公开(公告)号：US20220033376A1

公开(公告)日：2022-02-03

申请号：US17309712

申请日：2019-12-17

Applicant: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. ,  MEDSHINE DISCOVERY INC.

Inventor： Shuwen DUAN ,  Jianyu LU ,  Lihong HU ,  Charles Z. DING ,  Guoping HU ,  Jian LI ,  Shuhui CHEN

IPC: C07D401/06 ,  C07D401/14 ,  C07D409/14 ,  C07D209/20 ,  A61P35/00

Abstract: Provided is an indole compound. In particular, disclosed are a compound represented by formula (II) or an isomer or pharmaceutically acceptable salt thereof and a use of the same as an estrogen receptor antagonist in preparing a drug for treating estrogen receptor-positive breast cancer.

公开(公告)号：US20210395252A1

公开(公告)日：2021-12-23

申请号：US17281479

申请日：2019-09-27

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Xiangyu FU ,  Charles Z. DING ,  Lihong HU ,  Jianyu LU ,  Wen JIANG ,  Jian LI ,  Shuhui CHEN

IPC: C07D471/10 ,  A61P35/02

Abstract: Disclosed in the present invention is a novel compound as FLT3 and AXL inhibitors. Specifically, disclosed are a compound represented by formula (I) and a pharmacologically acceptable salt thereof. (I)

公开(公告)号：US11198686B2

公开(公告)日：2021-12-14

申请号：US16755386

申请日：2018-10-12

Applicant: GUANGZHOU JOYO PHARMATECH CO., LTD. ,  SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO, LTD. ,  MEDSHINE DISCOVERY INC.

Inventor： Lei Zhang ,  Bin Chen ,  Yangguang Zhao ,  Jian Li ,  Shuhui Chen

IPC: C07D409/14 ,  A61P11/00 ,  A61K31/4436

Abstract: A crystal form of a compound 1 and a method for preparing the same, further comprising an application of the crystal form in the preparation of a drug for treating diseases associated with fibrosis.

公开(公告)号：US20210323979A1

公开(公告)日：2021-10-21

申请号：US17053076

申请日：2019-05-08

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Kevin X CHEN ,  Fen JIANG ,  Xinde CHEN ,  Li ZHANG ,  Zhaoguo CHEN ,  Yanxin YU ,  Kai ZHOU ,  Boyu HU ,  Cheng XIE ,  Shuhui CHEN

IPC: C07D519/00 ,  A61P35/00

Abstract: The present invention relates to a group of pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and an application thereof in the preparation of a drug that serves as an HER2 inhibitor. Specifically, the present invention relates to a compound represented by formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11117899B2

公开(公告)日：2021-09-14

申请号：US16500901

申请日：2018-04-08

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Kevin X Chen ,  Yanxin Yu ,  Xinde Chen ,  Li Zhang ,  Zhaoguo Chen ,  Cheng Xie ,  Xiaofei Wang ,  Linghui Wu ,  Guoping Hu ,  Jian Li ,  Shuhui Chen

IPC: C07D487/04 ,  A61P25/16 ,  A61P35/00

Abstract: Provided are a compound represented by formula (I), an isomer or a pharmaceutically acceptable salt thereof, and an application of the same in preparing a drug for treating a disease related to A2A receptor. The R1, R2, R3, ring A, ring B, n, and m are as defined in the specification.

公开(公告)号：US20210269459A1

公开(公告)日：2021-09-02

申请号：US17254778

申请日：2019-06-25

Applicant: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. ,  MEDSHINE DISCOVERY INC.

Inventor： Yang ZHANG ,  Jianfei WANG ,  Haizhong TAN ,  Jie LI ,  Jian LI ,  Shuhui CHEN

IPC: C07D513/04 ,  C07D519/00

Abstract: Disclosed in the present invention are an IRAK4 inhibitor, and an application thereof in preparation of a drug for treating IRAK4-related diseases. Specifically disclosed are a compound represented by formula (III) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US10995087B2

公开(公告)日：2021-05-04

申请号：US16765922

申请日：2018-11-20

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Jianfei Wang ,  Yang Zhang ,  Wenyuan Zhu ,  Jian Li ,  Shuhui Chen

IPC: C07D409/04

Abstract: Disclosed are a crystal form of a URAT1 inhibitor, and a preparation method therefor.

公开(公告)号：US20210087168A1

公开(公告)日：2021-03-25

申请号：US16967546

申请日：2019-02-02

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Wenyuan QIAN ,  Chundao YANG ,  Guanghai XU ,  Jian LI ,  Shuhui CHEN

IPC: C07D401/14 ,  C07D401/04 ,  C07D417/14 ,  A61P9/12 ,  C07D241/20

Abstract: A compound represented by formula (I) or an isomer or a pharmaceutically acceptable salt thereof. The present invention also relates to an application of the same in preparing a drug for treating a disease related to a PGI2 receptor.

公开(公告)号：US20200231597A1

公开(公告)日：2020-07-23

申请号：US16635916

申请日：2018-07-27

Applicant: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. ,  MEDSHINE DISCOVERY INC.

Inventor： Kevin X CHEN ,  Kai ZHOU ,  Yanxin YU ,  Boyu HU ,  Linghui WU ,  Xiaoyuan CHEN ,  Jiangfeng LIN ,  Haomin CHEN ,  Xiangjian WANG ,  Xiquan ZHANG ,  Xin TIAN ,  Hongjiang XU

IPC: C07D495/04

Abstract: A bicyclic compound acting as a RORγ inhibitor. Provided are a compound of formula (I) or a pharmaceutically acceptable salt thereof, the compound having a structure as represented by formula (I-A) or formula (I-B). The provided compound of formula (I-A) or formula (I-B) or pharmaceutically acceptable salt thereof has good RORγ inhibitory activities, being expected to be used for treating diseases mediated by RORγ receptors in a mammal.

公开(公告)号：US10647710B2

公开(公告)日：2020-05-12

申请号：US16476797

申请日：2018-01-09

Applicant: Medshine Discovery Inc.

Inventor： Haiying He ,  Zhigan Jiang ,  Weihua Shi ,  Jianhua Xia ,  Jian Li ,  Shuhui Chen

IPC: C07D417/12 ,  C07D417/14 ,  C07D277/54 ,  A61P31/22

Abstract: Disclosed in the present invention are a new thiazole compound, particularly a compound represented by formula (I), a pharmaceutical composition thereof and applications thereof in the preparation of drugs for the treatment of diseases related to herpes simplex viruses.