公开(公告)号：US20210380599A1

公开(公告)日：2021-12-09

申请号：US17280538

申请日：2019-09-27

申请人： MEDSHINE DISCOVERY INC.

发明人： Wenyuan QIAN ,  Chundao YANG ,  Guoqiang DAI ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D491/20 ,  A61K31/7048 ,  A61P35/00 ,  C07D471/04 ,  C07D471/20

摘要： Disclosed are a series of quinolino-pyrrolidin-2-one compounds, and application thereof in preparation of drugs for ATM inhibitor-related diseases. The present disclosure specifically relates to a derivative compound represented by formula (I), tautomers thereof or pharmaceutically acceptable compositions thereof.

公开(公告)号：US20230357241A1

公开(公告)日：2023-11-09

申请号：US18246247

申请日：2021-09-24

申请人： MEDSHINE DISCOVERY INC.

发明人： Wenyuan QIAN ,  Xiawei WEI ,  Chundao YANG ,  Guanghai XU ,  Ning JIANG ,  Shuhui CHEN

IPC分类号： C07D471/04 ,  A61P35/00

CPC分类号： C07D471/04 ,  A61P35/00

摘要： A series of 1H-pyrrolo[2,3-c]pyridine compounds and an application thereof are provided. The compounds include those represented by formula (P) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20210107894A1

公开(公告)日：2021-04-15

申请号：US16959706

申请日：2019-01-03

申请人： MEDSHINE DISCOVERY INC.

发明人： Wenyuan QIAN ,  Chundao YANG ,  Guanghai XU ,  Jie LI ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D401/14 ,  A61K9/00

摘要： The present invention relates to a class of isoindolinone derivatives and use thereof in the preparation of a medicament for treating diseases associated with a novel colony stimulating factor 1 receptor (CSF-1R) inhibitor. In particular, the present invention relates to a compound of formula (I) and a pharmaceutically acceptable salt thereof or a stereoisomer thereof.

公开(公告)号：US20210087168A1

公开(公告)日：2021-03-25

申请号：US16967546

申请日：2019-02-02

申请人： MEDSHINE DISCOVERY INC.

发明人： Wenyuan QIAN ,  Chundao YANG ,  Guanghai XU ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D401/14 ,  C07D401/04 ,  C07D417/14 ,  A61P9/12 ,  C07D241/20

摘要： A compound represented by formula (I) or an isomer or a pharmaceutically acceptable salt thereof. The present invention also relates to an application of the same in preparing a drug for treating a disease related to a PGI2 receptor.

公开(公告)号：US20190210975A1

公开(公告)日：2019-07-11

申请号：US16325626

申请日：2017-08-22

申请人： MEDSHINE DISCOVERY INC.

发明人： Yunfu LUO ,  Chundao YANG ,  Maoyi LEI ,  Lanbao SUN ,  Guoping HU ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D235/26 ,  C07D263/58 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D417/10 ,  C07D401/10

摘要： Provided are a phosphodiesterase-4 (PDE4) inhibitor and application thereof in preparation of a medication for treating a disease related to PDE4. Specifically disclosed is a compound as shown in formula (I) and a pharmaceutically acceptable salt thereof.