公开(公告)号：US5891180A

公开(公告)日：1999-04-06

申请号：US69284

申请日：1998-04-29

申请人： Daniel R. Greeninger ,  David L. Thompson ,  Jerome T. Hartlaub

发明人： Daniel R. Greeninger ,  David L. Thompson ,  Jerome T. Hartlaub

IPC分类号： A61N1/372 ,  A61N1/362

CPC分类号： A61N1/37258

摘要： Methods and apparatus for interrogation of implantable medical device (IMD) information, including programmed parameter values, operating modes and programmed changes thereof and data stored in the IMD, by emission of audible sounds by the IMD are disclosed. The IMD includes an audio transducer that emits audible sounds including voiced statements or musical tones stored in analog memory correlated to a programming or interrogation operating algorithm or to a warning trigger event. The audible sounds can comprise the sole uplink transmission or may augment the contemporaneous uplink RF transmission of stored data, and/or programmed operating modes and parameters and/or device operations and states in an interrogation or during programming. To conserve energy, the audible sounds accompanying interrogation and programming of the IMD are at a low volume that preferably cannot be heard without use of an external audio amplifier or stethoscope. Voiced statements warning of battery energy depletion or imminent delivery of a therapy are emitted at a higher volume that is sufficient to be heard by the patient, so that the patient can take appropriate action. The volume of audible sounds confirming programmed changes made by a patient using a limited function programmer or magnet is also increased so that the patient can hear them.

摘要翻译： 公开了通过IMD发出可听见的声音来询问可植入医疗装置（IMD）信息的方法和装置，其中包括编程参数值，操作模式及其编程改变以及存储在IMD中的数据。 IMD包括音频换能器，其发射可听声音，包括存储在与编程或询问操作算法相关的模拟存储器中的语音或音调，或者到警告触发事件。 可听见的声音可以包括唯一的上行链路传输，或者可以在询问中或在编程期间增加存储数据的同时期上行链路RF传输和/或编程的操作模式和参数和/或设备操作和状态。 为了节省能量，伴随着IMD的询问和编程的可听见的声音处于较低的音量，最好在不使用外部音频放大器或听诊器的情况下听不到声音。 电池能量消耗或治疗即将发送的声明声明以足以由患者听到的较高音量发出，以便患者能够采取适当的动作。 使用有限功能的编程器或磁铁确认病人进行的编程改变的可听见声音的音量也增加，以便患者可以听到它们的声音。

公开(公告)号：US5752976A

公开(公告)日：1998-05-19

申请号：US494218

申请日：1995-06-23

申请人： Edwin G. Duffin ,  David L. Thompson ,  Steven D. Goedeke ,  Gregory J. Haubrich

发明人： Edwin G. Duffin ,  David L. Thompson ,  Steven D. Goedeke ,  Gregory J. Haubrich

IPC分类号： A61B5/00 ,  A61N1/37 ,  A61N1/372 ,  H04Q7/38 ,  H04Q9/00

CPC分类号： A61N1/37282 ,  G06F19/3418 ,  A61B5/1112

摘要： A system and method for communicating with a medical device implanted in an ambulatory patient and for locating the patient in order to selectively monitor device function, alter device operating parameters and modes and provide emergency assistance to and communications with a patient. The implanted device includes a telemetry transceiver for communicating data and operating instructions between the implanted device and an external patient communications control device that is either worn by or located in proximity to the patient within the implanted device transceiving range. The control device preferably includes a communication link with a remote medical support network, a global positioning satellite receiver for receiving positioning data identifying the global position of the control device, and a patient activated link for permitting patient initiated personal communication with the medical support network. A system controller in the control device controls data and voice communications for selectively transmitting patient initiated personal communications and global positioning data to the medical support network, for initiating telemetry out of data and operating commands from the implanted device and transmission of the same to the medical support network, and for receiving and initiating re-programming of the implanted device operating modes and parameters in response to instructions received from the medical support network. The communications link between the medical support network and the patient communications control device may comprise a world wide satellite network, hard-wired telephone network, a cellular telephone network or other personal communications system.

摘要翻译： 一种用于与植入在步行病人中的医疗设备进行通信并用于定位患者的系统和方法，以便选择性地监测设备功能，改变设备操作参数和模式，并向患者提供紧急援助和与患者通信。 植入装置包括遥测收发器，用于在植入的装置和外部患者通信控制装置之间传送数据和操作指令，所述外部患者通信控制装置在植入装置收发范围内由患者佩戴或位于患者附近。 控制装置优选地包括与远程医疗支持网络的通信链路，用于接收标识控制装置的全局位置的定位数据的全球定位卫星接收机，以及用于允许患者发起与医疗支持网络的个人通信的患者激活的链路。 控制装置中的系统控制器控制数据和语音通信，用于选择性地将患者发起的个人通信和全球定位数据发送到医疗支持网络，用于发起远程数据和从植入设备的操作命令并将其传输到医疗 支持网络，以及响应于从医疗支持网络接收到的指令，接收和启动植入设备操作模式和参数的重新编程。 医疗支持网络和患者通信控制设备之间的通信链路可以包括全球卫星网络，硬连线电话网络，蜂窝电话网络或其他个人通信系统。

公开(公告)号：US5402569A

公开(公告)日：1995-04-04

申请号：US202360

申请日：1994-02-28

申请人： Bruce A. Maki ,  David L. Thompson

发明人： Bruce A. Maki ,  David L. Thompson

IPC分类号： F01C21/10 ,  B23P15/00

CPC分类号： F01C21/106 ,  Y10T29/49236 ,  Y10T29/49245 ,  Y10T29/49893

摘要： An improved method for manufacturing a sophisticated cam profile liner used in pumps and compressors. A non-circular cam profile liner is fabricated from multiple parts, preferably two identical cam liner halves mated together. Each cam profile liner half is generally crescent-shaped, and is manufactured from a single mold using conventional molding techniques. Window openings are formed in the cam profile liner without the need for hand-placing inserts in the mold. Further, no taper is formed in the cam profile liner. Accordingly, the present invention is suitable for use in precision sliding vane pumps, as well as flexible and roller-type pumps. Since each cam profile liner half is identical to the other, a symmetrical cam chamber is defined by the cam profile liner.

摘要翻译： 一种用于制造用于泵和压缩机的精密凸轮轮廓衬套的改进方法。 非圆形凸轮轮廓衬套由多个部件制成，优选地两个相同的凸轮衬套半部配合在一起。 每个凸轮轮廓衬里半部通常是月牙形，并且使用常规模制技术由单个模具制造。 窗口开口形成在凸轮轮廓衬里中，而不需要在模具中的手动放置插入件。 此外，凸轮轮廓衬里中没有形成锥形。 因此，本发明适用于精密滑动叶片泵以及柔性和辊式泵。 由于每个凸轮轮廓衬垫半部分与另一个相同，所以凸轮轮廓衬套限定了对称的凸轮室。

公开(公告)号：US5374282A

公开(公告)日：1994-12-20

申请号：US786134

申请日：1991-10-31

申请人： Lucy M. Nichols ,  Glenn M. Roline ,  Tom D. Bennett ,  David L. Thompson

发明人： Lucy M. Nichols ,  Glenn M. Roline ,  Tom D. Bennett ,  David L. Thompson

IPC分类号： A61N1/365 ,  A61N1/37

CPC分类号： A61N1/37 ,  A61N1/36564

摘要： A pacemaker capable of automatically adjusting the sensitivity of its sense amplifier to electrical cardiac signals is disclosed. In one embodiment, a pacemaker having a pressure sensor disposed on the distal end of its pacing/sensing lead counts the number of pressure events and electrical events which occur during an autosensitivity timing period. If the number of electrical events exceeds the number of pressure events by more than a predetermined margin, the sense amplifier's sensitivity threshold is decreased. If the number of electrical events does not exceed the number of pressure events by more than the predetermined margin, the sense amplifier's sensitivity threshold is increased. In another embodiment, the pacemaker maintains a running average of the peak voltages of sensed electrical events over a predetermined history period. Periodically, the pacemaker computes the ratio of the running average of peak voltages to a preprogrammed sense margin value, and adjusts the sensitivity threshold of the sense amplifier according to this computation. By basing the adjustment of the sense amplifier's sensitivity threshold on a long-term average of peak sense values, the effects of cycle-to-cycle variation in sensed values are minimized. In still another embodiment of the invention, a pressure sensor alone is employed to detect natural cardiac events.

摘要翻译： 公开了能够自动调整其感测放大器对电心电信号的灵敏度的起搏器。 在一个实施例中，具有设置在其起搏/感测引线的远端上的压力传感器的起搏器对在自动感应定时周期期间发生的压力事件和电气事件的数量进行计数。 如果电气事件的数量超过压力事件的数量超过预定的余量，则读出放大器的灵敏度阈值降低。 如果电气事件的数量不超过压力事件的数量超过预定的余量，则读出放大器的灵敏度阈值增加。 在另一个实施例中，起搏器在预定历史时段内保持感测到的电气事件的峰值电压的运行平均值。 定期地，起搏器计算峰值电压的运行平均值与预编程感测余量值的比率，并根据该计算调整读出放大器的灵敏度阈值。 通过将感测放大器的灵敏度阈值的调整基于峰值感测值的长期平均值，将感测值中的周期与周期变化的影响最小化。 在本发明的另一个实施例中，单独使用压力传感器来检测自然心脏事件。

公开(公告)号：US5344431A

公开(公告)日：1994-09-06

申请号：US944872

申请日：1992-09-14

申请人： Donald R. Merritt ,  William G. Howard ,  Paul M. Skarstad ,  Douglas J. Weiss ,  Paul B. Wyborny ,  Glenn M. Roline ,  Lucy M. Nichols ,  David L. Thompson

发明人： Donald R. Merritt ,  William G. Howard ,  Paul M. Skarstad ,  Douglas J. Weiss ,  Paul B. Wyborny ,  Glenn M. Roline ,  Lucy M. Nichols ,  David L. Thompson

IPC分类号： A61N1/372 ,  A61N1/00

CPC分类号： A61N1/3727 ,  A61N1/3708 ,  A61N1/37211 ,  A61N1/378 ,  Y10S128/903

摘要： A method and apparatus for determination of battery end-of-service in a medical device in which the medical device comprises a cathode limited electrochemical cell having an active metal anode and a manganese dioxide cathode and means for digital telemetry of cell voltage. The sloped, well defined voltage curve of such a cell during cell discharge combined with precise information available through digital telemetry allows for improved determination of battery end-of-service for the medical device.

摘要翻译： 一种用于确定医疗装置中的电池服务终了的方法和装置，其中所述医疗装置包括具有活性金属阳极和二氧化锰阴极的阴极限制电化学电池以及用于电池电压的数字遥测的装置。 电池放电期间这种电池的倾斜，明确定义的电压曲线与通过数字遥测获得的精确信息相结合，可以改善医疗设备的电池服务终了时间。

公开(公告)号：US5330513A

公开(公告)日：1994-07-19

申请号：US881996

申请日：1992-05-01

申请人： Lucy M. Nichols ,  Glenn M. Roline ,  Tom D. Bennett ,  David L. Thompson

发明人： Lucy M. Nichols ,  Glenn M. Roline ,  Tom D. Bennett ,  David L. Thompson

IPC分类号： A61N1/365 ,  A61N1/372 ,  A61N5/00

CPC分类号： A61N1/36585 ,  A61N1/37211

摘要： An implantable physiologic device, e.g., a multi-programmable, microprocessor based cardiac pacemaker, is provided with data storage and transmission capabilities for transmitting out certain current operating parameters and sensed events and for storing counted events for transmission of counts, histograms and real-time clock data out on command. The device preferably comprises a rate responsive cardiac pacemaker for providing an optimized pacing rate of stimulation pulses as a function of at least one selected rate control parameter. Each rate control parameter has a value which varies as a function of changes in a patient's physiologic demand and includes a sensor system for sensing the rate control parameter value and for providing a sensor output representative thereof. The cardiac pacemaker also includes control circuitry which includes a rate response defining means for deriving desired pacing rates as a function of the sensor output signal(s) modified by sensor gain and selective weighting coefficient values. An achievement monitoring means that has a predetermined achievement criterion monitors the relationship between the derived pacing rates and the achievement criterion over an optimization period. Output circuitry providing optimized pacing rates as a function of optimization is accomplished by adjusting the rate response gain for each sensor as a function of the monitored achievement relationship. Another optimization function is provided by adjusting a sensor weighting coefficient value which weights or regulates the relative contribution each sensor's derived desired pacing rates will contribute toward the pacemaker-derived optimized pacing rate.

摘要翻译： 可植入生理装置，例如基于多可编程微处理器的心脏起搏器，具有数据存储和传输能力，用于发送某些当前操作参数和检测到的事件，并存储用于计数，直方图和实时传输的计数事件 时钟数据输出命令。 该装置优选地包括速率响应心脏起搏器，用于提供作为至少一个选择的速率控制参数的函数的刺激脉冲的优化起搏速率。 每个速率控制参数具有根据患者生理需求的变化而变化的值，并且包括用于感测速率控制参数值并用于提供代表其的传感器输出的传感器系统。 心脏起搏器还包括控制电路，其包括用于根据由传感器增益和选择性加权系数值修改的传感器输出信号导出所需起搏速率的速率响应定义装置。 具有预定成就标准的成就监视装置在优化期间监视所得出的起搏速率与成就标准之间的关系。 通过根据监测的成就关系调整每个传感器的速率响应增益来实现提供作为优化功能的优化起搏速率的输出电路。 通过调整传感器加权系数值来提供另一个优化功能，传感器加权系数值对每个传感器的推导的所需起搏速率对起搏器导出的优化起搏速率有贡献的相对贡献进行加权或调节。

公开(公告)号：US5282839A

公开(公告)日：1994-02-01

申请号：US949414

申请日：1992-12-14

申请人： Glenn M. Roline ,  Lucy M. Nichols ,  David L. Thompson ,  Tommy D. Bennett

发明人： Glenn M. Roline ,  Lucy M. Nichols ,  David L. Thompson ,  Tommy D. Bennett

IPC分类号： A61N1/365

CPC分类号： A61N1/36585

摘要： A rate responsive cardiac pacemaker for providing an optimized pacing rate of stimulation pulses as a function of at least one selected rate control parameter. Each rate control parameter has a value which varies as a function of changes in a patient's physiologic demand and includes a sensor system for sensing the rate control parameter value and for providing a sensor output representative thereof. The cardiac pacemaker also includes a rate response defining means for deriving desired pacing rates as a function of the sensor output, an achievement monitoring means that has a predetermined achievement criterion (primary criterion), for monitoring the relationship between the derived pacing rates and the achievement criterion over an optimization period, and either one of Average Activity level or Average Activity Difference level monitoring means that has a corresponding predetermined minimum and a predetermined maximum Average Activity level or Average Activity Difference level (secondary criterion), for monitoring the relationship between the derived pacing rates and the secondary criterion over an optimization period. Another optimization function is provided by adjusting a sensor weighting value which weights or regulates the relative contribution each sensor's derived desired pacing rates will contribute toward the pacemaker-derived optimized pacing rates.

摘要翻译： 一种速率响应心脏起搏器，用于提供作为至少一个选择的速率控制参数的函数的刺激脉冲的优化起搏速率。 每个速率控制参数具有根据患者生理需求的变化而变化的值，并且包括用于感测速率控制参数值并用于提供代表其的传感器输出的传感器系统。 心脏起搏器还包括用于根据传感器输出导出所需起搏速率的速率响应定义装置，具有预定成就标准（主要标准）的成就监测装置，用于监测所获得的起搏速率与成就之间的关系 标准，并且平均活动水平或平均活动差异水平监测中的任一个意味着具有相应的预定最小值和预定的最大平均活动水平或平均活动差异水平（次级标准），用于监测所导出的 起搏速度和优化期的次要标准。 通过调整传感器权重值来提供另一个优化功能，该权重值权重或调节每个传感器的推导的所需起搏速率对起搏器导出的优化起搏速率有贡献的相对贡献。

公开(公告)号：US4951667A

公开(公告)日：1990-08-28

申请号：US450958

申请日：1989-12-12

申请人： H. Toby Markowitz ,  Kevin Prest-Berg ,  David L. Thompson

发明人： H. Toby Markowitz ,  Kevin Prest-Berg ,  David L. Thompson

IPC分类号： A61N1/365 ,  A61N1/368

CPC分类号： A61N1/368 ,  A61N1/36514

摘要： An activity responsive, rate adaptive pacer, which senses and paces in both the atrium and ventricle is disclosed. The pacing rate displayed by the pacer is determined by the sensed activity of the patient, the programmed lower rate, and the patient's atrial or sinus rate.

公开(公告)号：US4903084A

公开(公告)日：1990-02-20

申请号：US327850

申请日：1989-03-23

申请人： Leon A. Baltrus ,  Clyde M. Creveling ,  Donald G. McKeown ,  Thomas E. Reding ,  David L. Thompson ,  Francisco L. Ziegelmuller

发明人： Leon A. Baltrus ,  Clyde M. Creveling ,  Donald G. McKeown ,  Thomas E. Reding ,  David L. Thompson ,  Francisco L. Ziegelmuller

IPC分类号： G03G21/00

CPC分类号： G03G21/0035 ,  G03G2221/0005

摘要： The inner diameter of a single and compact external dusthood that houses the fiber brush of a brush-vacuum cleaning apparatus, is made to be substantially less than the average outer diameter of such fiber brush, thereby creating a substantial interference fit of the brush with the inside of such an external dusthood. The substantial interference contact between the brush and the inside of the external dusthood is such that any open or free air passage ways or air pockets between the brush and the external dusthood are eliminated, and such that toner particles removed by the brush from an image bearing surface are immediately entrained and carried (through the external dusthood) against the inside wall of such external dusthood, thereby preventing such particles from ever becoming airborne, or building up anywhere within the external dusthood.

摘要翻译： 容纳毛刷真空清洁装置的纤维刷的单一和紧凑的外部灰尘的内径被制成大大小于这种纤维刷的平均外径，从而使刷子与 在这样的外部尘埃里面。 电刷和外部粉尘的内部之间的实质干涉接触使得刷子和外部灰尘之间的任何开放或自由的空气通道或气囊被消除，并且使得由电刷从图像承载 表面立即夹带并携带（通过外部灰尘）抵靠这种外部灰尘的内壁，从而防止这种颗粒飞行，或在外部灰尘中的任何地方建立。

公开(公告)号：US4381010A

公开(公告)日：1983-04-26

申请号：US250640

申请日：1981-04-03

申请人： David L. Thompson ,  Donald W. Zobel

发明人： David L. Thompson ,  Donald W. Zobel

IPC分类号： A61N1/365 ,  A61N1/372 ,  A61N1/36

CPC分类号： A61N1/365 ,  A61N1/37211

摘要： An implantable heart pacemaker having digital injection integrated circuitry includes a bias switch (70) operative to turn on or increase the bias current to the pulse width logic (50) just prior to an output pulse. Increased bias to the pulse width logic permits high speed operation of the logic to accurately terminate the output pulse at the end of the desired pulse duration. At the end of the output pulse, the bias switch is turned off to return the bias current to a low quiescent value, and in some cases is turned completely off, to conserve battery power. The logic gates used in the pulse width logic are arrayed along one or more current injector "bars" or "rails" formed in the integrated circuit, and the bias switch (70) is connected for controlling the current delivered to those current injectors, so that increased bias need only be supplied to the circuits requiring high switching speed.

摘要翻译： 具有数字注入集成电路的可植入心脏起搏器包括偏置开关（70），其在刚好在输出脉冲之前操作以将偏置电流接通或增加到脉冲宽度逻辑（50）。 对脉冲宽度逻辑的增加的偏置允许逻辑的高速操作以在期望的脉冲持续时间结束时精确地终止输出脉冲。 在输出脉冲结束时，偏置开关被关闭，将偏置电流恢复到低静态值，并且在某些情况下完全关闭，以节省电池电量。 在脉冲宽度逻辑中使用的逻辑门沿着形成在集成电路中的一个或多个电流注入器“条”或“轨”排列，偏置开关（70）被连接用于控制输送到那些电流注入器的电流，因此 增加的偏压仅需要提供给需要高开关速度的电路。