公开(公告)号：US07422558B2

公开(公告)日：2008-09-09

申请号：US10754174

申请日：2004-01-09

申请人： Lilip Lau ,  William Hartigan ,  Anuja Patel

发明人： Lilip Lau ,  William Hartigan ,  Anuja Patel

IPC分类号： A61B19/00

CPC分类号： A61F2/2481 ,  A61B17/00234 ,  A61B2017/00243 ,  A61F2002/2484

摘要： A cardiac harness is configured to fit about a portion of a patient's heart so as to exert a compressive force on the heart during at least a portion of the cardiac cycle. The harness can be constructed of a plurality of individual modules assembled ex vivo or in vivo. The modules can have different physical characteristics, such as having different compliance, and may or may not include spring hinges. Portions of a cardiac harness can be connected to each other using a coupling mechanism such as, for example, a zip coupler.

公开(公告)号：US07276022B2

公开(公告)日：2007-10-02

申请号：US11012833

申请日：2004-12-14

申请人： Lilip Lau ,  Bill Hartigan

发明人： Lilip Lau ,  Bill Hartigan

IPC分类号： A61F13/00

CPC分类号： A61F2/2481 ,  A61F2002/0072 ,  A61F2002/2484 ,  A61M1/1003 ,  A61M1/1008 ,  A61M1/1046 ,  A61M1/1048 ,  A61M1/1056 ,  A61M1/1068 ,  A61M1/1086 ,  A61M1/12 ,  A61M1/122 ,  A61M1/127 ,  A61M2205/0266 ,  A61M2205/33 ,  A61M2205/3303 ,  A61M2205/3523 ,  A61M2205/8206 ,  A61M2205/8243 ,  A61N1/0587 ,  A61N1/3627 ,  Y10T29/49995

摘要： A cardiac harness for treating congestive heart failure is disclosed. The harness applies elastic, compressive reinforcement on the left ventricle to reduce deleterious wall tension and to resist shape change of the ventricle during the mechanical cardiac cycle. Rather than imposing a dimension beyond which the heart cannot expand, the harness provides no hard limit over the range of diastolic expansion of the ventricle. Instead, the harness follows the contour of the heart throughout diastole and continuously exerts gentle resistance to stretch. Also disclosed is a method of delivering the cardiac harness to the heart minimally invasively.

摘要翻译： 公开了用于治疗充血性心力衰竭的心脏线束。 线束在左心室施加弹性，压缩加强，以减少有害的壁张力并抵抗机械心动周期中心室的形状变化。 而不是强加超出心脏不能膨胀的维度，线束对心室的舒张期扩张范围没有限制。 相反，线束在整个舒张期跟随心脏的轮廓，并且连续地施加轻微的拉伸阻力。 还公开了一种将心脏线束以最小程度的侵入性递送到心脏的方法。

公开(公告)号：US07174896B1

公开(公告)日：2007-02-13

申请号：US10338934

申请日：2003-01-07

申请人： Lilip Lau

发明人： Lilip Lau

IPC分类号： A61F2/00 ,  A61B19/00

CPC分类号： A61F2/2481 ,  A61F2250/0031

摘要： A method and apparatus for treating heart failure includes applying a bioabsorbable material around at least a portion of a patient's heart. The bioabsorbable material can be applied in conjunction with a nonbioabsorbable structure such as a cardiac harness or in lieu of such a harness. The harness and/or bioabsorbable material is configured to apply a mild compressive force on the heart.

摘要翻译： 用于治疗心力衰竭的方法和装置包括在患者心脏的至少一部分周围应用生物可吸收材料。 生物可吸收材料可以与诸如心脏线束的非吸收性结构结合使用，或代替这种线束。 线束和/或生物可吸收材料构造成在心脏上施加温和的压缩力。

公开(公告)号：US07097613B2

公开(公告)日：2006-08-29

申请号：US11272566

申请日：2005-11-09

申请人： Lilip Lau ,  Anuja Patel

发明人： Lilip Lau ,  Anuja Patel

IPC分类号： A61F2/00

CPC分类号： A61F2/2481

摘要： A cardiac harness for treating or preventing congestive heart failure is configured to be placed about at least a portion of a patient's heart so as to apply a mild compressive force on the heart. In one embodiment, the cardiac harness is configured so that the variation of load as a function of expansion through a selected range of expansion is represented generally in the form y=ax+b, and the value of “a” does not increase as the percent expansion increases.

摘要翻译： 用于治疗或预防充血性心力衰竭的心脏线束被配置为围绕患者心脏的至少一部分放置，以便对心脏施加温和的压力。 在一个实施例中，心脏线束被配置为使得通过选定的扩张范围作为扩张的函数的负载变化通常以y = ax + b的形式表示，并且“a”的值不随着 扩大百分比。

公开(公告)号：US20060094925A1

公开(公告)日：2006-05-04

申请号：US11272566

申请日：2005-11-09

申请人： Lilip Lau ,  Anuja Patel

发明人： Lilip Lau ,  Anuja Patel

IPC分类号： A61F2/00

CPC分类号： A61F2/2481

摘要： A cardiac harness for treating or preventing congestive heart failure is configured to be placed about at least a portion of a patient's heart so as to apply a mild compressive force on the heart. In one embodiment, the cardiac harness is configured so that the variation of load as a function of expansion through a selected range of expansion is represented generally in the form y=ax+b, and the value of “a” does not increase as the percent expansion increases.

公开(公告)号：US07022063B2

公开(公告)日：2006-04-04

申请号：US10698237

申请日：2003-10-31

申请人： Lilip Lau ,  Anuja Patel

发明人： Lilip Lau ,  Anuja Patel

IPC分类号： A61F13/00

CPC分类号： A61F2/2481

摘要： A cardiac harness for treating or preventing congestive heart failure is configured to be placed about at least a portion of a patient's heart so as to apply a mild compressive force on the heart. In one embodiment, the cardiac harness is configured so that the variation of load as a function of expansion through a selected range of expansion is represented generally in the form y=ax+b, and the value of “a” does not increase as the percent expansion increases.

公开(公告)号：US20060009831A1

公开(公告)日：2006-01-12

申请号：US11193043

申请日：2005-07-29

申请人： Lilip Lau ,  Matthew Fishler

发明人： Lilip Lau ,  Matthew Fishler

IPC分类号： A61N1/05

CPC分类号： A61N1/0587 ,  A61F2/2481 ,  A61F2002/2484 ,  A61N1/3756

摘要： A system for treating the heart includes a cardiac harness associated with a cardiac rhythm management device which does not have a lead system. Multiple pacing and sensing electrodes are attached to the cardiac harness but not to the cardiac rhythm management device. The cardiac harness applies a compressive force on the heart during diastole and systole, and the cardiac rhythm management device will deliver an electrical pulse to the pacing electrodes on the heart for pacing/sensing therapy. The cardiac harness and cardiac rhythm management device are both delivered and implanted by minimally invasive access.

摘要翻译： 用于治疗心脏的系统包括与不具有引导系统的心律管理装置相关联的心脏线束。 多个起搏和感测电极连接到心脏线束，但不连接到心律管理装置。 心脏线束在舒张期和收缩期间对心脏施加压缩力，并且心律管理装置将向心脏上的起搏电极递送电脉冲用于起搏/感测治疗。 心脏线束和心律管理装置通过微创入路进行输送和植入。

公开(公告)号：US20050182290A1

公开(公告)日：2005-08-18

申请号：US11109175

申请日：2005-04-19

申请人： Lilip Lau ,  Joshua Wallin

发明人： Lilip Lau ,  Joshua Wallin

IPC分类号： A61B17/00 ,  A61B17/30 ,  A61F2/00 ,  A61F2/06 ,  A61F13/00

CPC分类号： A61F2/2481 ,  A61B17/00234 ,  A61B2017/00238 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/308 ,  A61B2018/00392 ,  A61F2002/2484

摘要： The apparatus includes and elongate body having a proximal portion and a distal portion. The body includes a cavity sized to contain a cardiac harness in a compacted configuration and also includes a plurality of elongate push rods movable with respect to the body. The cardiac harness is releasably connected to each of the push rods such that advancement of the push rods in a distal direction moves the harness from a compacted configuration, within the cavity, to an expanded configuration, outside the cavity. The apparatus also includes a releasing member for releasing the connections between the push rods and the harness upon actuation of the releasing member by a user.

摘要翻译： 该装置包括具有近端部分和远端部分的细长主体。 身体包括尺寸适于容纳处于紧凑构造的心脏线束的腔体，并且还包括可相对于身体移动的多个细长推杆。 心脏线束可释放地连接到每个推杆，使得推杆在远侧方向的前进将线束从空腔内的压实构型移动到腔外的扩张构型。 该装置还包括释放构件，用于在使用者致动释放构件时释放推杆和线束之间的连接。

公开(公告)号：US06908479B2

公开(公告)日：2005-06-21

申请号：US10427514

申请日：2003-05-01

申请人： Lilip Lau ,  William M. Hartigan ,  John J. Frantzen

发明人： Lilip Lau ,  William M. Hartigan ,  John J. Frantzen

IPC分类号： A61F2/00 ,  A61F2/86 ,  A61F2/88 ,  C23F1/02 ,  C23F1/04 ,  A61F2/06

CPC分类号： A61F2/86 ,  A61F2/848 ,  A61F2/88 ,  A61F2/89 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91533 ,  A61F2002/9155 ,  A61F2002/91558 ,  A61F2002/91575 ,  A61F2210/0019 ,  A61M2025/1081 ,  C23F1/02 ,  C23F1/04 ,  Y10S623/901 ,  Y10S623/903 ,  Y10S623/921 ,  Y10T29/49995

摘要： The invention is directed to an expandable stent for implantation in a body lumen, such as an artery, and a method for making it from a single length of tubing. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common axis and interconnected by one or more interconnective elements. The individual radially expandable cylindrical elements consist of ribbon-like material disposed in an undulating pattern. Portions of the expanded stent project outwardly into engagement with the vessel wall to more securely attach the stent.

公开(公告)号：US20050102016A1

公开(公告)日：2005-05-12

申请号：US11008733

申请日：2004-12-08

申请人： Lilip Lau ,  Bill Hartigan

发明人： Lilip Lau ,  Bill Hartigan

IPC分类号： A61N1/05 ,  A61B17/00 ,  A61F2/00 ,  A61F2/24 ,  A61N1/362 ,  A61N1/375

CPC分类号： A61F2/2481 ,  A61F2002/0072 ,  A61F2002/2484 ,  A61M1/1003 ,  A61M1/1008 ,  A61M1/1046 ,  A61M1/1048 ,  A61M1/1056 ,  A61M1/1068 ,  A61M1/1086 ,  A61M1/12 ,  A61M1/122 ,  A61M1/127 ,  A61M2205/0266 ,  A61M2205/33 ,  A61M2205/3303 ,  A61M2205/3523 ,  A61M2205/8206 ,  A61M2205/8243 ,  A61N1/0587 ,  A61N1/3627 ,  Y10T29/49995

摘要： A cardiac harness for treating congestive heart failure is disclosed. The harness applies elastic, compressive reinforcement on the left ventricle to reduce deleterious wall tension and to resist shape change of the ventricle during the mechanical cardiac cycle. Rather than imposing a dimension beyond which the heart cannot expand, the harness provides no hard limit over the range of diastolic expansion of the ventricle. Instead, the harness follows the contour of the heart throughout diastole and continuously exerts gentle resistance to stretch. Also disclosed is a method of delivering the cardiac harness to the heart minimally invasively.

摘要翻译： 公开了用于治疗充血性心力衰竭的心脏线束。 线束在左心室施加弹性，压缩加强，以减少有害的壁张力并抵抗机械心动周期中心室的形状变化。 而不是强加超出心脏不能膨胀的维度，线束对心室的舒张期扩张范围没有限制。 相反，线束在整个舒张期跟随心脏的轮廓，并且连续地施加轻微的拉伸阻力。 还公开了一种将心脏线束以最小程度的侵入性递送到心脏的方法。