公开(公告)号：US10059758B2

公开(公告)日：2018-08-28

申请号：US15794541

申请日：2017-10-26

Applicant: GENEURO SA

Inventor： Corinne Bernard ,  Alois Bernhardt Lang ,  Herve Perron ,  Jean-Baptiste Bertrand

IPC: A61K39/395 ,  C07K16/10 ,  A61K39/00

CPC classification number: C07K16/1036 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

Abstract: A ligand includes each of the complementary-determining regions (CDRs) set forth in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 SEQ ID No. 4, SEQ ID No. 5 and SEQ ID No. 6 or any sequence having either number of substituted aminoacids within said sequences as indicated in the following, from 0 to 3 in CDR1 (SEQ ID No.1), from 0 to 2 in CDR2 (SEQ ID No.2), from 0 to 2 in CDR3 (SEQ ID No.3), from 0 to 1 in CDR4 (SEQ ID No.4), from 0 to 4 in CDR5 (SEQ ID No.5), from 0 to 2 in CDR6 (SEQ ID No.6), or aminoacids substituted with other aminoacids having equivalent chemical functions and properties, within said sequences SEQ ID No. 1 to SEQ ID No. 6.

公开(公告)号：US20180208663A1

公开(公告)日：2018-07-26

申请号：US15922921

申请日：2018-03-16

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Cheng-I WANG ,  Peter BRAUER ,  Siok Ping YEO ,  Hwee Ching TAN ,  John Edward CONNOLLY

IPC: C07K16/28 ,  A61K47/68

CPC classification number: C07K16/2866 ,  A61K38/1709 ,  A61K39/3955 ,  A61K47/6849 ,  A61K2039/505 ,  A61K2039/57 ,  C07K16/1036 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/565 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00

Abstract: Anti-CD122 and/or γc antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.

公开(公告)号：US20180195137A1

公开(公告)日：2018-07-12

申请号：US15580042

申请日：2016-06-08

Applicant: Swansea University

Inventor： Paul Dyson ,  Miranda Whitten

IPC: C12R1/01 ,  C12N15/113 ,  C07K16/10 ,  A01N63/02 ,  A01N37/46 ,  C12N15/74 ,  A01N25/00

CPC classification number: C12R1/01 ,  A01N25/006 ,  A01N37/46 ,  A01N63/00 ,  A01N63/02 ,  C07K16/1036 ,  C12N15/113 ,  C12N15/746 ,  C12N2310/14

Abstract: The invention relates to a genetically transformed or transfected bacterial cell of a gut symbiont of an insect belonging to the Order Thysanoptera wherein said cell is transformed to express double-stranded RNA (dsRNA) active against at least one selected insect gene; a vector for transforming or transfecting said bacterial cell; an insect including said transformed bacterial cell and a method of pest control employing the use of said bacterial cell and/or said insect.

公开(公告)号：US20170334952A1

公开(公告)日：2017-11-23

申请号：US15495627

申请日：2017-04-24

Applicant: Rutgers, The State University of New Jersey

Inventor： Vincent K. Tsiagbe ,  Yu Li

IPC: C07K14/15 ,  C12Q1/68 ,  C07K16/10 ,  G01N33/574 ,  C12Q1/70 ,  A61K38/00

CPC classification number: C07K14/15 ,  A61K38/00 ,  C07K7/08 ,  C07K14/005 ,  C07K16/1036 ,  C07K16/1063 ,  C07K16/30 ,  C07K2317/34 ,  C07K2317/55 ,  C12N2710/14143 ,  C12N2740/10022 ,  C12N2740/13022 ,  C12Q1/68 ,  C12Q1/702 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57426 ,  G01N2333/15

Abstract: The present invention relates to methods and kits for diagnosis of cancer in a subject by detecting human endogenous retrovirus env (HERV-WL) polypeptides.

公开(公告)号：US20140302040A2

公开(公告)日：2014-10-09

申请号：US13894865

申请日：2013-05-15

Applicant: Daiichi Sankyo Company, Limited

Inventor： Satomichi Yoshimura ,  Tatsuya Kurihara ,  Kayoko Kawashima ,  Masato Hoshino ,  Kumiko Kadoshima ,  Maki Tsujimoto ,  Takako Kimura ,  Jun Hasegawa

IPC: C07K16/10 ,  A61K45/06 ,  A61K39/42 ,  G01N33/68

CPC classification number: C07K16/1036 ,  A61K39/42 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/564 ,  G01N33/6893

Abstract: The present invention provides an antibody that recognizes a polypeptide comprising the amino acid sequence represented by SEQ ID NO: 15 in the Sequence Listing and has an anti-arthritic function, or a functional fragment thereof.

公开(公告)号：US20130040369A1

公开(公告)日：2013-02-14

申请号：US13551286

申请日：2012-07-17

Applicant: Robert H. Silverman ,  Eric A. Klein ,  Graham Casey ,  Joseph DeRisi ,  Don Ganem

Inventor： Robert H. Silverman ,  Eric A. Klein ,  Graham Casey ,  Joseph DeRisi ,  Don Ganem

IPC: C12N7/00 ,  C07K14/15

CPC classification number: C12N7/00 ,  A61K39/00 ,  C07K14/005 ,  C07K16/1036 ,  C12N9/22 ,  C12N2740/13021 ,  C12N2740/13022 ,  C12Q1/6886 ,  C12Q1/70 ,  C12Q1/701 ,  C12Q2600/136

Abstract: The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.

Abstract translation: 本发明提供了编码病毒的分离的核酸序列; 包含病毒的氨基酸序列的分离的多肽; 包含病毒核酸序列的载体; 包含载体的细胞; 对病毒具有结合特异性的抗体及其抗原结合片段; 检测或筛选病毒的方法（例如，在个体中）; 识别抑制病毒的药剂的方法; 诱导对病毒的免疫应答的方法; 治疗与个体（例如癌症如前列腺癌）中XMRV存在相关的疾病的方法; 检测无症状癌症的方法（例如前列腺癌）; 识别患有癌症风险的个体（例如前列腺癌）的方法; 和用于检测病毒的工具包。

公开(公告)号：US08183349B2

公开(公告)日：2012-05-22

申请号：US12828161

申请日：2010-06-30

Applicant: Xiaoxing Qiu ,  John R. Hackett, Jr. ,  Ka-Cheung X. Luk ,  Priscilla Swanson

Inventor： Xiaoxing Qiu ,  John R. Hackett, Jr. ,  Ka-Cheung X. Luk ,  Priscilla Swanson

IPC: C07K16/18

CPC classification number: C07K16/1036 ,  A61K39/00 ,  C07K14/005 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/21 ,  C12N2740/13022

Abstract: The present invention relates generally to assays for the detection of Xenotropic Murine Leukemia Virus-related Retrovirus (“XMRV”) and diseases associated with XMRV infection. Additionally, the invention relates to specific XMRV antigens capable of inducing an immunogenic response as well as XMRV-related nucleic acids having significant diagnostic, screening, and therapeutic utilities.

Abstract translation: 本发明一般涉及用于检测嗜酸性白血病病毒相关逆转录病毒（“XMRV”）和与XMRV感染有关的疾病的检测方法。 此外，本发明涉及能够诱导免疫原性应答的特异性XMRV抗原以及具有显着诊断，筛选和治疗效用的XMRV相关核酸。

公开(公告)号：US08133727B2

公开(公告)日：2012-03-13

申请号：US12622379

申请日：2009-11-19

Applicant: Xin Luo ,  Lili Yang ,  David Baltimore

Inventor： Xin Luo ,  Lili Yang ,  David Baltimore

IPC: C12N5/08 ,  C12N5/00 ,  C12N5/02

CPC classification number: C12N5/0635 ,  C07K16/00 ,  C07K16/1036 ,  C07K16/1045 ,  C12N2501/056 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/22 ,  C12N2501/23 ,  C12N2501/26 ,  C12N2501/52 ,  C12N2502/1394 ,  C12N2510/02

Abstract: The present disclosure relates to systems, methods and compositions for the generation of antibody-producing B cells in vitro. Some embodiments are related to an in vitro system for generating antibody-producing B cells from hematopoietic stem/progenitor cells (HSPCs).

Abstract translation: 本公开涉及用于在体外产生产生抗体的B细胞的系统，方法和组合物。 一些实施方案涉及用于从造血干细胞/祖细胞（HSPC）产生产生抗体的B细胞的体外系统。

公开(公告)号：US20110135674A1

公开(公告)日：2011-06-09

申请号：US12828174

申请日：2010-06-30

Applicant: XIAOXING QIU ,  JAYDIP DAS GUPTA ,  JOHN R. HACKETT, JR. ,  KA-CHEUNG X. LUK ,  ROBERT SILVERMAN ,  PRISCILLA SWANSON

Inventor： XIAOXING QIU ,  JAYDIP DAS GUPTA ,  JOHN R. HACKETT, JR. ,  KA-CHEUNG X. LUK ,  ROBERT SILVERMAN ,  PRISCILLA SWANSON

IPC: A61K39/00 ,  C07K14/00 ,  G01N33/53 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  C12Q1/68 ,  A61K31/7105 ,  A61P35/00 ,  A61P37/04 ,  A61P31/14

CPC classification number: C07K16/1036 ,  A61K39/00 ,  C07K14/005 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/21 ,  C12N2740/13022

Abstract: The present invention relates generally to assays for the detection of Xenotropic Murine Leukemia Virus-related Retrovirus (“XMRV”) and diseases associated with XMRV infection. Additionally, the invention relates to specific XMRV antigens capable of inducing an immunogenic response as well as XMRV-related nucleic acids having significant diagnostic, screening, and therapeutic utilities.

公开(公告)号：US20100074894A1

公开(公告)日：2010-03-25

申请号：US12449327

申请日：2008-02-11

Applicant: Herve Perron

Inventor： Herve Perron

IPC: A61K39/395 ,  A61P31/12 ,  C07K16/08

CPC classification number: C07K16/1036 ,  A61K2039/505

Abstract: A pharmaceutical composition that contains, as an active ingredient, at least one antibody directed against the HERV-W envelope protein, except for any antibody specifically directed against the binding site between said env protein and the hASCT1 or hASCT2 receptor.

Abstract translation: 除了特异性针对所述env蛋白和hASCT1或hASCT2受体之间的结合位点的任何抗体外，其含有针对HERV-W包膜蛋白的至少一种抗体作为活性成分的药物组合物。