公开(公告)号：US5100877A

公开(公告)日：1992-03-31

申请号：US282398

申请日：1988-12-05

申请人： Fumio Mori ,  Masafumi Okada ,  Shuji Miki ,  Iwao Ebashi ,  Takashi Nishida ,  Kouichiro Kawai ,  Tazuko Tashiro ,  Shigeru Tsukagoshi

发明人： Fumio Mori ,  Masafumi Okada ,  Shuji Miki ,  Iwao Ebashi ,  Takashi Nishida ,  Kouichiro Kawai ,  Tazuko Tashiro ,  Shigeru Tsukagoshi

IPC分类号： C08B37/00

CPC分类号： C08B37/0018 ,  Y10S514/908

摘要： A pullulan derivative having one or more active sites resulting from introduction of sulfuric acid, phosphoric acid, a sulfonic acid or a carboxylic acid, wherein one hydrogen atom of the group of the formula ##STR1## occurring at said active sites is partly substituted by a group of the general formula ##STR2## wherein L.sup.1 and L.sup.2 each independently is amine or a unidentate ligand amine or combinedly represent a bidentate ligand amine and Y is an anionic ligand, and/or two hydrogen atoms of the group ##STR3## groups bound to one and the same carbon atom or to two neighboring carbon atoms as occurring at said active sites are, each independently, partly substituted by a group of the general formula ##STR4## wherein L.sup.1 and L.sup.2 are as defined above, and a pharmacologically acceptable salt thereof.The above compound has anticancer activity and is useful as anticancer agents.The present invention is concerned with said compound, a process for producing the same and a pharmaceutical use thereof.

摘要翻译： 具有由引入硫酸，磷酸，磺酸或羧酸产生的一个或多个活性位点的支链淀粉衍生物，其中在所述活性位点发生的式“IMAGE”基团的一个氢原子部分被 通式为“IMAGE”的基团，其中L1和L2各自独立地为胺或一元配体胺，或者组合表示二齿配体胺，Y为阴离子配位体，和/或组中的两个氢原子结合至 在所述活性位点处发生的同一个碳原子或两个相邻的碳原子各自独立地部分地被通式“IMAGE”所示的基团取代，其中L1和L2如上所定义，及其药理学上可接受的盐 。 上述化合物具有抗癌活性，可用作抗癌剂。 本发明涉及所述化合物，其制备方法及其药物用途。

公开(公告)号：US3959009A

公开(公告)日：1976-05-25

申请号：US550028

申请日：1975-02-14

申请人： Koso Kato ,  Tatsuo Nomura

发明人： Koso Kato ,  Tatsuo Nomura

IPC分类号： C12P19/12 ,  C08B37/00 ,  C12D13/04 ,  C13L3/00

CPC分类号： C08B37/0018 ,  Y10S435/911

摘要： A continuous method for purifying pullulan characterized in that two or more tanks containing aqueous solvent solutions of different concentrations are installed in a series wherein the solvent concentrations are always kept lower than the one following, and comprising successively ejecting an aqueous pullulan solution into the first tank to form a mixture wherein pullulan particles are suspended keeping the aqueous solvent solution constantly at a higher concentration than that necessary for precipitating the pullulan particles, separating the pullulan particle suspension from the mixture, transferring the separated pullulan particle suspension into an adjoining tank, repeating such steps, at least once, to dehydrate the pullulan particles and then successively recovering the dehydrated pullulan in a power form from the last tank.

摘要翻译： 一种用于纯化支链淀粉的连续方法，其特征在于，将两种或更多种含有不同浓度的水性溶剂溶液的罐安装在其中溶剂浓度始终保持低于随后的溶剂浓度的系列中，并且包括将支链淀粉溶液依次喷射到第一罐 以形成一种混合物，其中将支链淀粉颗粒悬浮以保持水溶剂溶液的持续时间高于沉淀支链淀粉颗粒所需的浓度，将支链淀粉颗粒悬浮液与混合物分离，将分离的支链淀粉颗粒悬浮液转移到相邻的罐中， 步骤，至少一次，使支链淀粉颗粒脱水，然后从最后一个罐中以电力形式连续回收脱水的支链淀粉。

公开(公告)号：US3931146A

公开(公告)日：1976-01-06

申请号：US473749

申请日：1974-05-28

申请人： Koso Kato ,  Makoto Shiosaka

发明人： Koso Kato ,  Makoto Shiosaka

IPC分类号： A23G3/50 ,  A21D2/00 ,  A23L7/109 ,  A23L29/269 ,  C08B37/00 ,  C12P19/10 ,  C07G3/00

CPC分类号： C08B37/0018 ,  A23L29/274 ,  C12P19/10

摘要： Hydrogenated pullulan is produced by the reaction of an aqueous solution of pullulan with hydrogen gas under pressure in the presence of suitable catalysts until the reducing property of the solution disappears. The hydrogenated pullulan is much more resistant to heat than pullulan and its aqueous solution hardly loses viscosity and is not colored under heat treatment. The hydrogenated pullulan is much less absorbable by the intestinal walls than pullulan so as to reduce more effectively the caloric value of foods when it is mixed with foods. Shaped bodies such as films, sheets, plates, capsules, containers, coatings and fibers are readily prepared in a conventional manner. The films are practically impervious to atmospheric oxygen and suitable as packaging material.

摘要翻译： 氢化支链淀粉通过在合适的催化剂存在下在压力下由支链淀粉水溶液与氢气反应而生成，直到溶液的还原性质消失。 氢化支链淀粉比支链淀粉更耐热，其水溶液几乎不失去粘度，并且在热处理下不着色。 与支链淀粉相比，氢化支链淀粉比肠壁吸收得少得多，以便与食物混合时更有效地降低食物的热值。 诸如薄膜，片材，板，胶囊，容器，涂层和纤维的成形体容易以常规方式制备。 这些薄膜实际上不受大气氧气的影响，适合作为包装材料使用。

公开(公告)号：US137213A

公开(公告)日：1873-03-25

申请号：US137213D

CPC分类号： B01J20/26 ,  C08B37/0018