ,  The Assistance Publique—Hôpitaux de Paris (APHP) ,  The Institut National de la Santé et de la Recherche Médicale (INSERM)

Inventor： Eli Hatchwell ,  Peggy S. Eis ,  Edward B. Smith, III ,  Yassine Taoufik

IPC: C12Q1/68 ,  C12Q1/6883

Abstract: This document provides methods and materials related to treating a disease. For example, this document provides methods for treating a subject's disease based on identifying the risk of progressive multifocal leukoencephalopathy PML using a genetic test.