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    PREDICTIVE BIOMARKERS FOR ADVERSE EFFECTS OF RADIATION THERAPY
    11.
    发明申请
    PREDICTIVE BIOMARKERS FOR ADVERSE EFFECTS OF RADIATION THERAPY 有权

    公开(公告)号：US20220065863A1

    公开(公告)日：2022-03-03

    申请号：US17476148

    申请日：2021-09-15

    申请人： Georgetown University

    发明人： Anatoly Dritschilo ,  Amrita K. Cheema ,  Scott Grindrod ,  Xiaogang Zhong

    IPC分类号： G01N33/574 ,  A61N5/10

    摘要： Methods of treating with radiation therapy a subject having cancer, in which the method comprises administering radiation therapy to the subject. The subject does not have an increased risk of having an adverse reaction to radiation therapy. The subject has an increased risk of an adverse reaction to radiation therapy when the subject's level of each component in a component profile from a sample of the subject is altered as compared to the normal level of each component. The component profile may comprise a metabolite panel of geranyl pyrophosphate, glucose-1-phosphate, and 3-hydroxy-3-methylglutaryl-CoA; a lipid panel of LPA 18:0, LPA 16:0, LPC 20:2, CER 24:0, and LPI 16:1; or a combination of these panels. The component profile may also comprise a metabolite panel of metanephrine, tryptophan, xanthurenic acid, and pantothenate; a lipid panel of LPA 18:0, DAG 16:0/18:0, LPA 16:0, and DAG 18:1/18:1; or a combination of these panels.

    DETECTING INFECTION USING SURROGATES
    12.
    发明申请
    DETECTING INFECTION USING SURROGATES 有权

    公开(公告)号：US20210383935A1

    公开(公告)日：2021-12-09

    申请号：US17406598

    申请日：2021-08-19

    申请人： Georgetown University

    发明人： Howard Federoff ,  Ophir Frieder

    IPC分类号： G16H50/80 ,  G16H50/30 ,  G16H40/67 ,  G10L25/66

    摘要： A triage system that determines whether a user is likely to have contracted a disease based on sensor data received from a user device (e.g., a smartphone or activity tracker). Each symptom is identified by comparing sensor data to a predetermined baseline and comparing the difference to a predetermined symptom threshold. Because direct measurement of symptoms using the sensors available to the user may not be feasible or sufficiently accurate, the triage system also uses surrogates the identify certain symptoms. For example, a fever may be identified using heart data, a cough or shortness of breath may be identified by analyzing recorded sound, fatigue may be identified by analyzing the movement of the user device, and loss of smell or taste may be identified by recording sound and using speech detection algorithms to identify phrases in the recorded sound indicative of loss of smell or taste.

    Cache optimization via topics in web search engines
    13.
    发明授权
    Cache optimization via topics in web search engines 有权

    公开(公告)号：US11151167B2

    公开(公告)日：2021-10-19

    申请号：US16654725

    申请日：2019-10-16

    申请人： Georgetown University

    发明人： Ophir Frieder ,  Ida Mele ,  Raffaele Perego ,  Nicola Tonellotto

    IPC分类号： G06F16/00 ,  G06F16/28 ,  G06F16/2452 ,  G06N20/00 ,  G06F40/30 ,  G06F16/953

    摘要： Embodiments may provide a cache for query results that can adapt the cache-space utilization to the popularity of the various topics represented in the query stream. For example, a method for query processing may perform receiving a plurality of queries for data, determining at least one topic associated with each query, and requesting data responsive to each query from a data cache comprising a plurality of partitions, including at least a static cache partition, a dynamic cache partition, and a temporal cache partition, the temporal cache partition may store data based on a topic associated with the data, and may be further partitioned into a plurality of topic portions, each portion may store data relating to an associated topic, wherein the associated topic may be selected from among determined topics of queries received by the computer system, and the data cache may retrieve data for the queries from the computer system.

    TARGETED LIPOSOMES
    15.
    发明申请
    TARGETED LIPOSOMES 有权

    公开(公告)号：US20210205456A1

    公开(公告)日：2021-07-08

    申请号：US17168614

    申请日：2021-02-05

    申请人： GEORGETOWN UNIVERSITY

    发明人： Esther H. CHANG ,  SangSoo KIM ,  Antonina RAIT

    IPC分类号： A61K45/06 ,  A61K9/127 ,  A61K9/00

    摘要： The present invention is in the field of drug delivery, and specifically, cationic liposome-based drug delivery. In embodiments, this invention provides methods of making ligand-targeted (e.g., antibody- or antibody fragment-targeted) liposomes useful for the delivery of liposomes to tumors, including brain tumors. In embodiments, the liposomes deliver temozolomide across the blood-brain barrier for treatment of primary or metastatic brain tumors. Additional cancers that can be treated with the liposomes include neuroendocrine tumors, melanoma, prostate, head and neck, ovarian, lung, liver, kidney, breast, urogenital, gastric, colorectal, cervical, vaginal, angiosarcoma, liposarcoma, rhabdomyosarcoma, choriocarcinoma, pancreatic, retinoblastoma and other types of cancer. In another embodiment the liposomes deliver melphalan for the treatment of multiple myeloma, other tumors of the blood or other solid tumors. In still other embodiments the liposomes can deliver other drugs such as pemetrexed or irinotecan for treatment of cancer or drugs including atropine for treatment of organophosphate poisoning.

    Efficiently querying databases while providing differential privacy
    16.
    发明授权
    Efficiently querying databases while providing differential privacy 有权

    公开(公告)号：US10984130B2

    公开(公告)日：2021-04-20

    申请号：US16197813

    申请日：2018-11-21

    申请人： Georgetown University ,  Trustees of Boston University ,  Bornio, Inc.

    发明人： Yaacov Nissim Kobliner ,  Georgios Kellaris ,  George Kollios

    IPC分类号： G06F21/00 ,  G06F21/62 ,  G06F16/9535 ,  G06F16/2455 ,  G06F16/2453

    摘要： Technologies are provided for efficiently querying a database using a plurality of oblivious random-access memories (ORAMs) while providing differential privacy. Subsets of a set of database records can be stored in a plurality of ORAMs. The subsets of database records in the separate ORAMs can be concurrently accessed (for example, by a database query server). When a database query is received, a number of database records that match the query can be identified for each of the ORAMs. A differential privacy constraint can be used to determine an additional number of database records to be retrieved from each ORAM. The differential privacy constraint can specify an upper bound on the number of records to be retrieved from each ORAM to prevent (or reduce the risk of) information leakage. Once all of the identified records are retrieved from the plurality of ORAMs, the additional records can be discarded.