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1671 条记录 (耗时 0.043 秒)

    NON-INVASIVE BLOOD BASED MONITORING OF GENOMIC ALTERATIONS IN CANCER
    123.
    发明申请
    NON-INVASIVE BLOOD BASED MONITORING OF GENOMIC ALTERATIONS IN CANCER 有权

    公开(公告)号：US20210207223A1

    公开(公告)日：2021-07-08

    申请号：US17096817

    申请日：2020-11-12

    申请人： Dana-Farber Cancer Institute, Inc.

    发明人： Pasi A. Janne ,  Cloud P. Paweletz ,  Geoffrey Oxnard ,  Yanan Kuang

    IPC分类号： C12Q1/6886 ,  C12Q1/6827 ,  A61K31/437 ,  A61K31/517

    摘要： The invention provides methods to monitor cell free nucleic acids. The method comprises obtaining a plasma sample from a subject known to have a cancer characterized by a pair of mutually exclusive mutations specific to the cancer; isolating cell free nucleic acids from the plasma sample obtained from the subject; measuring the amount a housekeeping gene and/or total DNA in the cell free nucleic acids isolated from the plasma sample to confirm that the amount of housekeeping gene and/or total DNA in the sample is within a selected range; measuring the amount of a first of the pair of mutually exclusive mutations specific to the cancer in the cell free nucleic acids isolated from the plasma sample; and indicating in a report that the subject has the first mutation when (a) the amount of the housekeeping gene and/or total DNA in the cell free nucleic acids isolated from the plasma sample is within the selected range and (b) the amount of the first mutation is increased as compared to a control amount, wherein the control amount is determined by measuring the apparent amount of the first mutation in control cell free nucleic acids isolated from plasma samples obtained from control subjects known to have the second of the pair of mutually exclusive mutations specific to the cancer using measuring conditions substantially the same as those used to measure the amount of the first mutation in the cell free nucleic acids isolated from the plasma sample from the subject.

    CYANO THIENOTRIAZOLODIAZEPINES AND USES THEREOF
    124.
    发明申请
    CYANO THIENOTRIAZOLODIAZEPINES AND USES THEREOF 有权

    公开(公告)号：US20210206779A9

    公开(公告)日：2021-07-08

    申请号：US15758822

    申请日：2016-09-09

    申请人： Dana-Farber Cancer Institute, Inc.

    发明人： James E. Bradner ,  Jun Qi ,  Minoru Tanaka ,  Dennis Buckley

    IPC分类号： C07D495/14

    摘要： The present invention provides compounds and pharmaceutically compositions thereof. The compounds and compositions are binders of bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (BET) proteins). Also provided are methods, uses, and kits using the compounds and pharmaceutical compositions for inhibiting the activity (e.g., increased activity) of bromodomains and/or bromodomain-containing proteins and for treating and/or preventing in a subject diseases associated with bromodomains or bromodomain-containing proteins (e.g., proliferative diseases, cardiovascular diseases, viral infections, fibrotic diseases, metabolic diseases, endocrine diseases, and radiation poisoning). The compounds, pharmaceutical compositions, and kits are also useful for male contraception.

    IMIDAZOLYL KINASE INHIBITORS AND USES THEREOF
    128.
    发明申请
    IMIDAZOLYL KINASE INHIBITORS AND USES THEREOF 有权

    公开(公告)号：US20210147388A1

    公开(公告)日：2021-05-20

    申请号：US17155244

    申请日：2021-01-22

    申请人： Dana-Farber Cancer Institute, Inc.

    发明人： Nathanael S. Gray ,  Hwan Geun Choi ,  Yanke Liang

    IPC分类号： C07D403/04 ,  C07D403/14

    摘要： The present disclosure provides imidazolyl compounds of Formula (I) and methods of preparing the compounds. The provided compounds are able to bind protein kinases and may be useful in modulating (e.g., inhibiting) the activity of a protein kinase in a subject or cell and/or in treating or preventing a disease (e.g., proliferative disease, genetic disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder) in a subject in need thereof. Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve a compound described herein.