公开(公告)号：US20230055321A1

公开(公告)日：2023-02-23

申请号：US17778533

申请日：2020-11-20

申请人： MEDSHINE DISCOVERY INC.

发明人： Kevin X CHEN ,  Shanghua XIA ,  Zhaoguo CHEN ,  Zuhao GUO ,  Yanxin YU ,  Kai ZHOU ,  Boyu HU ,  Li ZHANG ,  Fen JIANG ,  Jingjing WANG ,  Guoping HU ,  Jian LI ,  Shuhui CHEN

IPC分类号： A61K31/519 ,  C07D519/00 ,  A61K45/06 ,  A61K31/55

摘要： Provided are a class of DNA-PK inhibitor, and specifically, a compound represented by formula (III) or a pharmaceutically acceptable salt thereof, and use thereof in the preparation of DNA-PK inhibitor-related drugs.

公开(公告)号：US20220281868A1

公开(公告)日：2022-09-08

申请号：US17629117

申请日：2020-07-23

申请人： MEDSHINE DISCOVERY INC.

发明人： Yaxian CAI ,  Xiaobing YAN ,  Zhe CAI ,  Guoping HU ,  Charles Z. DING ,  Kevin X CHEN ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D471/18 ,  A61P7/02

摘要： Macrocyclic derivatives, preparation methods therefor and pharmaceutical compositions comprising said derivatives, and uses thereof as therapeutic agents, especially as factor XIa inhibitors and in drugs for treating and preventing thromboembolisms and other diseases. Specifically disclosed is a compound represented by formula (I), and an isomer and pharmaceutically acceptable salt thereof.

公开(公告)号：US20240109861A1

公开(公告)日：2024-04-04

申请号：US18270317

申请日：2021-12-30

申请人： MEDSHINE DISCOVERY INC.

发明人： Kevin X CHEN ,  Li ZHANG ,  Houze GUI ,  Haoyu ZHANG ,  Huiyu ZHANG ,  Guoping HU ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D401/06 ,  A61P13/12 ,  C07D405/14

CPC分类号： C07D401/06 ,  A61P13/12 ,  C07D405/14

摘要： A series of piperidine-substituted benzoic acid compounds and the use thereof, and specifically disclosed is a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230365558A1

公开(公告)日：2023-11-16

申请号：US18245551

申请日：2021-09-18

申请人： MEDSHINE DISCOVERY INC.

发明人： Kevin X CHEN ,  Zuhao GUO ,  Yanxin YU ,  Boyu HU ,  Jingjing WANG ,  Zhaoguo CHEN ,  Cheng XIE ,  Jian XIONG ,  Yongbo FANG ,  Yingtao LIU ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D471/04 ,  C07D413/12 ,  C07D498/04 ,  C07D498/10 ,  C07D401/12 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D413/12 ,  C07D498/04 ,  C07D498/10 ,  C07D401/12 ,  A61P35/00 ,  C07B2200/13

摘要： A series of tetrahydroisoquinoline derivatives and the crystal forms thereof. Specifically disclosed are a compound as represented by formula (VII), a crystal form thereof, and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230357272A1

公开(公告)日：2023-11-09

申请号：US17906762

申请日：2021-04-06

申请人： MEDSHINE DISCOVERY INC.

发明人： Shuhui CHEN ,  Kevin X CHEN ,  Kai ZHOU ,  Wen JIANG ,  Guoping HU ,  Jian LI

IPC分类号： C07D498/22 ,  C07D471/22 ,  A61P35/00

CPC分类号： C07D498/22 ,  C07D471/22 ,  A61P35/00

摘要： Disclosed is a class of octahydropyrazinodiazanaphthyridine dione compounds, and specifically disclosed are a compound as shown in formula (III) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20220306622A1

公开(公告)日：2022-09-29

申请号：US17594980

申请日：2020-05-06

申请人： MEDSHINE DISCOVERY INC.

发明人： Kevin X CHEN ,  Zhaoguo CHEN ,  Li ZHANG ,  Yanxin YU ,  Kai ZHOU ,  Fen JIANG ,  Shanghua XIA ,  Xiaofei WANG

IPC分类号： C07D471/04

摘要： Disclosed are a salt and a crystal form of an mTORC1/2 dual kinase inhibitor and a preparation method therefor. Also disclosed is use of the salt and crystal form in the preparation of a medicament related to the mTORC1/2 dual kinase inhibitor.

公开(公告)号：US20210323979A1

公开(公告)日：2021-10-21

申请号：US17053076

申请日：2019-05-08

申请人： MEDSHINE DISCOVERY INC.

发明人： Kevin X CHEN ,  Fen JIANG ,  Xinde CHEN ,  Li ZHANG ,  Zhaoguo CHEN ,  Yanxin YU ,  Kai ZHOU ,  Boyu HU ,  Cheng XIE ,  Shuhui CHEN

IPC分类号： C07D519/00 ,  A61P35/00

摘要： The present invention relates to a group of pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and an application thereof in the preparation of a drug that serves as an HER2 inhibitor. Specifically, the present invention relates to a compound represented by formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20200231597A1

公开(公告)日：2020-07-23

申请号：US16635916

申请日：2018-07-27

申请人： CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. ,  MEDSHINE DISCOVERY INC.

发明人： Kevin X CHEN ,  Kai ZHOU ,  Yanxin YU ,  Boyu HU ,  Linghui WU ,  Xiaoyuan CHEN ,  Jiangfeng LIN ,  Haomin CHEN ,  Xiangjian WANG ,  Xiquan ZHANG ,  Xin TIAN ,  Hongjiang XU

IPC分类号： C07D495/04

摘要： A bicyclic compound acting as a RORγ inhibitor. Provided are a compound of formula (I) or a pharmaceutically acceptable salt thereof, the compound having a structure as represented by formula (I-A) or formula (I-B). The provided compound of formula (I-A) or formula (I-B) or pharmaceutically acceptable salt thereof has good RORγ inhibitory activities, being expected to be used for treating diseases mediated by RORγ receptors in a mammal.

公开(公告)号：US20240025921A1

公开(公告)日：2024-01-25

申请号：US18271162

申请日：2022-01-07

申请人： PHAENO THERAPEUTICS CO., LTD. ,  MEDSHINE DISCOVERY INC.

发明人： Kevin X CHEN ,  Jian XIONG ,  Jingjing WANG ,  Guoping HU ,  Jinxin LIU ,  Yu HAN ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D519/00 ,  A61P31/16

CPC分类号： C07D519/00 ,  A61P31/16

摘要： Provided are a class of pyridone multiple-membered ring derivatives and the use thereof. Specifically provided are a compound as represented by formula (VI) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230026616A1

公开(公告)日：2023-01-26

申请号：US17779322

申请日：2020-11-25

申请人： MEDSHINE DISCOVERY INC.

发明人： Kevin X CHEN ,  Shanghua XIA ,  Zhaoguo CHEN ,  Zuhao GUO ,  Yanxin YU ,  Kai ZHOU ,  Boyu HU ,  Li ZHANG ,  Fen JIANG ,  Jingjing WANG ,  Guoping HU ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D519/00 ,  A61P35/00 ,  A61K45/06

摘要： A class of DNA-PK inhibitors, in particular a compound represented by formula (IV) or a pharmaceutically acceptable salt thereof, and an application thereof in the preparation of a drug relating to a DNA-PK inhibitor.