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101.
公开(公告)号:US4454106A
公开(公告)日:1984-06-12
申请号:US386109
申请日:1982-06-07
Applicant: Otto A. Gansow , Mette Strand
Inventor: Otto A. Gansow , Mette Strand
CPC classification number: C07K16/18 , A61K51/1093 , C07K16/1036 , C07K16/3015 , A61K2121/00 , Y10S436/804 , Y10S436/819
Abstract: Therapeutic and diagnostic methods employing metal chelate conjugated monoclonal antibodies are described. Metals employed in therapeutic conjugated antibodies include alpha particle, beta particle or Auger electron emitting isotopes. Diagnostic methods may be either in vivo or in vitro. Chelated metals employed in diagnostic techniques may include, inter alia, gamma or positron emitting metals as well as fluorogenic or paramagnetic metals.
Abstract translation: 描述了使用金属螯合物缀合的单克隆抗体的治疗和诊断方法。 用于治疗性结合抗体的金属包括α粒子,β粒子或俄歇电子发射同位素。 诊断方法可以是体内或体外。 用于诊断技术的螯合金属尤其可以包括γ或正电子发射金属以及荧光或顺磁金属。