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公开(公告)号:US20210355170A1
公开(公告)日:2021-11-18
申请号:US17318719
申请日:2021-05-12
Inventor: Timothy Whitehead , Monica Kirby , Zachary Baumer , Matthew Bedewitz , Brian Petersen , Paul J. Steiner
IPC: C07K14/005 , C12N15/81
Abstract: The invention relates to one or more mutations configured to stabilize the prefusion “up” protomer trimeric Spike protein from SARS-CoV-2. The inventive technology further relates to systems, methods, and compositions to display one or more proteins on the surface of a yeast cell. Specifically, in one embodiment the invention relates to systems, methods, and compositions to display one or more Spike protein from SARS-CoV-2 on the surface of a yeast cell, and more preferably a Spike protein from SARS-CoV-2 stabilized in its prefusion conformation on the surface of a yeast cell.
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公开(公告)号:US11160908B2
公开(公告)日:2021-11-02
申请号:US16705989
申请日:2019-12-06
Inventor: Jeffrey Olson
Abstract: The present disclosure provides an implantable device comprising a substrate capable of capturing an intraocular target molecule and to methods of use thereof.
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公开(公告)号:US20210322213A1
公开(公告)日:2021-10-21
申请号:US17244595
申请日:2021-04-29
Inventor: Malik Kahook
Abstract: This invention is in the field of medical intervention related to the lacrimal system. The invention relates to a lacrimal system device and methods of using the device for drug delivery to the eye, sinuses and/or periocular tissues.
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公开(公告)号:US20210315878A1
公开(公告)日:2021-10-14
申请号:US17284545
申请日:2019-10-15
Inventor: Craig JORDAN , Clayton SMITH , Courtney L. JONES , Brett STEVENS
IPC: A61K31/4545 , A61K45/06 , A61K31/635 , A61K31/336 , A61K31/55 , A61K31/706 , A61P35/02
Abstract: The present disclosure relates to compositions and methods for reducing cancer stem cells. In some aspects, the compositions and methods can comprise at least one metabolism modulating agent. In other aspects, the compositions and methods can comprise at least two metabolism modulating agents.
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公开(公告)号:US20210307589A1
公开(公告)日:2021-10-07
申请号:US17354090
申请日:2021-06-22
Inventor: Mark E. Rentschler , Steven A. Edmundowicz , Karl Johannes
Abstract: A medical device includes an elongate body and an inflatable balloon attached to and partially surrounding at least a section of the elongate body. The inflatable balloon is selectively inflatable between a deflated state and an inflated state. Engagement between the balloon and a physiological lumen is provided, in part, by multiple protrusions extending from the inflatable balloon and having various physical and functional characteristics. In certain implementations, the balloon may be configured to exhibit various separation forces by applying different strains to the balloon, such as by varying the degree to which the balloon is inflated or deflated.
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公开(公告)号:US20210299114A1
公开(公告)日:2021-09-30
申请号:US17199896
申请日:2021-03-12
Inventor: Ram H. Nagaraj , Rooban B. Nahomi , Mi-hyun Nam
Abstract: Methods of treating, reducing the risk of, preventing, or alleviating at least one symptom of a retinal disease, injury, or condition in a subject involve administering a pharmaceutically effective amount of kynurenic acid to the subject. The kynurenic acid may be administered intravenously or intravitreally. Systems for treating retinal diseases, injuries, or conditions are also disclosed and may include an administration device.
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127.
公开(公告)号:US20210293643A1
公开(公告)日:2021-09-23
申请号:US17257715
申请日:2019-07-05
Inventor: Nikolaus Correll , Radhen Patel , Jacob Segil , John Klingner , Richard F. Weir
Abstract: Various embodiments of the present technology generally relate to robotics and prosthetics. More specifically, some embodiments of the present technology relate to multi-modal fingertip sensors with proximity, contact, and for localization capabilities. Various embodiments of the present technology provide for a novel multi-modal tactile sensor which comprises an infrared proximity sensor and a barometric pressure sensor embedded in an elastomer layer. Signals from both of these sensors can be fused to measure proximity (0-10 mm), contact (0N), force (0-50N) and localize impact at five spatial locations and three angles of incidence. Gaussian processes in a regression setting can be used to obtain calibrated force measurements with an R-squared value of 0.99. Supervised machine learning approaches can be used to localize the position and direction of probing with classification accuracies of 96% and 89% respectively.
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公开(公告)号:US20210275659A1
公开(公告)日:2021-09-09
申请号:US17125422
申请日:2020-12-17
Inventor: Christopher A. Lowry , Matthew G. Frank , Laura Fonken , Steven F. Maier
IPC: A61K39/04 , A61K35/741
Abstract: Methods of treating or preventing stress, anxiety, or postoperative cognitive dysfunction. Also provided are methods of improving resilience in a subject by administering a therapeutically effective amount of isolated Mycobacterium.
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公开(公告)号:US20210272771A1
公开(公告)日:2021-09-02
申请号:US17186835
申请日:2021-02-26
Inventor: Kieran Wilson , Miles Bengtson , Hanspeter Schaub , Dalton Turpen
IPC: H01J37/305 , H01J37/065
Abstract: Various embodiments of the present technology generally relate to devices and methods for generating and directing energetic electrons toward a target. More specifically, some embodiments relate to devices, systems, and methods for generating and directing energetic electrons based in the photoelectric effect and directing electric field-focused beams of the energetic electrons toward a target. Electron guns according to the present technology include one or more light sources to stimulate electron transmission, and a series of differentially charged stages to provide a hollow path allowing electrons generated by the photoelectric effect of the light irradiated on interior surfaces defining the path through the stages to travel to an exit of the electron gun. Each of the differentially charged stages have a different potential, thereby providing electrons having two or more different and tunable energy levels exiting as a beam from the electron gun.
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公开(公告)号:US20210255356A1
公开(公告)日:2021-08-19
申请号:US16003201
申请日:2018-06-08
Inventor: Tam Vu , Richard Han , Phuc Nguyen , Hoang Truong , Mahesh Kumar Ravindranathan
Abstract: One aspect of the invention provides a device for passive detection of the presence of a drone. The device includes: an antenna; a receiver in communication with the antenna to passively receive wireless signals; and a processor in communication with the receiver and programmed to determine whether a drone is present based on a pattern in the wireless signals emitted from the drone that is correlated with a physical movement of the drone. Another aspect of the invention provides a method for passively detecting the presence of a drone. The method includes: receiving a wireless signal at a device comprising an antenna, a receiver and a processor; and analyzing the wireless signal to determine whether the wireless signal includes a pattern in the signal that is indicative of a physical movement of a drone.
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