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公开(公告)号:US20230381163A1
公开(公告)日:2023-11-30
申请号:US18323382
申请日:2023-05-24
Applicant: The United States Government As Represented By The Department Of Veterans Affairs , MUSC Foundation for Research Development
Inventor: Baerbel Rohrer , Tanjina Akter
IPC: A61K31/4439 , A61K45/06
CPC classification number: A61K31/4439 , A61K45/06
Abstract: The disclosure relates to dabigatran and methods of treating age-related macular degeneration in a subject. The method comprises administering to a patient in need of treatment an effective amount of dabigatran.
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公开(公告)号:US11821971B2
公开(公告)日:2023-11-21
申请号:US17765315
申请日:2021-09-07
Applicant: MUSC Foundation for Research Development
Inventor: Dale H. Mugler , William S. Clary
IPC: G01R33/46 , G01R33/485
CPC classification number: G01R33/4625 , G01R33/485
Abstract: A method comprising collecting magnetic resonance imaging (MRI) scanner data corresponding to a region of interest, establishing a spectral peak profile associated with at least one metabolite in the region of interest, wherein the spectral peak profile comprises a term in the FID vector signal included in the collected MRI scanner data, selecting at least three counter indices and corresponding points on the spectral peak profile to compute a linear fractional transformation (LFT), computing an N-dimensional vector outlining a spectral circle in a complex plane by applying the LFT to each counter index included in a set of equally-spaced counter indices associated with a three-dimensional spectrum representation of the collected MRI scanner data, shifting the spectral circle to eliminate a baseline offset for a magnitude spectrum associated with the complex plane, rotating the shifted spectral circle to produce a rotated spectral circle.
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公开(公告)号:US11813131B2
公开(公告)日:2023-11-14
申请号:US17410363
申请日:2021-08-24
Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
Inventor: Stephen P. Kalhorn , Mark E. Semler
CPC classification number: A61C17/06 , A61B90/70 , A61M1/84 , A61B2090/701 , A61M2209/10
Abstract: A declogging assembly (20) is configured for use with a suction conduit (10). The suction conduit has a head (14) at a first end (15) and a vacuum tube connection (16) at a second end (17). The assembly includes a body (30). The body defines a first aperture (32), a second aperture (34), and a third aperture (36). The assembly also includes a plug (40) disposed within the body (30). The plug has a surface (42) configured to contact the head (14) of the suction conduit (10) so as to move the plug from a first position, in which the first aperture (32) is in fluid communication with the second aperture (34), to a second position, in which the first aperture (32) is in fluid communication with the third aperture (36). The assembly (20) also includes a biasing member (50) configured to bias the plug into the first position.
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公开(公告)号:US11771685B2
公开(公告)日:2023-10-03
申请号:US17264714
申请日:2019-07-29
Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
Inventor: James C. Chou , Sherine S. L. Chan , Richard A. Himes
IPC: A61K31/4406 , A61P25/08 , A61K31/136 , A61K31/18
CPC classification number: A61K31/4406 , A61K31/136 , A61K31/18 , A61P25/08
Abstract: Compounds and methods are provided for the treatment of neurological or mitochondrial diseases, including epilepsy. In some embodiments, the compounds are substituted 1,4-naphthoquinones.
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115.
公开(公告)号:US11464740B2
公开(公告)日:2022-10-11
申请号:US16862540
申请日:2020-04-29
Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College , MUSC FOUNDATION FOR RESEARCH DEVELOPMENT , APPLIED RESEARCH CENTER
Inventor: Paul M. Weinberger , George Wicks , William D. Hill
Abstract: Methods and monodisperse glass microsphere composites comprising a porous wall hollow-glass microsphere; a cargo of a therapeutic is loaded inside of the porous wall hollow-glass microsphere; and a first shell fully encapsulating the porous wall hollow-glass microsphere and capping pores in the walls, retaining the cargo inside of the porous wall hollow-glass microsphere.
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公开(公告)号:US20220125774A1
公开(公告)日:2022-04-28
申请号:US17264714
申请日:2019-07-29
Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
Inventor: James C. CHOU , Sherine S.L. CHAN , Richard A. HIMES
IPC: A61K31/4406 , A61K31/136 , A61K31/18 , A61P25/08
Abstract: Compounds and methods are provided for the treatment of neurological or mitochondrial diseases, including epilepsy. In some embodiments, the compounds are substituted 1,4-naphthoquinones.
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公开(公告)号:US11278424B2
公开(公告)日:2022-03-22
申请号:US16424455
申请日:2019-05-28
Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
Inventor: Mark Evald Semler , Bruce Frankel , Joseph Ruscito , Christopher Hapstack
Abstract: Expandable vertebral body implants, systems, instruments, and methods of assembly and using the implants, systems, and instruments are disclosed. The vertebral body implant includes a body with a first end and a second end, a first rotating member rotatably coupled to the first end, wherein an end includes a plurality of first notches inset into the first rotating member, a second rotating member rotatably coupled to the second end, wherein an end includes a plurality of second notches inset into the second rotating member, a first extension member moveably coupled to the first end, and a second extension member moveably coupled to the second end. The expandable cage system comprises a vertebral body implant and an insertion instrument. Methods for assembling and using the vertebral body implants and instruments are also disclosed.
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公开(公告)号:US20210388080A1
公开(公告)日:2021-12-16
申请号:US17228279
申请日:2021-04-12
Applicant: The Regents of The University of Colorado, A Body Corporate , MUSC Foundation For Research Development , United States Government as Represented by the Department of Veterans Affairs
Inventor: Baerbel M. Rohrer , V. Michael Holers , Stephen Tomlinson , Joshua M. Thurman , Carl Atkinson , Liudmila Kulik
IPC: C07K16/28 , A61K39/395 , A61K45/06
Abstract: The present invention provides targeted delivery methods and constructs for treating inflammatory diseases and/or detecting in vivo tissue injuries in an individual. The targeted delivery approach utilizes an antibody that recognizes an epitope found to be present at sites of inflammation. The invention also provides methods of inhibiting complement-driven inflammation in the eye in an individual, comprising administering to the individual an antibody or a fragment thereor or compositions thereof, wherein the antibody or fragment thereof specifically binds to Annexin IV or phospholipid. Also provided are related methods of treating a complement-associated ocular disease or an ocular disease involving oxidative damage. Additionally, the invention provides methods of detecting complement-mediated injury in an eye tissue of an individual, comprising administering to the individual a construct or compositions thereof, wherein the construct comprises (a) an antibody or fragment thereof that specifically binds to Annexin IV or phospholipid; and (b) a detectable moiety.
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公开(公告)号:US20210379270A1
公开(公告)日:2021-12-09
申请号:US17410363
申请日:2021-08-24
Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
Inventor: Stephen P. Kalhorn , Mark E. Semler
Abstract: A declogging assembly (20) is configured for use with a suction conduit (10). The suction conduit has a head (14) at a first end (15) and a vacuum tube connection (16) at a second end (17). The assembly includes a body (30). The body defines a first aperture (32), a second aperture (34), and a third aperture (36). The assembly also includes a plug (40) disposed within the body (30). The plug has a surface (42) configured to contact the head (14) of the suction conduit (10) so as to move the plug from a first position, in which the first aperture (32) is in fluid communication with the second aperture (34), to a second position, in which the first aperture (32) is in fluid communication with the third aperture (36). The assembly (20) also includes a biasing member (50) configured to bias the plug into the first position.
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120.
公开(公告)号:US20210371534A1
公开(公告)日:2021-12-02
申请号:US17335355
申请日:2021-06-01
Applicant: MUSC Foundation for Research Development , The United States Government as Represented by the Department of Veterans Affairs , Universitat De Barcelona
Inventor: Stephen Tomlinson , Ali Alawieh , Pablo Engel
IPC: C07K16/28 , C07K14/705 , A61P9/10
Abstract: The present invention describes compositions and methods for targeting complement inhibition to sites of p-selectin expression, and compositions for inhibiting p-selectin and complement.
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