中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

18 records (took 0.016 seconds)

    METHODS FOR MODULATING PLANT RESPONSE TO ENVIRONMENTALLY-INDUCED STRESS
    1.
    发明申请
    METHODS FOR MODULATING PLANT RESPONSE TO ENVIRONMENTALLY-INDUCED STRESS 审中-公开

    公开(公告)号：US20180360043A1

    公开(公告)日：2018-12-20

    申请号：US16122712

    申请日：2018-09-05

    Applicant: Howard University ,  Georgetown University

    Inventor： Sivanesan Dakshanamurthy ,  Hemayet Ullah

    IPC: A01N43/653 ,  A01N43/38

    Abstract: Compounds and methods are described herein that are effective to modulate plant response (e.g., plant susceptibility) to environmentally-induced stress. The compounds and methods described herein advantageously may be used to modulate environmental stress resistance in a wide variety of plants. Environmental stresses include, for example, high light intensity (UV exposure), temperature (e.g., high heat), high soil salinity, and low soil moisture (e.g., drought). As used herein, environmental stresses include any conditions that result in increased generation of reactive oxygen species (ROS) and accumulation of ROS in the plant cells. The compounds described herein that are effective to modulate resistance to the stress prevent, directly or indirectly, or increase phosphorylation of Tyr248 of the RACK1A protein.

    Methods and systems for populating and searching a drug informatics database
    4.
    发明授权
    Methods and systems for populating and searching a drug informatics database 有权

    公开(公告)号：US11373734B2

    公开(公告)日：2022-06-28

    申请号：US14401633

    申请日：2013-05-20

    Applicant: Georgetown University

    Inventor： Sivanesan Dakshanamurthy ,  Oakland John Peter

    IPC: G06F16/00 ,  G16B50/00 ,  G06F16/248 ,  G06F16/21 ,  G16H70/40 ,  G16B50/20 ,  H04L67/10 ,  G16B45/00

    Abstract: The present invention provides a method for populating and searching a drug informatics database that includes receiving unprocessed data associated with a chemical compound from one or more data sources. The unprocessed data is parsed into a plurality of data objects based on a categorization associated with each of the data objects. Additional information, such as explanatory notes, is identified and associated with at least one of the data objects. The data objects are stored in entries within a data structure, where the data structure is searchable based on one or more of the data objects. A query for data associated with a chemical compound is received at a drug informatics database. The drug informatics database is then searched for data associated with the chemical compound and the search results are provided to a user.

    Methods for modulating plant response to environmentally-induced stress
    6.
    发明授权
    Methods for modulating plant response to environmentally-induced stress 有权

    公开(公告)号：US11737462B2

    公开(公告)日：2023-08-29

    申请号：US16122712

    申请日：2018-09-05

    Applicant: Howard University ,  Georgetown University

    Inventor： Sivanesan Dakshanamurthy ,  Hemayet Ullah

    IPC: A01N43/653 ,  A01N43/38

    CPC classification number: A01N43/653 ,  A01N43/38

    Abstract: Compounds and methods are described herein that are effective to modulate plant response (e.g., plant susceptibility) to environmentally-induced stress. The compounds and methods described herein advantageously may be used to modulate environmental stress resistance in a wide variety of plants. Environmental stresses include, for example, high light intensity (UV exposure), temperature (e.g., high heat), high soil salinity, and low soil moisture (e.g., drought). As used herein, environmental stresses include any conditions that result in increased generation of reactive oxygen species (ROS) and accumulation of ROS in the plant cells. The compounds described herein that are effective to modulate resistance to the stress prevent, directly or indirectly, or increase phosphorylation of Tyr248 of the RACK1A protein.

    Methods for treating viral infection
    7.
    发明授权
    Methods for treating viral infection 有权

    公开(公告)号：US11576901B2

    公开(公告)日：2023-02-14

    申请号：US16088392

    申请日：2017-03-27

    Applicant: HOWARD UNIVERSITY ,  GEORGETOWN UNIVERSITY

    Inventor： Hemayet Ullah ,  Sivanesan Dakshanamurthy

    IPC: A61K31/4196 ,  A61K45/06

    Abstract: A method effective in treating a viral infection involves administering a therapeutically effective amount of at least one compound capable of inhibiting expression of at least a portion of a virus genome containing an internal ribosomal entry site, or a pharmaceutically acceptable salt thereof. The compound has an azole moiety comprising a five member heterocyclic ring containing at least one nitrogen atom, a hydrophobic moiety bonded to the heterocyclic ring of the azole, and a donor/acceptor moiety bonded to the heterocyclic ring having at least one of hydrogen bond donor and a hydrogen bond acceptor.

    METHOD FOR PREDICTING DRUG-TARGET INTERACTIONS AND USES FOR DRUG REPOSITIONING
    8.
    发明申请
    METHOD FOR PREDICTING DRUG-TARGET INTERACTIONS AND USES FOR DRUG REPOSITIONING 审中-公开
    预防药物相互作用的方法和用于药物记录的方法

    公开(公告)号：US20150324546A1

    公开(公告)日：2015-11-12

    申请号：US14408316

    申请日：2013-06-21

    Applicant: GEORGETOWN UNIVERSITY

    Inventor： Sivanesan Dakshanamurthy ,  Stephen W. Byers

    IPC: G06F19/00

    CPC classification number: G06F19/3456 ,  G16B15/00 ,  G16C20/50

    Abstract: Described herein are methods of predicting drug-target interactions and method of using the information for drug repurposing. The methods described herein combine different descriptors including, for example, shape, topology and chemical signatures, physico-chemical functional descriptors, contact points of the ligand and the target protein, chemical similarity, and docking score.

    Abstract translation: 本文描述了预测药物靶标相互作用的方法以及使用该信息进行药物再利用的方法。 本文描述的方法组合了不同的描述符，包括例如形状，拓扑和化学特征，物理化学功能描述符，配体和靶蛋白的接触点，化学相似性和停泊分数。

    METHODS AND SYSTEMS FOR POPULATING AND SEARCHING A DRUG INFORMATICS DATABASE
    9.
    发明申请
    METHODS AND SYSTEMS FOR POPULATING AND SEARCHING A DRUG INFORMATICS DATABASE 审中-公开
    人口和搜索药物信息数据库的方法和系统

    公开(公告)号：US20150142730A1

    公开(公告)日：2015-05-21

    申请号：US14401633

    申请日：2013-05-20

    Applicant: Georgetown University

    Inventor： Sivanesan Dakshanamurthy ,  Oakland John Peter

    IPC: G06F17/30 ,  H04L29/08

    CPC classification number: G06F16/248 ,  G06F16/21 ,  G06F19/324 ,  G06F19/326 ,  G16B45/00 ,  G16B50/00 ,  H04L67/10

    Abstract: The present invention provides a method for populating and searching a drug informatics database that includes receiving unprocessed data associated with a chemical compound from one or more data sources. The unprocessed data is parsed into a plurality of data objects based on a categorization associated with each of the data objects. Additional information, such as explanatory notes, is identified and associated with at least one of the data objects. The data objects are stored in entries within a data structure, where the data structure is searchable based on one or more of the data objects. A query for data associated with a chemical compound is received at a drug informatics database. The drug informatics database is then searched for data associated with the chemical compound and the search results are provided to a user.

    Abstract translation: 本发明提供了一种用于填充和搜索药物信息数据库的方法，其包括从一个或多个数据源接收与化合物相关联的未处理数据。 基于与每个数据对象相关联的分类，将未处理的数据解析成多个数据对象。 附加信息（如说明注释）被识别并与至少一个数据对象相关联。 数据对象存储在数据结构内的条目中，其中数据结构可以基于一个或多个数据对象来搜索。 在药物信息学数据库中接收与化合物相关联的数据的查询。 然后搜索药物信息学数据库与化学化合物相关的数据，并将搜索结果提供给用户。

    Methods for treating virus infection or proliferation
    10.
    发明授权
    Methods for treating virus infection or proliferation 有权

    公开(公告)号：US11596623B2

    公开(公告)日：2023-03-07

    申请号：US17289558

    申请日：2019-10-29

    Applicant: HOWARD UNIVERSITY ,  GEORGETOWN UNIVERSITY

    Inventor： Hemayet Ullah ,  Sivanesan Dakshanamurthy

    IPC: A61K31/4196

    Abstract: A method for treating against, or at least inhibiting or suppressing, the proliferation of an internal ribosome entry site-utilizing virus (IRES-utilizing virus) involves administering a compound, a tautomer, or a pharmaceutically acceptable salt thereof, in an amount effective for inhibiting replication of the IRES-utilizing virus in cells, wherein the compound is represented by the formula: wherein each R1 is independent of the other and represents a halogen atom selected from the group consisting of bromo, chloro, fluoro and iodo.

Patent Agency Ranking