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公开(公告)号：US20250154595A1
公开(公告)日：2025-05-15
申请号：US18941569
申请日：2024-11-08
Inventor： Ko Eun CHOI , Joong-Seok KIM
IPC: C12Q1/6883
Abstract: Provided are a submandibular gland tissue biomarker for diagnosis, prognosis prediction, or treatment of Parkinson's disease (PD), a method for diagnosing or predicting the prognosis of PD using the same, and a method for screening substances for treating PD, where it has been confirmed that an SNCAIP gene is significantly decreased and the level of 15 types of miRNA is increased in tissues collected from submandibular gland tissues, and thus PD may be diagnosed using the marker, particularly for subject groups in which the presence or absence of PD cannot be determined by α-synuclein, and since the marker reflects the correlation between genes and environmental factors identified in subjects with PD, the marker can be used as a diagnostic and prognostic biomarker, as well as a new therapeutic target for pathological mechanism of PD.
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公开(公告)号：US20250134711A1
公开(公告)日：2025-05-01
申请号：US18927099
申请日：2024-10-25
Inventor： Dong Hyun JEE
IPC: A61F9/007
Abstract: An embodiment relates to a safety vitreous body cutting device capable of safely removing only a vitreous body attached to a retina without damaging the retina. Here, the safety vitreous body cutting device includes a tubular body part, a cutter part, and a safety net part. The tubular body part is formed in a cylindrical shape, negative pressure is provided at the inside, and an open hole is formed on the outer circumferential surface of a distal end. The cutter part reciprocates along the axial direction of the tubular body part at the inside of the tubular body part to cut the vitreous body introduced into the open hole. The safety net part is provided at the distal end of the tubular body part, and allows the vitreous body to pass through, but prevents the retina tissue from passing through.
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公开(公告)号：US12215136B2
公开(公告)日：2025-02-04
申请号：US18295631
申请日：2023-04-04
Inventor： Tai Gyu Kim , Hyun Jung Sohn , Su Eon Kim
IPC: A61K8/14 , A61K9/127 , A61K39/00 , C07K14/705 , C07K14/715 , C07K14/735 , C07K14/74 , C12N5/0783
Abstract: The present invention relates to an exosome for stimulating T cells and the pharmaceutical use thereof. Immune exosomes secreted from artificial antigen-presenting cells which express HLA, CD32, and co-stimulatory molecules CD32, CD80, CD83, and 4-1BBL are used to stimulate naive CD8+ T cells whereby preventive and therapeutic effects on tumors, pathogen infections, or autoimmune diseases can be provided.
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114.发明申请公开(公告)号：US20250025115A1
公开(公告)日：2025-01-23
申请号：US18833237
申请日：2023-01-12
Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION , GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION
Inventor： Sheen Woo LEE , Kwang Gi KIM
Abstract: An embodiment provides a method for measuring a femoral anterior angle and a tibial torsion angle by using artificial intelligence, the method comprising the steps of: (a) obtaining, by a CT scanner, 2D CT images of the femur, the tibia, and the malleolus of a patient; (b) storing, in a big-data unit, the 2D CT images transmitted from the CT scanner; (c) setting, by an artificial intelligence unit, a first baseline related to the femoral head and neck, a second baseline related to the lower femoral, a third baseline related to the upper tibial, and a fourth baseline related to the malleolus, on the basis of the 2D CT images; and (d) measuring, by an angle measurement unit, a femoral anterior angle formed between the first baseline and the second baseline, and a tibial torsion angle formed between the third baseline and the fourth baseline.
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公开(公告)号：US20250000701A1
公开(公告)日：2025-01-02
申请号：US18710298
申请日：2022-12-09
Inventor： Young Jung ROH
IPC: A61F9/008
Abstract: An example of a retinal laser device using control of the number of micropulses comprises: an SRT laser beam irradiation unit for emitting an SRT laser beam configured by a plurality of micropulses toward the retina; an imaging unit for generating a plurality of retinal images by photographing the eyeball in real time; an image processing unit for processing and comparing the plurality of retinal images transmitted from the imaging unit to confirm a visual change in the retina, caused by the SRT laser beam; an information processing unit for setting the number of micropulses, on the basis of the energy of a damaging SRT laser beam emitted to the retina when a visual change in the retina occurs in an SRT irradiation spot; and a control unit for controlling the operation of the SRT laser beam irradiation unit according to the number of micropulses.
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Patent Agency Ranking
公开(公告)号：US20240428952A1
公开(公告)日：2024-12-26
申请号：US18750890
申请日：2024-06-21
Inventor： Min Wook JOO
Abstract: A device and method for predicting a pathologic fracture in the proximal femur are disclosed. The device for predicting a pathologic fracture in the proximal femur according to an aspect of the present invention is a device for predicting a pathologic fracture in the proximal femur of an advanced cancer patient, including: a memory for storing one or more instructions; and a processor for executing the one or more instructions, wherein the processor can process a CT image including the femur of the cancer patient to generate an input image by executing the one or more instructions, input the input image into a fracture prediction artificial neural network model, and obtain prediction information about whether a pathologic fracture in the proximal femur will occur within a predetermined period from the time of acquiring the CT image which is output by the fracture prediction artificial neural network model.
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公开(公告)号：US20240409904A1
公开(公告)日：2024-12-12
申请号：US18737066
申请日：2024-06-07
Inventor： Sung Won KIM , Ayoung JO , Min Jae LIM
IPC: C12N5/071
Abstract: The present invention relates to a method of developing a tissue-specific vascular endothelial cell line based on iPSCs derived from human tissue-specific cells. When an organoid is manufactured using the cell line based on the iPSCs derived from human tissue-specific cells, the organoid manufacturing period may be significantly shortened, thereby solving the problem of sustainability, which is a major drawback known in the related art, and may be stored conveniently, and thus may be easily used during each experiment, thereby greatly increasing efficiency. Also, the organoid manufactured from the cell line of the present invention may be usefully used in the manufacture of blood vessel organoids in that the organoid is not only tissue-specific but also exhibits an excellent level of morphological and functional maturity.
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公开(公告)号：US12097385B2
公开(公告)日：2024-09-24
申请号：US17781842
申请日：2020-10-08
Inventor： Young Nam Kang , Tae Geon Oh , Yun Ji Seol , Na Young An , Jae Hyeon Lee , Chul Seung Kay , Jin Sol Shin , Jin Ho Hwang , Hun Joo Shin , Myung Ho Kim , Hong Seok Jang
IPC: A61N5/10
CPC classification number: A61N5/10 , A61N2005/1076
Abstract: A lung phantom unit for radiotherapy according to an embodiment of the present disclosure may arrange, at a location not affected by a magnetic field, a phantom driving cylinder and a driving device which may move a lung mimic and a tumor mimic in a lung simulation block. The lung phantom unit may be used for general purpose even as a phantom for MRI-based and CT image-based radiotherapy. Since lung and tumor motions are implemented by air injection, it may be possible to precisely measure the motion and volume change of a lung according to subtle changes in air pressure so that customized radiotherapy suitable for a patient having various breathing patterns is possible.
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公开(公告)号：US12089850B2
公开(公告)日：2024-09-17
申请号：US17630298
申请日：2021-07-29
Inventor： Sa Jin Kim , Jae Eun Shin
CPC classification number: A61B17/12136 , A61M25/1002 , A61M25/10181 , A61B2017/12004 , A61B2017/4216 , A61M2025/1086
Abstract: A hemostatic device is disclosed. The hemostatic device according to an embodiment of the present invention includes: a balloon which is expanded by a fluid supplied therein; a blood discharge pipe which includes a blood inflow hole at one end and exposes the other end to a lower side of the balloon wherein a certain section of a lower side of the blood inflow hole is surrounded by the balloon; and a fluid flow pipe communicating with the inside of the balloon for supplying or discharging the fluid and extending to a lower side of the balloon. The balloon includes a plurality of protrusions that are formed to protrude outward when the balloon is expanded by the fluid.
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120.发明公开公开(公告)号：US20240153075A1
公开(公告)日：2024-05-09
申请号：US18385925
申请日：2023-11-01
Inventor： Ju Hee HAN , Ji Ho PARK , Young-Min PARK , Ji-Hyun LEE , Chul Hwan BANG , Woo Hyup LEE , Jeong Wook MOON
CPC classification number: G06T7/0012 , G06T7/90 , G06T2207/20081 , G06T2207/30088
Abstract: The electronic device for recommending an AI-based melanoma biopsy site according to an exemplary embodiment of the present invention includes a processor which classifies a skin image that is input by using a classification model as melanoma or nevus, identifies melanoma features in the skin image by using a generation model when the skin image is classified as melanoma to generate an image from which the melanoma features are removed, and compares the skin image with the generated image to identify at least one candidate biopsy site.
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