公开(公告)号：US10759750B2

公开(公告)日：2020-09-01

申请号：US16096830

申请日：2017-04-27

Applicant: Temple University—Of The Commonwealth System of Higher Education

Inventor： Magid A. Abou-Gharbia ,  Benjamin E. Blass ,  Wayne E. Childers ,  Mercy Ramanjulu ,  George C. Morton

IPC: C07D401/06 ,  C07D403/06 ,  C07D205/08 ,  A61K31/397 ,  C07D487/10 ,  C07D471/10 ,  C07D403/12 ,  A61P25/14 ,  A61P25/28 ,  A61P25/30 ,  C07D401/12 ,  C07D471/04 ,  C07D487/04

Abstract: Pharmaceutical compositions of the invention comprise compounds, compositions, methods useful for the treatment of drug addiction, drug withdrawal, and diseases or conditions that involve dysregulation of glutamate homeostasis in its etiology.

公开(公告)号：US10729670B2

公开(公告)日：2020-08-04

申请号：US16331489

申请日：2017-09-07

Applicant: Temple University—Of The Commonwealth System Of Higher Education

Inventor： Salim Merali ,  Carlos A. Barrero ,  Wayne E. Childers ,  George C. Morton

IPC: A61K31/198 ,  A61P3/08

Abstract: Compounds of Formula (I), and pharmaceutically effective salts thereof; wherein R1-R14, m, n, o, p, q and r are as defined herein, are provided for treatment of for increasing insulin sensitivity, reducing insulin resistance, preventing insulin resistance and treating insulin resistance disorders.

公开(公告)号：US20200185158A1

公开(公告)日：2020-06-11

申请号：US16345829

申请日：2017-10-31

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Yi Rao ,  Bradford B. Wayland ,  Hai-Lung Dai ,  Xia Li

IPC: H01G9/20 ,  H01L51/00 ,  H01G9/00 ,  H01L51/42 ,  C03C17/00

Abstract: The present invention relates in part to short-wave IR (SWIR) materials comprising generic mixed salts of empirical formula AaBbMcXd that are composition-dependent, broadband, and tunable. These materials have unique light absorbance wavelengths from 0.4 to 2.6 μm, including both the visible and SWIR. The preparation procedure for the SWIR materials is simple, including the use of widely available, cheap, and non-toxic precursors, unlike existing state of the art alloy SWIR materials. These novel materials have broad applications in security, surveillance, military, machine vision, photovoltaic solar cells, medical treatments, spectroscopy detector, and thermography. The present invention also relates to methods of fabricating a film comprising the composition of the invention and to photovoltaic stacks comprising the composition of the invention.

公开(公告)号：US20200166517A1

公开(公告)日：2020-05-28

申请号：US16631969

申请日：2018-07-18

Applicant: Temple University-Of The Commonwealth System of Higher Education ,  Shriners Hospitals for Children

Inventor： Gareth M. Thomas ,  Dale D.O. Martin ,  Sabrina Marion Holland ,  Jingwen Niu ,  Marlene A. Jacobson ,  Wayne E. Childers

IPC: G01N33/58 ,  G01N33/68 ,  G01N33/573

Abstract: The present invention provides compositions and methods for identifying modulators of palmitoylation and uses thereof.

公开(公告)号：US10647671B2

公开(公告)日：2020-05-12

申请号：US16091685

申请日：2017-04-18

Applicant: Temple University—Of The Commonwealth System of Higher Education

Inventor： William M. Wuest

IPC: C07D207/12 ,  A61K31/40 ,  C07D207/24 ,  A61P31/04 ,  A61K45/06 ,  A61K31/401

Abstract: The present invention includes novel analogs of promysalin useful in preventing or treating a microbial infection. The present invention also includes methods preventing or treating a microbial infection in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of the invention.

公开(公告)号：US20200038248A1

公开(公告)日：2020-02-06

申请号：US16339955

申请日：2017-10-05

Applicant: Temple University- Of the Commonwealth System of Higher Education

Inventor： Azadeh Timnak ,  Jonathan A. Gerstenhaber ,  Yah-el H. Har-el ,  Peter I. Lelkes

IPC: A61F13/00 ,  A61M1/00 ,  A61F13/36 ,  A61L15/40 ,  A61L15/44 ,  A61F13/15

Abstract: The present invention provides methods for improving negative pressure wound therapy. The application of negative pressure to a wound bed with a biodegradable biocompatible fibrous scaffold facilitates cell infiltration into the scaffold serving as a 3D structure, as opposed to solely application of the scaffold without any pressure, which shows minimal cell penetration. In vitro studies show that infiltration of immune cells into scaffolds paves the way for their polarization towards the phenotype pertinent to the remodeling stage 2. The cell penetration factor causes less intense immune response of the host body, leading the inflammation to proceed to the remodeling stage.

公开(公告)号：US20200002729A1

公开(公告)日：2020-01-02

申请号：US16568771

申请日：2019-09-12

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Oscar M. Perez-Leal

IPC: C12N15/90 ,  C12N15/85 ,  C12N5/16 ,  C12N5/07

Abstract: The present invention provides homologous recombination vectors to insert transgenic DNA in cells. These vectors shorten the production time and allow for easy generation of genetically modified cells. The invention allows the user to test multiple tags and to generate homozygous modified cell line using the homologous recombination vector. The invention can be used to generate knockout cells, to generate cell lines with knockin genes, to generate cell lines for drug screening against any target, to create transgenic animals, or in gene therapy.

公开(公告)号：US20190380638A1

公开(公告)日：2019-12-19

申请号：US16479910

申请日：2018-01-16

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： William Geoffrey Wright

IPC: A61B5/00 ,  A61B5/11 ,  G06F3/01 ,  G06T19/00

Abstract: A method of assessing the balance impairment of a subject includes the steps of presenting the subject with a static scene on a display, collecting a first set of orientation measurements, presenting the subject with an unstable scene on a display, collecting a second set of orientation measurements, storing the first and second sets of orientation measurements on a computing device, referenced to a set of time indices, and calculating a balance score for the subject by comparing the second set of orientation measurements with the first set of orientation measurements. A system for assessing the balance impairment of a subject is also disclosed.

公开(公告)号：US20190367528A1

公开(公告)日：2019-12-05

申请号：US16349811

申请日：2017-11-15

Applicant: Temple University-Of The Commonwealth System of Higher Education ,  Praeventix, LLC

Inventor： Daniel J. Canney ,  Benjamin E. Blass ,  Kevin M. Blattner ,  Douglas A. Pippin

IPC: C07D491/107 ,  C07D221/00 ,  C07D309/08 ,  C07D493/10 ,  C07D513/04 ,  C07D295/073 ,  C07D413/10 ,  C07F7/10

Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

公开(公告)号：US20190352713A1

公开(公告)日：2019-11-21

申请号：US16417987

申请日：2019-05-21

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Xiao-Feng Yang

IPC: C12Q1/6876 ,  C12Q1/6806 ,  C12Q1/686

Abstract: The invention provides compositions and methods for the diagnosis, treatment, assessment, and characterization of hyperlipidemia-related diseases and disorders, including atherosclerosis, non-alcoholic fatty liver disease, obesity and diabetes mellitus in a subject in need thereof, based on the expression level of at least one miRNA that is associated with these diseases and disorders.