公开(公告)号：US20210023179A1

公开(公告)日：2021-01-28

申请号：US16998349

申请日：2020-08-20

Applicant: Ventria Bioscience Inc. ,  The Regents of the University of Colorado, a body corporate

Inventor： Christopher MacManus ,  Colm Collins ,  Edwin De Zoeten

IPC: A61K38/40 ,  A61P37/02 ,  A61P1/00 ,  A61P29/00

Abstract: Provided herein are improved compositions comprising plant-derived recombinant human lactoferrin (rhLF) and treatment methods for modulating an immune response to improve the balance between anti-inflammatory cytokine producing cells and pro-inflammatory cells, and skew naïve T cells toward a pro-regulatory phenotype.

公开(公告)号：US10881322B2

公开(公告)日：2021-01-05

申请号：US15687358

申请日：2017-08-25

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Tor Wager ,  Marina Lopez-Sola

IPC: A61B5/055 ,  A61B5/00 ,  G01R33/48

Abstract: Described herein are novel fMRI-based neurologic signatures that predict fibromyalgia (FM), clinical severity, and treatment outcomes. Further described are methods for diagnosing FM and for predicting or evaluating efficacy of a treatment of FM based on the neurologic signature.

公开(公告)号：US20200377561A1

公开(公告)日：2020-12-03

申请号：US16616372

申请日：2018-05-23

Applicant: Robert S. HODGES ,  Ziqing JIANG ,  Lajos GERA ,  Colin T. MANT ,  THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate

Inventor： Robert S. HODGES ,  Ziqing JIANG ,  Lajos GERA ,  Colin T. MANT

IPC: C07K14/46 ,  A61K38/00 ,  A61P31/04

Abstract: Antimicrobial agents, including antimicrobial peptides (AMPs) and uses thereof. Compositions and methods of using dermaseptin-type and piscidin-type antimicrobial peptide variants that demonstrate activity and improved therapeutic indices against microbial pathogens. The peptide compositions demonstrate the ability to not only maintain or improve antimicrobial activity against bacterial pathogens including Gram-negative microorganisms Acinetobacter baumannii and Pseudomonas aeruginosa, but also significantly decrease hemolytic activity against human red blood cells. Specificity determinants within the AMPs change selectivity from broad spectrum antimicrobial activity to Gram-negative selectivity.

公开(公告)号：US10829834B2

公开(公告)日：2020-11-10

申请号：US15741159

申请日：2016-03-04

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Alan W. Weimer ,  Aaron W. Palumbo ,  Illias Hischier ,  Arto J. Groehn ,  Boris A. Chubukov ,  Scott C. Rowe ,  Richard Fisher

IPC: C22B5/10 ,  C22B5/16 ,  C22B9/04 ,  C22B21/02 ,  C22B26/22

Abstract: Systems and methods for recovering material from a gas phase are provided. Exemplary systems include a moving bed of particles onto which material can be deposited. The systems can operate in a continuous or semi-continuous mode.

公开(公告)号：US20200332302A1

公开(公告)日：2020-10-22

申请号：US16959252

申请日：2018-12-30

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate

Inventor： Xiao-Jing WANG

IPC: C12N15/62 ,  C12N15/79 ,  C07K14/495 ,  A61P37/02 ,  A61P17/02

Abstract: The present technology provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of truncated Smad7 compositions delivered locally or systemically to a site of inflammation and/or tissue damage is described. Other specific embodiments concern treatment or prevention of side effects caused by radiation and/or chemotherapy, including but not limited to oral and gastric mucositis. Also provided are codon-optimized nucleic acids encoding for Smad7 fusion proteins.

公开(公告)号：US20200330660A1

公开(公告)日：2020-10-22

申请号：US16796826

申请日：2020-02-20

Applicant: Cor Medical Ventures LLC ,  The Regents of the University of Colorado, a body corporate

Inventor： Vikas Patel ,  Christopher Kleck ,  Brian Bowman ,  Tina John ,  Jude Paganelli

IPC: A61M1/00 ,  A61F13/02

Abstract: A device and method for treatment of post-operative surgical site wounds. Device includes an elongated hollow shaft that spans from the wound closure to the deep wound area, the internal end abutting a wound dressing and the external end connecting to a device that can provide negative-pressure suction and irrigation. Device providing one or more of irrigation, suction, and/or local antibiotic delivery to deep infections through a closed-wound. The method for removal includes narrowing a removal element relative to the long axis, collapsing the wound dressing; removing the wound dressing through the elongated shaft; and removing the device through a closed wound, avoiding a second removal surgery.

公开(公告)号：US10791731B2

公开(公告)日：2020-10-06

申请号：US15580980

申请日：2016-06-08

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate

Inventor： Michael P. Chapman ,  Ernest Moore

IPC: A01N1/02 ,  A61M1/02 ,  A61K35/16

Abstract: Systems for controlled freezing, storing and thawing a biological material in a bag and supporting apparatus. The systems are adapted to receive the biological material therein for freezing, storing, transporting and rapid thawing immediately prior to administration to a patient in need of the biological material.

公开(公告)号：US10786289B2

公开(公告)日：2020-09-29

申请号：US15325822

申请日：2015-07-16

Applicant: The Regents of the University of Colorado, a Body Corporate

Inventor： Vikas Patel ,  Jay Nanninga

IPC: A61B17/80

Abstract: A plate including elements for receiving threads of a fastener element such that the fastener element may be positioned close, if not flush, to a surface of the plate allowing placement of the assembly much closer to a joint than previous known methods and without interfering with the function of a joint.

公开(公告)号：US20200299762A1

公开(公告)日：2020-09-24

申请号：US16211817

申请日：2018-12-06

Applicant: The Regents of the University of Colorado, a Body Corporate

Inventor： Prashant Nagpal ,  Manjunatha Sagar Dodderi

IPC: C12Q1/6869 ,  G01N21/65

Abstract: Disclosed herein is a multiplexed design with three-dimensional plasmonic nanofocusing and confinement of light, demonstration of reproducible and robust single-molecule optical fingerprints using two complementary vibrational spectroscopy techniques (infrared and Raman spectroscopy), identification of respective vibrational modes which uniquely fingerprint the biomolecular species, and facile differentiation of respective fingerprints in DNA mixtures, as well as epigenetic modifications. While the nanometer scale mode volumes still prevent single letter identification of DNA sequence, we show an alternative method for identifying A, T, G, C DNA nucleotides in “k-mers” using sequences of these blocks as a unique and high-throughput alternative to single letter sequences (similar to binary and hexadecimal systems). Furthermore, additivity shown in single-molecule DNA mixtures and robust optical signatures can also be used in a raster-type step scan to identify single letter sequences. These results can pave the way for the development of a novel, high-throughput block optical sequencing (BOS) method.

公开(公告)号：US20200299727A1

公开(公告)日：2020-09-24

申请号：US16827454

申请日：2020-03-23

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Kunhua Song ,  Congwu Chi ,  Yingqiong Cao

IPC: C12N15/86 ,  C12N9/22 ,  C12N15/90

Abstract: The disclosed technology includes methods of treating Danon disease, for example correcting genetic mutations in the LAMP-2 gene and ameliorating at least one Danon disease phenotype, for example defective LAMP-2B-mediated autophagy. In some implementations, the disclosed methods include editing a mutated form of the LAMP-2 gene in a patient in need thereof. In some implementations, editing the mutated form of the LAMP-2 gene may include use of a CRISPR editing technique targeted to the mutated form of the LAMP-2 gene. As a result, mutated LAMP-2 proteins in mammalian subjects may be restored in at least some of the affected cells, for example cardiomyocytes.