公开(公告)号：US20200010467A1

公开(公告)日：2020-01-09

申请号：US16305414

申请日：2017-06-02

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Boyu HU ,  Charles Z. DING ,  Zhigang HUANG ,  Ruibin LIN ,  Minliang XIAO ,  Jinsheng XIE ,  Shuhui CHEN ,  Cheng LI

IPC: C07D471/08 ,  A61P31/04

Abstract: Disclosed in the present invention is a type of novel β-lactamase inhibitors, and specifically disclosed are a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US10519133B2

公开(公告)日：2019-12-31

申请号：US15750704

申请日：2016-08-03

Applicant: MEDSHINE DISCOVERY INC. ,  HARBIN ZHENBAO PHARMACEUTICAL CO., LTD.

Inventor： Shuhui Chen ,  Zhengxia Chen ,  Meibi Dai ,  Cheng Xie ,  Peng Li ,  Yang Zhang ,  Guibai Liang ,  Qiang Wang ,  Jiangpeng Liao ,  Fei Sun ,  Guoping Hu ,  Jian Li

IPC: C07D401/14 ,  C07D405/14 ,  C07D401/12 ,  C07D413/14 ,  A61P35/00 ,  C07D403/02 ,  C07D403/14 ,  A61K31/416 ,  A61K31/395 ,  C07D235/02 ,  C07D401/02

Abstract: FGFR and VEGFR inhibitors are provided, and compounds represented by formula (1) or formula (II) as FGFR and VEGFR inhibitors, pharmaceutically acceptable salts or tautomers thereof are specifically disclosed.

公开(公告)号：US10280229B2

公开(公告)日：2019-05-07

申请号：US15326386

申请日：2015-07-13

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Chun Sing Li ,  Jian Li ,  Yong Cang ,  Shuhui Chen ,  Gang Li ,  Xiongbin Xu ,  Lun Lu

IPC: A61K47/68 ,  C07K16/30 ,  C07K16/28 ,  C07K19/00

Abstract: The present invention relates to linkers, containing amide surrogates with a regular or a novel lysosomal enzymatic cleavable dipeptidic unit, to connect cytotoxic drugs to antibodies. The present invention also relates to ADCs (antibody-drug conjugates) derived from these amide surrogate linkers for the treatment of cancers.

公开(公告)号：US09969719B2

公开(公告)日：2018-05-15

申请号：US15557210

申请日：2016-03-10

Applicant: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. ,  MEDSHINE DISCOVERY INC.

Inventor： Charles Z. Ding ,  Shuhui Chen ,  Baoping Zhao ,  Zhaobing Xu ,  Yingchun Liu ,  Ruibin Lin ,  Fei Wang ,  Jian Li

IPC: C07D403/14 ,  C07D401/14 ,  C07D471/04 ,  C07D487/10 ,  C07D498/04 ,  C07D487/08

CPC classification number: C07D403/14 ,  C07D401/14 ,  C07D471/04 ,  C07D487/08 ,  C07D487/10 ,  C07D498/04

Abstract: Disclosed is a substituted 2H-pyrazole derivative serving as a selective CDK4/6 inhibitor. Specifically, disclosed is a compound of formula (I) or a pharmaceutically acceptable salt thereof which serves as a selective CDK4/6 inhibitor.

公开(公告)号：US20170202974A1

公开(公告)日：2017-07-20

申请号：US15326386

申请日：2015-07-13

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Chun Sing LI ,  Jian LI ,  Yong CANG ,  Shuhui CHEN ,  Gang LI ,  Xiongbin XU ,  Lun LU

IPC: A61K47/48 ,  C07K16/30 ,  C07K16/28 ,  C07K19/00

CPC classification number: C07K16/3015 ,  A61K47/6803 ,  A61K47/6817 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6889 ,  C07K16/2863 ,  C07K2317/24

Abstract: The present invention relates to linkers, containing amide surrogates with a regular or a novel lysosomal enzymatic cleavable dipeptidic unit, to connect cytotoxic drugs to antibodies. The present invention also relates to ADCs (antibody-drug conjugates) derived from these amide surrogate linkers for the treatment of cancers.

公开(公告)号：US20170037050A1

公开(公告)日：2017-02-09

申请号：US15306965

申请日：2015-04-21

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Lingyun WU ,  Yuanshan YAO ,  Zhaoguo CHEN ,  Shuhui CHEN

IPC: C07D487/04 ,  C07D401/12 ,  C07D471/04

CPC classification number: C07D487/04 ,  A61K31/4725 ,  A61K31/55 ,  C07D401/12 ,  C07D471/04

Abstract: The present invention discloses a class of isoquinolinesulfonyl derivatives as RHO kinase inhibitors, and pharmaceutical compositions thereof, and relates to pharmaceutically acceptable uses thereof. Specifically, the present invention relates to a compound as represented by formula (I), or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明公开了一类作为RHO激酶抑制剂的异喹啉磺酰基衍生物及其药物组合物，并且涉及其药学上可接受的用途。 具体而言，本发明涉及由式（I）表示的化合物或其药学上可接受的盐。

公开(公告)号：US20250034099A1

公开(公告)日：2025-01-30

申请号：US18569867

申请日：2022-06-14

Applicant: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. ,  MEDSHINE DISCOVERY INC.

Inventor： Lingyun WU ,  Zheming XIAO ,  Yi CHEN ,  Xiongbin XU ,  Wei XIA ,  Tangyang GUO ,  Lan CAO ,  Chi-chung CHAN ,  Qiu LI ,  Jian LI ,  Shuhui CHEN

IPC: C07D265/36 ,  A61K31/538 ,  A61P13/12 ,  C07D413/14

Abstract: A class of benzoxazinone derivatives and a preparation method therefor, specifically related to a compound shown in formula (II), or a stereoisomer or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240409543A1

公开(公告)日：2024-12-12

申请号：US18703171

申请日：2022-10-27

Applicant: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. ,  MEDSHINE DISCOVERY INC.

Inventor： Xiangyu FU ,  Charles Z. DING ,  Lihong HU

IPC: C07D471/20 ,  A61K31/497 ,  A61P35/00

Abstract: Disclosed are a pyrrolopyrazole spiro compound, and the use thereof in preparing a drug for treating related diseases. The present invention specifically relates to a compound as represented by formula (I′), and a stereoisomer and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240390388A1

公开(公告)日：2024-11-28

申请号：US18262724

申请日：2022-01-25

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Jingjie HUANG ,  Tao YU ,  Ye TAN ,  Chengde WU ,  Shuhui CHEN

IPC: A61K31/553 ,  C07D498/04 ,  C07D519/00

Abstract: A series of tricyclic compounds and the use thereof. Specifically disclosed are a compound as represented by formula (II) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240376093A1

公开(公告)日：2024-11-14

申请号：US18573074

申请日：2022-06-22

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Wenyuan Qian ,  Chundao Yang

IPC: C07D417/14 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/541 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D411/14 ,  C07D471/04

Abstract: A sulfoximine compound and a use thereof. Specifically disclosed is a compound represented by the following formula or a pharmaceutically acceptable salt thereof.