公开(公告)号：US20190104698A1

公开(公告)日：2019-04-11

申请号：US16092034

申请日：2017-04-19

Applicant: KOWA COMPANY, LTD.

Inventor： Naoki MIWA ,  Daisuke NITTA

IPC: A01G31/02

Abstract: [Problem] Provided is a compact cultivation device which has a number of management items (parameters) such as air temperature and CO2 concentration in cultivation space.[Solution] A compact cultivation device 1 according to the present invention is provided with; an air conditioning sensor 6 which detects the air temperature, the CO2 concentration, the humidity, or an air current in a cultivation space A; and a nutrient liquid sensor 8 which detects the temperature, the flow rate, the EC, or the pH of a cultivation liquid B. The compact cultivation device 1 is configured to allow cultivation of a plant V while controlling various management items detected by the sensors 6, 8.

公开(公告)号：US20190030005A1

公开(公告)日：2019-01-31

申请号：US16150514

申请日：2018-10-03

Applicant: KOWA COMPANY, LTD.

Inventor： Toshiaki Takizawa

IPC: A61K31/423 ,  A61K31/202 ,  A61K31/232

Abstract: This invention provides a combination-drug composition and a combination use of pharmaceuticals for preventing and/or treating dyslipidemia states, such as hyper-LDL cholesterolemia, in mammals, including humans. This invention pertains to a drug composition for preventing and/or treating dyslipidemia and the like, said drug composition comprising the following: (R)-2-[3-[[N-(benzoxazole-2-yl)-N-3-(4-methoxyphenoxy)propyl] aminomethyl]phenoxy] butyric acid, a salt thereof, or a solvate of either; and an omega-3 fatty acid or an ester derivative of an ω-3 fatty acid.

公开(公告)号：US20180256595A1

公开(公告)日：2018-09-13

申请号：US15755700

申请日：2016-08-31

Applicant: KOWA COMPANY, LTD.

Inventor： Kenji Kawamata ,  Kazushi Maruo ,  Hideki Suganami

IPC: A61K31/551 ,  A61P27/06

CPC classification number: A61K31/551 ,  A61K45/00 ,  A61P27/06

Abstract: The present invention pertains to a drug available for long-term continuous administration for preventing or treating glaucoma or ocular hypertension, said drug showing no decrease in efficacy during long-term administration and exhibiting a stable ocular hypotensive effect. The present invention pertains to a therapeutic agent for glaucoma or ocular hypertension that is to be continuously administered for a long period of time, said drug comprising an Rho kinase inhibitor, more specifically, to a therapeutic agent comprising an Rho kinase inhibitor for treating glaucoma or ocular hypertension in a patient suffering from glaucoma or ocular hypertension who has been administered with a therapeutic agent comprising the Rho kinase inhibitor for treating glaucoma or ocular hypertension continuously over a definite period of time and needs a further enhanced ocular hypotensive effect.

公开(公告)号：US20180250274A1

公开(公告)日：2018-09-06

申请号：US15903279

申请日：2018-02-23

Applicant: KOWA COMPANY, LTD.

Inventor： Mitsumasa NAKAMURA ,  Satoshi KOJIMA ,  Ryohei TANIGAWA

IPC: A61K31/423 ,  A61K31/575 ,  A61P1/16

CPC classification number: A61K31/423 ,  A61K31/575 ,  A61P1/16

Abstract: The present invention relates to a pharmaceutical composition for the treatment of primary biliary cirrhosis (PBC), in which containing a therapeutically effective amount of (R)-2-[3-[[N-(benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy] butyric acid, a salt thereof, or a solvate thereof.

公开(公告)号：US20180224712A1

公开(公告)日：2018-08-09

申请号：US15504419

申请日：2015-09-07

Applicant: KOWA COMPANY, LTD.

Inventor： Shuichi TOMINAGA ,  Suguru HANZAWA

IPC: G03B9/06 ,  G02B7/02

CPC classification number: G03B9/06 ,  G02B5/005 ,  G02B7/02

Abstract: In the present invention, an edge face of an diaphragm ring (4) has a part (a locked portion) wherein a plurality of depressions (62) are formed and a substantially flat surface wherein no depression (62) is formed, and by a simple operation of operating a link releaser (52) so as to rotate the diaphragm ring (4), it is possible to switch between a click mode and a non-click mode. When taking still images, a diaphragm value can be fixed by using the click mode, and when video is taken, the diaphragm value can be smoothly changed during imaging by using the non-click mode.

公开(公告)号：US20180185337A1

公开(公告)日：2018-07-05

申请号：US15904922

申请日：2018-02-26

Applicant: KOWA COMPANY, LTD.

Inventor： Toshiaki Takizawa ,  Yasunobu Yoshinaka

IPC: A61K31/423 ,  A61K45/06 ,  A61K31/397

CPC classification number: A61K31/423 ,  A61K31/397 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention addresses the problem of providing a pharmaceutical combination composition and drug combinations for the prevention and/or treatment of dyslipidemic conditions such as atherosclerosis, hypercholesterolemia, low HDL blood disease in mammals including humans. A pharmaceutical composition for the prevention and/or treatment of dyslipidemia, etc. which comprises (a) a compound represented by the general formula (1) (in the formula, each symbol is the same as defined in the specification) or a salt thereof or a solvate thereof and (b) a cholesterol absorption inhibitor.

公开(公告)号：US20180124888A1

公开(公告)日：2018-05-03

申请号：US15565768

申请日：2016-03-17

Applicant: KOWA COMPANY, LTD.

Inventor： Yutaka MIZUKUSA ,  Kenichi INOUE ,  Kazuhiro KASHIWAGI ,  Ayafumi TANIJI

IPC: H05B33/08 ,  A01G7/04 ,  H05B37/02

CPC classification number: H05B33/0845 ,  A01G7/045 ,  A01G31/00 ,  H05B37/02 ,  H05B37/0281 ,  Y02P60/146

Abstract: The lighting system for plant cultivation (9) according to the present invention is configured to be capable of switching between an intermittent lighting mode and a continuous lighting mode. The intermittent lighting mode is a mode in which a light source emits light with a lighting cycle comprising a light period of turning on the light source for a predetermined time period and a dark period of turning off the light source for a predetermined time period. The continuous lighting mode is a mode in which the light source continuously emits light. In another aspect, the lighting system for plant cultivation (9) comprises a light source (3), a light source driving unit (2) that drives the light source (3), and a control unit (1) that transmits a pulse signal to the light source driving unit (2). The control unit (1) comprises a first pulse generating unit (11) that generates a first pulse signal (S1) of a predetermined frequency, a second pulse generating unit (12) that generates a second pulse signal (S2) of a frequency different from the predetermined frequency, and a pulse signal selecting unit (13) that selects any one of the first pulse signal (S1) and the second pulse signal (S2) to transmit the selected one to the light source driving unit (2). The light source driving unit (3) includes a frequency determining unit (21) that determines whether the frequency of the pulse signal received from the control unit (1) is the frequency of the first pulse signal (S1) or the frequency of the second pulse signal (S2), a first driving unit (23) that, when receiving the first pulse signal (S1) from the control unit (1), converts the first pulse signal (S1) to a constant current output to drive the light source (3), and a second driving unit (24, 25) that, when receiving the second pulse signal (S2) from the control unit (1), outputs a pulse with an original pulse waveform of the second pulse signal (S2) to drive the light source (3).

公开(公告)号：US20180104096A1

公开(公告)日：2018-04-19

申请号：US15562816

申请日：2016-03-31

Applicant: KOWA COMPANY, LTD.

Inventor： Akiharu Tsuchiya ,  Hodumi Nonaka

IPC: A61F7/03

CPC classification number: A61F7/034 ,  A61F7/03 ,  A61F2007/0222 ,  A61F2007/0223 ,  A61F2007/0257 ,  A61F2007/0258

Abstract: An object of the present invention is to provide an exothermic device which is capable of reaching a high temperature upon use, and capable of sustaining a high temperature state for a prolonged period of time. The present invention provides an exothermic device (1) including: an exothermic agent (5); and a packaging material enclosing the exothermic agent (5). The packaging material is in the form of a flat bag composed of a first surface and a second surface. Each of the first surface and the second surface includes a breathable region (2) and a non-breathable region (3).

公开(公告)号：US09931321B2

公开(公告)日：2018-04-03

申请号：US15399856

申请日：2017-01-06

Applicant: KOWA COMPANY, LTD.

Inventor： Toshiaki Takizawa ,  Yasunobu Yoshinaka

IPC: A61K31/423 ,  A61K31/397 ,  A61K45/06

CPC classification number: A61K31/423 ,  A61K31/397 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention addresses the problem of providing a pharmaceutical combination composition and drug combinations for the prevention and/or treatment of dyslipidemic conditions such as atherosclerosis, hypercholesterolemia, low HDL blood disease in mammals including humans. A pharmaceutical composition for the prevention and/or treatment of dyslipidemia, etc. which comprises (a) a compound represented by the general formula (1) (in the formula, each symbol is the same as defined in the specification) or a salt thereof or a solvate thereof and (b) a cholesterol absorption inhibitor (1).

公开(公告)号：US20170367977A1

公开(公告)日：2017-12-28

申请号：US15535185

申请日：2015-12-11

Applicant: KOWA COMPANY, LTD.

Inventor： Yuuki SUZUKI ,  Isamu SAWAI ,  Hiroshi ODA

IPC: A61K9/08 ,  A61K47/32 ,  A61K47/22 ,  A61K31/352 ,  A61K31/18 ,  A61K31/5377 ,  A61K31/4725 ,  A61K31/435 ,  A61K31/551 ,  A61K45/06

CPC classification number: A61K9/08 ,  A61K9/0048 ,  A61K31/18 ,  A61K31/352 ,  A61K31/353 ,  A61K31/435 ,  A61K31/4704 ,  A61K31/4725 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/06 ,  A61K47/22 ,  A61K47/32 ,  A61K2300/00

Abstract: A technique is provided for reducing the discoloration of an aqueous composition containing a halogenated isoquinoline derivative during high-temperature preservation. An aqueous composition comprising a compound represented by Formula (1): wherein X represents a halogen atom, or a salt thereof, or a solvate of the compound or the salt thereof, and a β blocker.