公开(公告)号：US08219210B2

公开(公告)日：2012-07-10

申请号：US11541837

申请日：2006-10-02

申请人： Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Jiang Ding ,  Yinghong Yu ,  Michael J. Stucky ,  Chris Hartemink

发明人： Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Jiang Ding ,  Yinghong Yu ,  Michael J. Stucky ,  Chris Hartemink

IPC分类号： A61N1/00 ,  A61B5/04

CPC分类号： A61N1/36585 ,  A61B5/02028 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3702 ,  G06F19/00

摘要： A method and apparatus is described for detecting and localizing areas of myocardial infarction or ischemia. By pacing sites in proximity to the infarcted or ischemic region with appropriately timed pacing pulses, the region is pre-excited in a manner that lessens the mechanical stress to which it is subjected, thus reducing the metabolic demand of the region and the stimulus for remodeling.

摘要翻译： 描述了用于检测和定位心肌梗死或缺血区域的方法和装置。 通过以适当的定时起搏脉冲对位于梗塞或缺血区域附近的部位进行起搏，该区域以减轻其受到的机械应力的方式预激发，从而降低该区域的代谢需求和重塑的刺激 。

公开(公告)号：US07974695B2

公开(公告)日：2011-07-05

申请号：US11567933

申请日：2006-12-07

申请人： Yinghong Yu ,  Jiang Ding ,  Julio C. Spinelli ,  Andrew P. Kramer

发明人： Yinghong Yu ,  Jiang Ding ,  Julio C. Spinelli ,  Andrew P. Kramer

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/36564 ,  A61N1/3682

摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as ventricular synchrony or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.

摘要翻译： 用于为诸如心室同步或收缩性（收缩期左心室压力峰值或LV + dp / dt）之间的参数提供最佳血液动力学心脏功能或行程体积（主动脉脉压）的起搏系统，用于计算心室间期延迟 心室起搏脉冲的最佳时机。 该系统为多个血液动力学参数的近似最佳起搏提供了选择。 该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

公开(公告)号：US07957802B2

公开(公告)日：2011-06-07

申请号：US11894082

申请日：2007-08-20

申请人： Abhilash Patangay ,  Jiang Ding ,  Jonathan T. Kwok ,  Barun Maskara ,  Yinghong Yu

发明人： Abhilash Patangay ,  Jiang Ding ,  Jonathan T. Kwok ,  Barun Maskara ,  Yinghong Yu

IPC分类号： A61N1/362

CPC分类号： A61N1/36564 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

摘要： Optimizing cardiac preload based on measured pulmonary artery pressure involves varying, for each repetition of an acute burst protocol, a parameter of pacing applied to a patient's heart during the acute burst protocol. Pulmonary artery pressure is measured during the repetitions of the acute burst protocol. The length of the repetitions is chosen so that the patient's baroreflex system does not adjust to the varied parameter of pacing during the repetitions of the acute burst protocol. An optimum ventricular preload is determined based on the measured pulmonary artery pressure. Pacing therapy is provided using a value of the parameter that is selected based on the determination of optimum ventricular preload.

摘要翻译： 基于测量的肺动脉压优化心脏预压，对于急性突发协议的每个重复，涉及在急性突发协议期间应用于患者心脏的起搏参数的变化。 在急性突发方案的重复期间测量肺动脉压。 选择重复的长度，使得患者的压力反射系统在急性突发协议的重复期间不适应起搏的不同参数。 基于测量的肺动脉压力确定最佳心室预负荷。 使用基于最佳心室预压的确定选择的参数的值提供起搏治疗。

公开(公告)号：US20110106202A1

公开(公告)日：2011-05-05

申请号：US12987700

申请日：2011-01-10

申请人： Jiang Ding ,  Yinghong Yu ,  Bruce H. KenKnight

发明人： Jiang Ding ,  Yinghong Yu ,  Bruce H. KenKnight

IPC分类号： A61N1/368

CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

摘要： A method or system for computing and/or setting optimal cardiac resynchronization pacing parameters as derived from intrinsic conduction data is presented. The intrinsic conduction data includes intrinsic atrio-ventricular and interventricular delay intervals which may be collected via the sensing channels of an implantable cardiac device. Among the parameters which may be optimized in this manner are an atrio-ventricular delay interval and a biventricular offset interval. In one of its aspects, the invention provides for computing optimum pacing parameters for patients having some degree of AV block or with atrial conduction deficits. Another aspect of the invention relates to a pacing mode and configuration for providing cardiac resynchronization therapy to patients with a right ventricular conduction disorder.

摘要翻译： 提出了一种用于计算和/或设置从内在传导数据导出的最佳心脏再同步起搏参数的方法或系统。 内在传导数据包括可通过可植入心脏装置的感测通道收集的本征心室和室间延迟间隔。 可以以这种方式优化的参数是心房延迟间隔和双心室偏移间隔。 在其一个方面，本发明提供了对具有一定程度的AV阻滞或具有心房传导缺陷的患者计算最佳起搏参数。 本发明的另一方面涉及用于向患有右心室传导障碍的患者提供心脏再同步治疗的起搏模式和配置。

公开(公告)号：US07904155B2

公开(公告)日：2011-03-08

申请号：US11549676

申请日：2006-10-16

申请人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

发明人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

IPC分类号： A61N1/365

CPC分类号： A61N1/36578 ,  A61N1/3627 ,  A61N1/36542 ,  A61N1/3684

摘要： Methods and devices are disclosed for employing mechanical measurements to synchronize contractions of ventricular wall locations. Accelerometers that may be placed within electrode leads are positioned at ventricular wall locations, such as the left ventricle free wall, right ventricle free wall, and the anterior wall/septum wall. The accelerometers produce signals in response to the motion of the ventricular wall locations. A processor may then compare the signals to determine a difference in the synchronization of the ventricular wall location contractions. The difference in synchronization can be determined in various ways such as computing a phase difference and/or amplitude difference between the accelerometer signals. One or more stimulation pulses may be provided per cardiac cycle to resynchronize the contractions as measured by the accelerometers to thereby constantly and automatically optimize the cardiac resynchronization therapy.

摘要翻译： 公开了用于采用机械测量来同步心室壁位置收缩的方法和装置。 可以放置在电极引线内的加速度计定位在心室壁位置，例如左心室游离壁，右心室游离壁和前壁/隔膜壁。 加速度计响应于心室壁位置的运动产生信号。 然后，处理器可以比较信号以确定心室壁位置收缩的同步的差异。 可以以各种方式确定同步差异，例如计算加速度计信号之间的相位差和/或振幅差。 可以在每个心动周期提供一个或多个刺激脉冲，以重新同步由加速度计测量的收缩，从而不断地和自动地优化心脏再同步治疗。

公开(公告)号：US07890172B2

公开(公告)日：2011-02-15

申请号：US11654938

申请日：2007-01-18

申请人： Barun Maskara ,  Yinghong Yu

发明人： Barun Maskara ,  Yinghong Yu

IPC分类号： A69N1/365

CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

摘要： Cardiac therapy systems include multiple electrodes respectively positionable at multiple left ventricular electrode sites. A pulse generator is coupled to the electrodes and configured to deliver a cardiac resynchronization therapy (CRT). A processor is configured to measure, for each left ventricular electrode site, a timing interval between first and second cardiac signal features associated with left ventricular depolarization. The timing interval is associated with a degree of responsiveness of each left ventricular electrode site to CRT. The processor is configured to determine a pacing output configuration that provides improved patient responsiveness to CRT based on the timing interval measurements and to select at least one left ventricular electrode site from the plurality of left ventricular electrode sites based on the timing interval measurements. The processor may be configured to monitor for a change in hemodynamic status of the patient based on a change in the timing interval.

摘要翻译： 心脏治疗系统包括分别位于多个左心室电极部位的多个电极。 脉冲发生器耦合到电极并且被配置为递送心脏再同步治疗（CRT）。 处理器被配置为针对每个左心室电极部位测量与左心室去极化相关联的第一和第二心脏信号特征之间的定时间隔。 时间间隔与每个左心室电极部位对CRT的响应程度相关。 处理器被配置为确定起搏输出配置，其基于时间间隔测量提供对CRT的改善的患者响应性，并且基于时间间隔测量从多个左心室电极位置中选择至少一个左心室电极部位。 处理器可以被配置为基于时间间隔的变化来监视患者的血液动力学状态的变化。

公开(公告)号：US07613514B2

公开(公告)日：2009-11-03

申请号：US11109603

申请日：2005-04-19

申请人： Richard Fogoros ,  Jiang Ding ,  Yinghong Yu

发明人： Richard Fogoros ,  Jiang Ding ,  Yinghong Yu

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3684

摘要： A method and system for calculating an atrio-ventricular delay interval based upon an inter-atrial delay exhibited by a patient's heart. The aforementioned atrio-ventricular delay interval may optimize the stroke volume exhibited by a patient's heart. The aforementioned atrio-ventricular delay interval may be blended with another atrio-ventricular delay interval that may optimize another performance characteristic, such as left ventricular contractility. Such blending may include finding an arithmetic mean, geometric mean, or weighted mean of two or more proposed atrio-ventricular delay intervals.

摘要翻译： 一种用于根据患者心脏表现的心房间延迟来计算心房延迟间隔的方法和系统。 上述的心室延迟间隔可以优化患者心脏展示的搏动量。 上述房室延迟间隔可以与可以优化另一性能特征（例如左心室收缩力）的另一心房延迟间隔混合。 这种混合可以包括找到两个或更多个提出的心房延迟间隔的算术平均值，几何平均值或加权平均值。

公开(公告)号：US20090163970A1

公开(公告)日：2009-06-25

申请号：US12336064

申请日：2008-12-16

申请人： Yinghong Yu ,  Jiang Ding

发明人： Yinghong Yu ,  Jiang Ding

IPC分类号： A61N1/362

CPC分类号： A61N1/368 ,  A61B5/0452 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

摘要： At least one of a left intraventricular conduction defect, a right intraventricular conduction defect, or no intraventricular conduction defect can be detected using received intrinsic cardiac information from a subject, and a first atrioventricular (AV) delay can be calculated using a first relationship if the left intraventricular conduction defect or no intraventricular conduction defect is detected, or a second AV delay can be calculated using a second relationship if the right intraventricular conduction defect is detected.

摘要翻译： 可以使用来自受试者的接收的固有心脏信息来检测左室内传导缺陷，右心室内传导缺陷或无心室内传导缺陷中的至少一个，并且可以使用第一关系来计算第一房室（AV）延迟，如果 如果检测到右心室传导缺陷，则检测到左心室内传导缺陷或无心室传导缺陷，或者可以使用第二关系计算第二AV延迟。

公开(公告)号：US20090054945A1

公开(公告)日：2009-02-26

申请号：US11894082

申请日：2007-08-20

申请人： Abhilash Patangay ,  Jiang Ding ,  Jonathan T. Kwok ,  Barun Maskara ,  Yinghong Yu

发明人： Abhilash Patangay ,  Jiang Ding ,  Jonathan T. Kwok ,  Barun Maskara ,  Yinghong Yu

IPC分类号： A61N1/05 ,  A61N1/04

CPC分类号： A61N1/36564 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

摘要： Optimizing cardiac preload based on measured pulmonary artery pressure involves varying, for each repetition of an acute burst protocol, a parameter of pacing applied to a patient's heart during the acute burst protocol. Pulmonary artery pressure is measured during the repetitions of the acute burst protocol. An optimum ventricular preload is determined based on the measured pulmonary artery pressure. Pacing therapy is provided using a value of the parameter that is selected based on the determination of optimum ventricular preload.

摘要翻译： 基于测量的肺动脉压优化心脏预压，对于急性突发协议的每个重复，涉及在急性突发协议期间应用于患者心脏的起搏参数的变化。 在急性突发方案的重复期间测量肺动脉压。 基于测量的肺动脉压力确定最佳心室预负荷。 使用基于最佳心室预压的确定选择的参数值来提供起搏治疗。

公开(公告)号：US20070150013A1

公开(公告)日：2007-06-28

申请号：US11681244

申请日：2007-03-02

申请人： Jiang Ding ,  Yinghong Yu ,  Bruce KenKnight

发明人： Jiang Ding ,  Yinghong Yu ,  Bruce KenKnight

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

摘要： A method or system for computing and/or setting optimal cardiac resynchronization pacing parameters as derived from intrinsic conduction data is presented. The intrinsic conduction data includes intrinsic atrio-ventricular and interventricular delay intervals which may be collected via the sensing channels of an implantable cardiac device. Among the parameters which may be optimized in this manner are an atrio-ventricular delay interval and a biventricular offset interval. In one of its aspects, the invention provides for computing optimum pacing parameters for patients having some degree of AV block or with atrial conduction deficits. Another aspect of the invention relates to a pacing mode and configuration for providing cardiac resynchronization therapy to patients with a right ventricular conduction disorder.

摘要翻译： 提出了一种用于计算和/或设置从内在传导数据导出的最佳心脏再同步起搏参数的方法或系统。 内在传导数据包括可通过可植入心脏装置的感测通道收集的本征心室和室间延迟间隔。 可以以这种方式优化的参数是心房延迟间隔和双心室偏移间隔。 在其一个方面，本发明提供了对具有一定程度的AV阻滞或具有心房传导缺陷的患者计算最佳起搏参数。 本发明的另一方面涉及用于向患有右心室传导障碍的患者提供心脏再同步治疗的起搏模式和配置。