公开(公告)号：US07507836B2

公开(公告)日：2009-03-24

申请号：US10550968

申请日：2004-03-22

申请人： Mark E. Duggan ,  Craig W. Lindsley ,  David D. Wisnoski

发明人： Mark E. Duggan ,  Craig W. Lindsley ,  David D. Wisnoski

IPC分类号： C07D209/48 ,  C07C233/05 ,  A61K31/40 ,  A61K31/165

CPC分类号： C07D417/12 ,  C07D209/48 ,  C07D213/81 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D513/04

摘要： The present invention is directed to compounds which are allosteric modulators of metabotropic glutamate receptors, including the mGluR5 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

摘要翻译： 本发明涉及代谢型谷氨酸受体的变构调节剂（包括mGluR5受体）的化合物，它们可用于治疗或预防与谷氨酸能力障碍相关的神经和精神疾病以及涉及代谢型谷氨酸受体的疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及代谢型谷氨酸受体的疾病中的用途。

公开(公告)号：US07399764B2

公开(公告)日：2008-07-15

申请号：US10530252

申请日：2003-10-24

申请人： Mark E. Duggan ,  Craig W. Lindsley ,  Zhijian Zhao

发明人： Mark E. Duggan ,  Craig W. Lindsley ,  Zhijian Zhao

IPC分类号： A61K31/50 ,  A61K31/497 ,  C07D241/00 ,  C07D487/00

CPC分类号： A61K31/495 ,  A61K45/06 ,  C07D487/04 ,  C07D495/04

摘要： The present invention is directed to compounds which contain a five-membered heterocyclic ring fused to a substituted pyrazine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

摘要翻译： 本发明涉及含有与被抑制Akt（丝氨酸/苏氨酸蛋白激酶）活性的取代吡嗪部分稠合的五元杂环的化合物。 本发明还涉及含有本发明化合物的治疗组合物和治疗癌症的方法，包括施用本发明化合物。

公开(公告)号：US07273869B2

公开(公告)日：2007-09-25

申请号：US10510066

申请日：2003-04-04

申请人： Craig W. Lindsley ,  Zhijian Zhao

发明人： Craig W. Lindsley ,  Zhijian Zhao

IPC分类号： A61K31/498 ,  A61K31/4985 ,  C07D241/42 ,  C07D487/04

CPC分类号： C07D401/14 ,  C07D487/04 ,  C07D519/04

摘要： The present invention is directed to compounds comprising a ring-fused quinoxalinyl moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention

摘要翻译： 本发明涉及包含抑制Akt（丝氨酸/苏氨酸蛋白激酶）活性的环稠合喹喔啉基部分的化合物。 本发明进一步涉及含有本发明化合物的治疗组合物和治疗癌症的方法，包括施用本发明化合物

公开(公告)号：US07223738B2

公开(公告)日：2007-05-29

申请号：US10510069

申请日：2003-04-04

申请人： Mark T. Bilodeau ,  Mark E. Duggan ,  John C. Hartnett ,  Craig W. Lindsley ,  Peter J. Manley ,  Zhicai Wu ,  Zhijian Zhao

发明人： Mark T. Bilodeau ,  Mark E. Duggan ,  John C. Hartnett ,  Craig W. Lindsley ,  Peter J. Manley ,  Zhicai Wu ,  Zhijian Zhao

IPC分类号： A01N43/04 ,  A01N43/58 ,  A01N43/60 ,  A01N43/42 ,  A61K31/70 ,  A61K31/50 ,  A61K31/495 ,  A61K31/52 ,  A61K31/47 ,  C07D487/00 ,  C07D491/00 ,  C07H15/00 ,  C07H17/00 ,  C07H17/02 ,  C09B25/00

CPC分类号： C07D401/10 ,  A61K31/498 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04

摘要： The present invention is directed to compounds comprising a 2,3-diphenylquinoxaline moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.