公开(公告)号：US20050266089A1

公开(公告)日：2005-12-01

申请号：US11192718

申请日：2005-07-29

Applicant: James Cook ,  Stanley Huth

Inventor： James Cook ,  Stanley Huth

IPC: A61K9/00 ,  A61K31/728 ,  A61K33/00 ,  A61K45/06 ,  A61P27/00 ,  A61P27/02 ,  A61K33/14

CPC classification number: A61K9/0048 ,  A61K31/728 ,  A61K33/00 ,  A61K45/06 ,  A61K2300/00

Abstract: Stable ophthalmic formulations comprising hyaluronic acid (sodium hyaluronate) as the primary active demulcent ingredient, stabilized oxy-chloro complex (available commercially as OcuPure™ from Advanced Medical Optics, Purite® from Allergan, and Purogene from Biocide) for preservative efficacy, balanced salts mimicking the tear film, and sodium borate as a buffer are disclosed. In one embodiment, preferred stable formulations may be used in the human eye with or without contact lenses. In another embodiment preferred formulations may also be used as a storage and conditioning solution for contact lenses following disinfection.

Abstract translation: 包含透明质酸（透明质酸钠）作为主要的活性缓和成分的稳定的眼用制剂，稳定的氯 - 氯络合物（可从Advanced Medical Optics，Allergan的Purite，以及来自Biocide的Purogene购得），用于防腐​​功效 公开了模仿泪膜的平衡盐和作为缓冲剂的硼酸钠。 在一个实施方案中，优选的稳定制剂可以在具有或不具有隐形眼镜的人眼中使用。 在另一个实施方案中，优选的制剂也可以用作消毒后的隐形眼镜的储存和调理溶液。

公开(公告)号：US20050167775A1

公开(公告)日：2005-08-04

申请号：US10913297

申请日：2004-08-05

Applicant: Walter Nagy ,  Ricardo Borges ,  Jeffrey Brown ,  Apurva Chaudhari ,  James Cook ,  Allen Hanson ,  Jerry Johnson ,  Kevin Linthicum ,  Edwin Piner ,  Pradeep Rajagopal ,  John Roberts ,  Sameer Singhal ,  Robert Therrien ,  Andrei Vescan

Inventor： Walter Nagy ,  Ricardo Borges ,  Jeffrey Brown ,  Apurva Chaudhari ,  James Cook ,  Allen Hanson ,  Jerry Johnson ,  Kevin Linthicum ,  Edwin Piner ,  Pradeep Rajagopal ,  John Roberts ,  Sameer Singhal ,  Robert Therrien ,  Andrei Vescan

IPC: H01L29/15 ,  H01L29/20 ,  H01L29/778 ,  H01L29/812

CPC classification number: H01L29/812 ,  H01L29/2003 ,  H01L29/7787

Abstract: Gallium nitride material transistors and methods associated with the same are provided. The transistors may be used in power applications by amplifying an input signal to produce an output signal having increased power. The transistors may be designed to transmit the majority of the output signal within a specific transmission channel (defined in terms of frequency), while minimizing transmission in adjacent channels. This ability gives the transistors excellent linearity which results in high signal quality and limits errors in transmitted data. The transistors may be designed to achieve low ACPR values (a measure of excellent linearity), while still operating at high drain efficiencies and/or high output powers. Such properties enable the transistors to be used in RF power applications including third generation (3G) power applications based on W-CDMA modulation.

Abstract translation: 提供了氮化镓材料晶体管和与之相关的方法。 晶体管可以通过放大输入信号来产生具有增加的功率的输出信号在功率应用中使用。 晶体管可以设计成在特定传输信道（以频率定义）的情况下传输大部分输出信号，同时最小化相邻信道中的传输。 这种能力使晶体管具有良好的线性度，导致高信号质量并限制了传输数据中的误差。 晶体管可以设计成实现低ACPR值（优良线性度量），同时仍然以高漏电效率和/或高输出功率工作。 这种特性使晶体管能够用于包括基于W-CDMA调制的第三代（3G）功率应用的射频功率应用中。

公开(公告)号：US06642039B1

公开(公告)日：2003-11-04

申请号：US09791165

申请日：2001-02-22

Applicant: William James Cook ,  Rory A. J. Curtis ,  Frank Spaltmann

Inventor： William James Cook ,  Rory A. J. Curtis ,  Frank Spaltmann

IPC: C12N1914

CPC classification number: C12N9/78

Abstract: The present invention relates to a newly identified human agmatinase-like arginase, designated “25312”. The invention also relates to polynucleotides encoding the agmatinase-like arginase. The invention further relates to methods using the agmatinase-like polypeptides and polynucleotides as a target for diagnosis and treatment in disorders mediated by or related to the agmatinase-like arginase. The invention further relates to drug-screening methods using the polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the polypeptides and polynucleotides. The invention further relates to agonists and antagonists identified by drug screening methods with the polypeptides and polynucleotides as a target.

公开(公告)号：US5792735A

公开(公告)日：1998-08-11

申请号：US839344

申请日：1997-04-18

Applicant: Stephen James Cook ,  Sean Patrick O'Connor ,  John Crawford

Inventor： Stephen James Cook ,  Sean Patrick O'Connor ,  John Crawford

IPC: C10M169/04 ,  C10M159/20 ,  C10M159/22 ,  C10M163/00 ,  C10N20/00 ,  C10N30/04 ,  C10N40/25 ,  F02B3/06 ,  F02B75/02 ,  C10M159/24

CPC classification number: C10M159/22 ,  C10M159/20 ,  C10M163/00 ,  C10M2207/028 ,  C10M2207/125 ,  C10M2207/129 ,  C10M2207/144 ,  C10M2207/26 ,  C10M2207/262 ,  C10M2219/044 ,  C10M2219/046 ,  C10M2219/089 ,  C10N2240/102 ,  C10N2240/103 ,  C10N2240/105 ,  C10N2270/02 ,  F02B2075/027 ,  F02B3/06

Abstract: A lubricating oil composition suitable for use in low or medium speed diesel engines comprises a fuel oil with a residual oil content characterised in that the lubricating oil composition further comprises a hydrocarbyl-substituted phenate concentrate having a TBN greater than 300, and at least one of a hydrocarbyl-substituted salicylate and a hydrocarbyl-substitute sulphonate. The hydrocarbyl-substituted phenate is preferably one modified by incorporation of a carboxylic acid of the formula RCH(R.sub.1)CO.sub.2 H where R is a C.sub.10 -C.sub.24 alkyl group and R.sub.1 is hydrogen or a C.sub.1 to C.sub.4 alkyl group e.g. stearic acid.

Abstract translation: 适用于低速或中速柴油发动机的润滑油组合物包括具有残油含量的燃油，其特征在于所述润滑油组合物还包含TBN大于300的烃基取代的酚盐浓缩物，以及至少一种 烃基取代的水杨酸盐和烃基取代的磺酸盐。 烃基取代的酚盐优选通过掺入式RCH（R 1）CO 2 H的羧酸，其中R是C 10 -C 24烷基，R 1是氢或C 1至C 4烷基，例如， 硬脂酸。

公开(公告)号：US5674821A

公开(公告)日：1997-10-07

申请号：US371552

申请日：1995-01-11

Applicant: Stephen James Cook ,  Sean Patrick O'Connor ,  John Crawford

Inventor： Stephen James Cook ,  Sean Patrick O'Connor ,  John Crawford

IPC: C10M159/22 ,  C10N20/00 ,  C10N20/02 ,  C10N30/04 ,  C10N40/25 ,  C10N60/00 ,  C10N70/00

CPC classification number: C10M159/22 ,  C10M2207/028 ,  C10M2207/262 ,  C10M2219/089

Abstract: A detergent concentrate composition suitable for incorporation into a finished lubricating oil comprises: (A) an additive concentrate comprising: (a) a lubricating oil, and (b) a lubricating oil soluble sulphurized or non-sulphurized alkaline earth metal hydrocarbyl phenate modified by reaction to incorporate from greater than 2 to less than 40% by weight based on the weight of the concentrate (A) of either (i) at least one carboxylic acid having the formula: ##STR1## wherein R is a C.sub.10 to C.sub.24 alkyl or alkenyl group and R.sup.1 is either hydrogen, a C.sub.1 to C.sub.4 alkyl group or a --CH.sub.2 --COOH group, or an anhydride or ester thereof, or (ii) a di- or polycarboxylic acid containing from 36 to 100 carbon atoms or an anhydride or ester thereof, the concentrate having a BN greater than 300 and a viscosity at 100.degree. C. of less than 1000 cSt, and (B) an additive concentrate comprising: (a) a lubricating oil, and (b) a lubricating oil soluble sulphurized or non-sulphurized alkaline earth metal hydrocarbyl phenate, that has not been modified or has been modified by reaction to incorporate less than 0.1% by weight based on the weight of the concentrate (B) of either (i) or (ii), the concentrate preferably having a BN of less than 300.

Abstract translation: 适于掺入成品润滑油的洗涤剂浓缩物组合物包括：（A）添加剂浓缩物，其包含：（a）润滑油，和（b）通过反应改性的润滑油可溶性硫化或非硫化碱土金属烃基酚盐 基于（i）至少一种具有下式的羧酸（I）的浓缩物（A）的重量，从大于2至小于40重量％掺入，其中R为C10至C24 烷基或烯基，R 1为氢，C 1〜C 4烷基或-CH 2 -COOH基，或其酸酐或酯，或（ⅱ）含有36〜100个碳原子的二元或多元羧酸或 酸酐或其酯，浓缩物的BN大于300，100℃下的粘度小于1000cSt，和（B）添加剂浓缩物，其包含：（a）润滑油，和（b）润滑油 可溶性硫化或非硫化碱土金属氢化汽油 （I）或（ii）的浓缩物（B）的重量小于0.1重量％的反应而未被修饰或已经被改性，所述浓缩物优选具有BN少于 超过300。