公开(公告)号：US20090128346A1

公开(公告)日：2009-05-21

申请号：US11943133

申请日：2007-11-20

申请人： Hong Zhao ,  Christian Flowers ,  Dean Thorson

发明人： Hong Zhao ,  Christian Flowers ,  Dean Thorson

IPC分类号： G08B21/00

CPC分类号： G08B21/24 ,  H02J7/0021 ,  H02J2007/0001 ,  H04M1/6075

摘要： Disclosed are devices and methods of electronic devices for activating an alarm when it is detected that an applied charging voltage has dropped below a threshold value. An electronic device is configured to detect the type of charger, for example, a bicycle charger or motorcycle charger, connected to the electronic device according to a charger attribute. The electronic device may further detect when the applied charging voltage has decreased below the predetermined threshold value. When the device is detected to be connected to a particular type of charger, and it is detected that the applied charging voltage has decreased below the threshold value, the alarm may be activated after a predetermined time. In this way, a user of a bicycle charger or other vehicle charger can be reminded to remove the electronic device from the charging cradle of the vehicle, helping to avoid loss or theft of the device.

摘要翻译： 公开了当检测到施加的充电电压已经降到阈值以下时用于激活报警的电子装置的装置和方法。 电子设备被配置为根据充电器属性检测连接到电子设备的充电器的类型，例如自行车充电器或摩托车充电器。 电子设备还可以检测施加的充电电压何时降低到预定阈值以下。 当检测到设备连接到特定类型的充电器，并且检测到所施加的充电电压已经降低到阈值以下时，可以在预定时间之后激活警报。 以这种方式，可以提醒自行车充电器或其他车辆充电器的使用者从车辆的充电座移除电子设备，有助于避免设备的丢失或被盗。

公开(公告)号：US20080249260A1

公开(公告)日：2008-10-09

申请号：US11508507

申请日：2006-08-23

申请人： Hong Zhao ,  Belen Rubio ,  Jing Xia

发明人： Hong Zhao ,  Belen Rubio ,  Jing Xia

IPC分类号： C08F8/04

CPC分类号： C08G65/33303 ,  A61K47/60

摘要： The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal azide with a phosphine-based reducing agent such as triphenylphosphine or an alkali metal borohydride reducing agent such as sodium borohydride in a solvent to reflux. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.

摘要翻译： 本发明涉及制备高纯度的含有末端胺的聚环氧烷的线性聚合物的方法。 一种优选的方法包括在溶剂中使含有末端叠氮化物的聚乙二醇与膦类还原剂如三苯基膦或碱金属硼氢化物还原剂如硼氢化钠的聚环氧烷反应进行反应。 得到的聚合物胺具有足够的纯度，因此避免了医药级聚合物所需的昂贵且耗时的纯化步骤。

公开(公告)号：US20070078257A1

公开(公告)日：2007-04-05

申请号：US11242656

申请日：2005-10-04

申请人： Hong Zhao ,  Belen Rubio

发明人： Hong Zhao ,  Belen Rubio

IPC分类号： C08G73/00

CPC分类号： C08G65/33303 ,  C08G65/3348

摘要： The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal tosylate with a protected amine salt to form a polymer containing a terminal protected amine and thereafter deprotecting the polymer containing the terminal protected amine to form the polymer having a terminal amine. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.

摘要翻译： 本发明涉及制备高纯度的含有末端胺的聚环氧烷的线性聚合物的方法。 一种优选的方法包括使聚环氧烷如含有甲苯磺酸末端的聚乙二醇与受保护的胺盐反应形成含有末端保护的胺的聚合物，然后使包含末端被保护的胺的聚合物脱保护，形成具有末端胺的聚合物。 得到的聚合物胺具有足够的纯度，因此避免了医药级聚合物所需的昂贵且耗时的纯化步骤。

公开(公告)号：US07065511B2

公开(公告)日：2006-06-20

申请号：US10045668

申请日：2001-10-24

申请人： Hong Zhao ,  Guillermo Sentoni ,  John P. Guiver

发明人： Hong Zhao ,  Guillermo Sentoni ,  John P. Guiver

IPC分类号： G06N5/00

CPC分类号： G05B13/048 ,  G05B17/02

摘要： A non-linear dynamic predictive device (60) is disclosed which operates either in a configuration mode or in one of three runtime modes: prediction mode, horizon mode, or reverse horizon mode. An external device controller (50) sets the mode and determines the data source and the frequency of data. In the forward modes (prediction and horizon), the data are passed to a series of preprocessing units (20) which convert each input variable (18) from engineering units to normalized units. Each preprocessing unit feeds a delay unit (22) that time-aligns the input to take into account dead time effects. The output of each delay unit is passed to a dynamic filter unit (24). Each dynamic filter unit internally utilizes one or more feedback paths that provide representations of the dynamic information in the process. The outputs (28) of the dynamic filter units are passed to a non-linear approximator (26) which outputs a value in normalized units. The output of the approximator is passed to a post-processing unit (32) that converts the output to engineering units. This output represents a prediction of the output of the modeled process. In reverse horizon mode, data is passed through the device in a reverse flow to produce a set of outputs (64) at the input of the predictive device. These are returned to the device controller through path (66). The purpose of the reverse horizon mode is to provide information for process control and optimization. The predictive device approximates a large class of non-linear dynamic processes. The structure of the predictive device allows it to be incorporated into a practical multivariable non-linear Model Predictive Control scheme, or used to estimate process properties.

摘要翻译： 公开了一种非线性动态预测装置（60），其以配置模式或三种运行时模式之一运行：预测模式，水平模式或反向水平模式。 外部设备控制器（50）设置模式并确定数据源和数据频率。 在正向模式（预测和水平）中，数据被传递到一系列预处理单元（20），其将每个输入变量（18）从工程单元转换成归一化单元。 每个预处理单元馈送延迟单元（22），其对输入进行时间对准以考虑死区时间效应。 每个延迟单元的输出被传递到动态滤波器单元（24）。 每个动态滤波器单元在内部利用一个或多个反馈路径来提供该过程中动态信息的表示。 动态滤波器单元的输出（28）被传递到以归一化单位输出值的非线性近似器（26）。 近似器的输出被传递到将输出转换为工程单位的后处理单元（32）。 该输出表示对建模过程的输出的预测。 在反向水平模式中，数据以反向流程通过设备，以在预测设备的输入处产生一组输出（64）。 这些通过路径（66）返回到设备控制器。 反向水平模式的目的是为过程控制和优化提供信息。 预测装置近似于大类非线性动态过程。 预测装置的结构允许将其结合到实用的多变量非线性模型预测控制方案中，或用于估计过程特性。

公开(公告)号：US06824766B2

公开(公告)日：2004-11-30

申请号：US09888072

申请日：2001-06-22

申请人： Richard B. Greenwald ,  Hong Zhao

发明人： Richard B. Greenwald ,  Hong Zhao

IPC分类号： A61K31785

CPC分类号： A61K47/60

摘要： The present invention includes polymeric transport systems corresponding to the formula: wherein: R31 is a linear or branched polymer residue; Y10 and Y11 are independently O, S, or NR40; X2 is O, S or NR41; R32-35, R37-41, R50 and R51 are independently selected among hydrogen, C1-6 alkyls, C3-12 branched alkyls, C3-8 cycloalkyls, C1-6 substituted alkyls, C3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C1-6 heteroalkyls and substituted C1-6 heteroalkyls; a, b and e are each independently selected positive integers; L is an amino acid residue or a bifunctional linker; X3 is wherein Y12 and Y13 are independently O, S, or NR41; Z is a bond, a moiety that is actively transported into a target cell, a hydrophobic moiety or combinations thereof; D1 and D2 are OH, a residue of a hydroxyl, a residue of an amine-containing moiety or a leaving group; and y1 and y2 are independently selected positive integers.

摘要翻译： 本发明包括对应于下式的聚合物输送系统：其中：R 31是直链或支链聚合物残基; Y10和Y11独立地为O，S或NR40; X2是O，S或NR41; R32-35，R37-41，R50和R51独立地选自氢，C1-6烷基，C3-12支链烷基，C3-8环烷基，C1-6取代的烷基，C3-8取代的环烷基，芳基，取代的芳基， 芳烷基，C 1-6杂烷基和取代的C 1-6杂烷基; a，b和e各自独立选择正整数; L是氨基酸残基或双功能连接体; X3中Y12和Y13独立地为O，S或NR41; Z是一个键，一个主要被运送到靶细胞中的部分，一个疏水部分或它们的组合; D1和D2是OH，羟基的残基，含胺部分的残基或离去基团; y1和y2是独立选择的正整数。

公开(公告)号：US06649778B1

公开(公告)日：2003-11-18

申请号：US10252024

申请日：2002-09-20

申请人： Hong Zhao ,  Richard B. Greenwald

发明人： Hong Zhao ,  Richard B. Greenwald

IPC分类号： C07D30514

CPC分类号： C07D409/12 ,  C07D305/14

摘要： Methods of preparing amino acid-substituted taxanes such as: using selected blocked amino acids are disclosed. After coupling of the blocked amino acid to the taxane, deprotection is carried out with about an equimolar amount of a secondary amine thus substantially avoiding base-catalyzed hydrolysis of amino acid from the taxane. The preferred amino acid-taxanes are useful as intermediates in the production of polymer conjugated therapeutic compositions or as part of pharmaceutically acceptable formulations.

摘要翻译： 公开了制备氨基酸取代的紫杉烷的方法，例如：使用选择的封闭的氨基酸。 在封闭的氨基酸与紫杉烷偶联之后，用约等摩尔量的仲胺进行脱保护，因此基本上避免了氨基酸从紫杉烷中的碱催化的水解。 优选的氨基酸 - 紫杉烷可用作生产聚合物缀合的治疗组合物或作为药学上可接受的制剂的一部分的中间体。

公开(公告)号：US06608076B1

公开(公告)日：2003-08-19

申请号：US10147168

申请日：2002-05-16

申请人： Richard B. Greenwald ,  Hong Zhao

发明人： Richard B. Greenwald ,  Hong Zhao

IPC分类号： A61K314745

CPC分类号： C07D471/14 ,  A61K47/55 ,  A61K47/60

摘要： Polymeric conjugates of camptothecin derivatives having increased circulating half-lives are disclosed. In preferred aspects, the E ring lactone of the camptothecin derivative is opened and functionalized to allow attachment of a polymer such as PEG in the 17- or 20-position thereof. A representative example of such compounds is Methods of preparing and using the same are also disclosed.

摘要翻译： 公开了具有增加的循环半衰期的喜树碱衍生物的聚合物共轭物。 在优选的方面，喜树碱衍生物的E环内酯被打开并官能化以允许聚合物如PEG在其17或20位的附着。 这些化合物的代表性实例也是公开了制备和使用它们的方法。

公开(公告)号：US06331582B1

公开(公告)日：2001-12-18

申请号：US09541644

申请日：2000-04-03

申请人： Augustin T. Chen ,  Paul E. Kestyn ,  Hong Zhao

发明人： Augustin T. Chen ,  Paul E. Kestyn ,  Hong Zhao

IPC分类号： C08K311

CPC分类号： C09D167/00 ,  C09D201/00 ,  C08L29/00

摘要： A liquid surface coating composition which exhibits low gloss after curing or drying comprises binder resin other than polyvinyl acetal, pigment colorant and a gloss-reducing amount of matting agent consisting essentially of polyvinyl acetal containing acetal groups derived from one or more aliphatic or aromatic aldehydes having 1 to 10 carbon atoms, preferably polyvinyl butyral of weight average molecular weight between 10,000 to 500,000 Daltons.

摘要翻译： 在固化或干燥后显示低光泽度的液体表面涂料组合物包括除聚乙烯醇缩醛之外的粘合剂树脂，颜料着色剂和减光量的消光剂，其基本上由含有一个或多个脂族或芳族醛的缩醛基组成的聚乙烯醇缩醛组成， 1至10个碳原子，优选重均分子量在10,000至500,000道尔顿之间的聚乙烯醇缩丁醛。

公开(公告)号：US11996549B2

公开(公告)日：2024-05-28

申请号：US17120209

申请日：2020-12-13

申请人： Hong Zhao

发明人： Hong Zhao

IPC分类号： H01M4/36 ,  C23C16/02 ,  C23C16/26 ,  H01M4/04 ,  H01M4/48 ,  H01M4/587 ,  H01M10/0525 ,  H01M4/02

CPC分类号： H01M4/366 ,  C23C16/0209 ,  C23C16/26 ,  H01M4/0428 ,  H01M4/483 ,  H01M4/587 ,  H01M10/0525 ,  H01M2004/027 ,  H01M2220/20

摘要： A method for preparing a silicon monoxide composite material includes: a first stage: introducing a protective gas into a vapor deposition oven, and pre-heating a silicon monoxide raw material, such that a part of the silicon monoxide raw material is subjected to a disproportionation reaction; a second stage: continuously introducing the protective gas and introducing a carbon source gas, and subjecting the pre-heated silicon monoxide raw material to a chemical vapor deposition to form carbon nanotubes on a surface of silicon monoxide; and a third stage: after a predetermined time period, stopping introducing the carbon source gas, and stopping introducing the protective gas until the vapor deposition oven is cooled to room temperature, to prepare the silicon monoxide composite material. During the preparation process, no extra catalyst needs to be added, a product of the previous disproportionation reaction may act as a catalyst for the growth of the carbon nanotubes.

公开(公告)号：US09708371B2

公开(公告)日：2017-07-18

申请号：US14239178

申请日：2012-08-17

申请人： Marco Kessler ,  Angelika Fretzen ,  Hong Zhao ,  Robert Solinga ,  Vladimir Volchenok

发明人： Marco Kessler ,  Angelika Fretzen ,  Hong Zhao ,  Robert Solinga ,  Vladimir Volchenok

IPC分类号： C07K7/08 ,  C11D3/34 ,  C07K7/54 ,  C07K5/02 ,  A61K38/10 ,  A61K38/12 ,  A61K45/06

CPC分类号： C07K7/08 ,  A61K38/10 ,  A61K38/12 ,  A61K45/06 ,  C07K5/02 ,  C07K7/54 ,  C11D3/3436 ,  G01N2800/065 ,  Y02A50/414

摘要： The present invention features peptides, compositions, and related methods for treating gastrointestinal disorders and conditions, including but not limited to, irritable bowel syndrome (IBS), gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia, visceral pain, gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), disorders and conditions associated with constipation, and other conditions and disorders are described herein, using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.