公开(公告)号：US11440966B2

公开(公告)日：2022-09-13

申请号：US17345628

申请日：2021-06-11

Applicant: GENMAB A/S ,  BioNTech SE

Inventor： Isil Altintas ,  David Satijn ,  Rik Rademaker ,  Paul Parren ,  Friederike Gieseke ,  Ugur Sahin

IPC: C07K16/28 ,  A61K39/395 ,  G01N33/569

Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.

公开(公告)号：US20220265844A1

公开(公告)日：2022-08-25

申请号：US17548436

申请日：2021-12-10

Applicant: Genmab A/S

Inventor： Steen LISBY ,  Nancy Cherry WHITING

IPC: A61K47/68 ,  A61K38/07 ,  C07K16/36

Abstract: Anti-TF antibody drug conjugate and pharmaceutical compositions comprising the antibody drug-conjugate for use in the treatment of a solid cancer comprising administering to a subject a weekly dose of from about 0.8 mg/kg to about 1.8 mg/kg of an anti-TF antibody drug conjugate once a week for three consecutive weeks followed by a one week resting period without any administration of anti-TF ADC so that each cycle time is 28 days including the resting period.

公开(公告)号：US20220119544A1

公开(公告)日：2022-04-21

申请号：US17558430

申请日：2021-12-21

Applicant: GENMAB A/S

Inventor： Brian Elliott ,  Tahamtan AHMADI ,  Christopher W.L. CHIU ,  Esther C.W BREIJ ,  Ida HIEMSTRA ,  Maria N. JURE-KUNKEL

IPC: C07K16/28 ,  A61P35/00 ,  A61K31/675 ,  A61K39/395 ,  A61K31/704 ,  A61K31/475 ,  A61K31/573

Abstract: Provided are methods of clinical treatment of diffuse large B-cell lymphoma (DLBCL) (e.g., previously untreated, high-risk DLBCL) in human subjects using a bispecific antibody which binds to CD3 and CD20 in combination with standard of care regimen of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone).

公开(公告)号：US20220112309A1

公开(公告)日：2022-04-14

申请号：US17559965

申请日：2021-12-22

Applicant: GENMAB A/S

Inventor： Brian ELLIOTT ,  Tahamtan AHMADI ,  Patricia Garrido CASTRO

IPC: C07K16/46 ,  C07K16/28 ,  A61P35/00 ,  A61K31/282

Abstract: Provided are methods of clinical treatment of diffuse large B-cell lymphoma (DLBCL) (e.g., relapsed and/or refractory DLBCL ineligible for autologous stem cell transplant) in human subjects using a bispecific antibody which binds to CD3 and CD20 in combination with standard of care regimen of gemcitabine and oxaliplatin (GemOx).

公开(公告)号：US20220112301A1

公开(公告)日：2022-04-14

申请号：US17560006

申请日：2021-12-22

Applicant: Genmab A/S

Inventor： Brian Elliott ,  Tahamtan Ahmadi

IPC: C07K16/28 ,  A61K31/573 ,  A61K31/7072 ,  A61P35/00 ,  A61K31/555

Abstract: Provided are methods of clinical treatment of diffuse large B-cell lymphoma (DLBCL) (e.g., relapsed and/or refractory DLBCL eligible for autologous stem cell transplant) in human subjects using a bispecific antibody which binds to CD3 and CD20 in combination with standard of care regimen of R-DHAX/C (rituximab, dexamethasone, cytarabine, and oxaliplatin/carboplatin).

公开(公告)号：US20220064317A1

公开(公告)日：2022-03-03

申请号：US17360437

申请日：2021-06-28

Applicant: GENMAB A/S ,  BioNTech SE

Inventor： Isil ALTINTAS ,  David SATIJN ,  Rik RADEMAKER ,  Paul PARREN ,  Friederike GIESEKE ,  Ugur SAHIN

IPC: C07K16/28 ,  A61K39/395 ,  G01N33/569

Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.

公开(公告)号：US11230604B2

公开(公告)日：2022-01-25

申请号：US15909540

申请日：2018-03-01

Applicant: GENMAB A/S

Inventor： Michel De Weers ,  Tim Walseth ,  Jan Van De Winkel ,  Tom Vink ,  Paul Parren

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  G01N33/573

Abstract: Isolated monoclonal antibodies which bind to human CD38 and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies.

公开(公告)号：US20210393793A1

公开(公告)日：2021-12-23

申请号：US17279359

申请日：2019-09-26

Applicant: GENMAB A/S

Inventor： Esther BREIJ ,  Ulf FORSSMANN ,  Tahamtan AHMADI

IPC: A61K47/68 ,  C07K16/28 ,  A61P35/00 ,  A61K9/00

Abstract: The present invention relates to immunoconjugates anti-AXL antibodies and compositions for treatment of non-small cell lung cancer.

公开(公告)号：US20210292418A1

公开(公告)日：2021-09-23

申请号：US17204604

申请日：2021-03-17

Applicant: GENMAB A/S

Inventor： Louise KOOPMAN ,  Patrick ENGELBERTS ,  Dennis VERZIJL ,  Edward N. VAN DEN BRINK ,  Rik RADEMAKER ,  Sieto BOSGRA ,  Frederikke L. EGEROD ,  David SATIJN ,  Esther C. W. BREIJ

IPC: C07K16/28 ,  A61P35/00

Abstract: The present invention relates to antibodies binding to B7H4, including bispecific antibodies binding to B7H4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.

公开(公告)号：US11091557B2

公开(公告)日：2021-08-17

申请号：US16316534

申请日：2017-07-14

Applicant: GENMAB A/S ,  BioNTech SE

Inventor： Isil Altintas ,  David Satijn ,  Rik Rademaker ,  Paul Parren ,  Friederike Gieseke ,  Ugur Sahin

IPC: A61K39/395 ,  C07K16/28 ,  G01N33/569

Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.