公开(公告)号：US07521561B2

公开(公告)日：2009-04-21

申请号：US11449004

申请日：2006-06-07

Applicant: Mathai Mammen ,  Adam Hughes ,  Yan Chen

Inventor： Mathai Mammen ,  Adam Hughes ,  Yan Chen

IPC: C07D215/38 ,  A61K31/44

CPC classification number: C07D211/46 ,  A61K31/445 ,  A61K31/452 ,  C07D211/48 ,  C07D211/58 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D453/02 ,  C07D471/08 ,  G01N33/9433

Abstract: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.

公开(公告)号：US07514558B2

公开(公告)日：2009-04-07

申请号：US11604607

申请日：2006-11-27

Applicant: Mathai Mammen ,  Adam Hughes ,  Eric Stangeland ,  Yan Chen

Inventor： Mathai Mammen ,  Adam Hughes ,  Eric Stangeland ,  Yan Chen

IPC: A61K31/44 ,  C07D215/38

CPC classification number: C07D211/46 ,  A61K31/445 ,  A61K31/452 ,  C07D211/48 ,  C07D211/58 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D453/02 ,  C07D471/08 ,  G01N33/9433

Abstract: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.

公开(公告)号：US07507751B2

公开(公告)日：2009-03-24

申请号：US11888526

申请日：2007-08-01

Applicant: Mathai Mammen ,  Adam Hughes ,  Yan Chen

Inventor： Mathai Mammen ,  Adam Hughes ,  Yan Chen

IPC: A61K31/47

CPC classification number: C07D211/46 ,  A61K31/445 ,  A61K31/452 ,  C07D211/48 ,  C07D211/58 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D453/02 ,  C07D471/08 ,  G01N33/9433

Abstract: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.

公开(公告)号：US20090076026A1

公开(公告)日：2009-03-19

申请号：US12265091

申请日：2008-11-05

Applicant: Yu-Hua JI ,  Craig Husfeld ,  Mathai Mammen ,  YongQi Mu ,  Eric L. Stangeland

Inventor： Yu-Hua JI ,  Craig Husfeld ,  Mathai Mammen ,  YongQi Mu ,  Eric L. Stangeland

IPC: A61K31/496 ,  C07D401/02 ,  C07D211/32 ,  A61K31/4545 ,  A61K31/445 ,  A61P9/00 ,  A61P11/06 ,  A61K31/454 ,  C07D211/36 ,  C07D211/56

CPC classification number: C07D211/58 ,  C07D211/46 ,  C07D211/62 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D487/08 ,  C07D487/10

Abstract: The invention provides compounds of formula I: wherein a, b, c, d, f, W, Q, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Abstract translation: 本发明提供式I化合物：其中a，b，c，d，f，W，Q，Y，R 1，R 2和R 3如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

公开(公告)号：US07491736B2

公开(公告)日：2009-02-17

申请号：US11880007

申请日：2007-07-19

Applicant: Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Craig Husfeld ,  Li Li

Inventor： Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Craig Husfeld ,  Li Li

IPC: A61K31/445 ,  C07D421/00

CPC classification number: C07D211/62 ,  A61K9/124 ,  A61K9/1623 ,  A61K9/1652 ,  A61K31/4545 ,  A61K45/06 ,  C07D401/12

Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Abstract translation: 本发明提供式I化合物：其中a，b，c，d，m，n，p，s，t，W，Ar1，R1，R2，R3，R4，R6，R7和R8如 规范。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

公开(公告)号：US20090018165A1

公开(公告)日：2009-01-15

申请号：US11879835

申请日：2007-07-19

Applicant: Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Craig Husfeld ,  Li Li

Inventor： Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Craig Husfeld ,  Li Li

IPC: A61K31/4545 ,  C07D211/06 ,  A61P11/00 ,  A61P11/08

CPC classification number: C07D211/62 ,  A61K9/124 ,  A61K9/1623 ,  A61K9/1652 ,  A61K31/4545 ,  A61K45/06 ,  C07D401/12

Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

公开(公告)号：US20080097105A1

公开(公告)日：2008-04-24

申请号：US12001362

申请日：2007-12-11

Applicant: Mathai Mammen ,  Sarah Dunham

Inventor： Mathai Mammen ,  Sarah Dunham

IPC: C07D417/02

CPC classification number: C07D417/12 ,  A61K31/439 ,  A61K31/445 ,  A61K31/4545 ,  C07D277/68

Abstract: The invention is directed to compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7a, R7b, W, G1, G2, a, b, c, d and m are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

Abstract translation: 本发明涉及式I化合物：其中R 1，R 2，R 3，R 4， R 5，R 6，R 7a，R 7b，W，G 1， A，B，C，D和m如说明书中所定义，或其药学上可接受的盐或溶剂合物或立体异构体。 本发明还涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。

公开(公告)号：US20080095708A1

公开(公告)日：2008-04-24

申请号：US11974318

申请日：2007-10-12

Applicant: Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Craig Husfeld ,  Li Li

Inventor： Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Craig Husfeld ,  Li Li

IPC: A61K49/00 ,  A61K31/454 ,  G01N33/53 ,  A61K31/4545

CPC classification number: C07D211/62 ,  A61K9/124 ,  A61K9/1623 ,  A61K9/1652 ,  A61K31/4545 ,  A61K45/06 ,  C07D401/12

Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Abstract translation: 本发明提供式I化合物：其中a，b，c，d，m，n，p，s，t，W，Ar 1，R 1，R R 2，R 3，R 4，R 6，R 7和/或R 4， R 8如本说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

公开(公告)号：US07317102B2

公开(公告)日：2008-01-08

申请号：US10813745

申请日：2004-03-31

Applicant: Mathai Mammen ,  Adam Hughes

Inventor： Mathai Mammen ,  Adam Hughes

IPC: C07D215/12 ,  C07D215/16

CPC classification number: C07D401/12 ,  C07D207/04 ,  C07D207/09 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14

Abstract: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, Ar1, Ar2, E, a, b, c and z are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The compounds of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such compounds are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.

Abstract translation: 本发明提供了式I化合物：其中R 1，R 2，R 3，R 4，R 4， R 5，R 6，R 7，Ar 1，Ar 2，E 2， ，a，b，c和z如说明书中所定义，或其药学上可接受的盐或溶剂合物或立体异构体。 本发明的化合物具有β2/2肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性，因此，这些化合物可用于治疗肺部疾病，如慢性阻塞性肺疾病和哮喘。

公开(公告)号：US20070293461A1

公开(公告)日：2007-12-20

申请号：US11879829

申请日：2007-07-19

Applicant: Mathai Mammen ,  Yu-Hua Ji ,  Yong-Qi Mu ,  Eric Stangeland ,  Aaron Kushner ,  Craig Husfeld

Inventor： Mathai Mammen ,  Yu-Hua Ji ,  Yong-Qi Mu ,  Eric Stangeland ,  Aaron Kushner ,  Craig Husfeld

IPC: A61K31/56 ,  A61K31/45 ,  A61P11/08 ,  A61P9/00 ,  C07D211/06

CPC classification number: C07D211/62 ,  C07D211/60

Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Abstract translation: 本发明提供式I化合物：其中a，b，c，d，m，n，p，r，R 1，R 2，R 3 R 4，R 5，R 5，R 6，R 7和W定义如上所述。 在规范中。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。