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公开(公告)号：US08697719B2
公开(公告)日：2014-04-15
申请号：US13386550
申请日：2010-08-06
IPC分类号： A61K31/437 , A61P11/00 , A61P11/06 , C07D491/18
CPC分类号： C07D491/18 , C07D451/10
摘要： Novel Anhydrate The present invention relates to a novel form of anhydrous tiotropium bromide, processes for the preparation of anhydrous tiotropium bromide, pharmaceutical compositions comprising anhydrous tiotropium bromide and uses of the compositions.
摘要翻译： 新型无水物技术领域本发明涉及一种新型无水噻托溴铵，制备无水噻托溴铵的方法，含有无水噻托溴铵的药物组合物和组合物的用途。
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公开(公告)号：US08664390B2
公开(公告)日：2014-03-04
申请号：US12665997
申请日：2008-06-27
申请人： Abhay Gaitonde , Bindu Manojkumar , Sandeep Sonawane , Dattatrey Kokane , Sandeep Mekde , Dattatraya Shinde , Prakash Bansode
发明人： Abhay Gaitonde , Bindu Manojkumar , Sandeep Sonawane , Dattatrey Kokane , Sandeep Mekde , Dattatraya Shinde , Prakash Bansode
IPC分类号： C07D403/04 , A61K31/505
CPC分类号： C07D239/69
摘要： The present invention relates to an improved process for the preparation of bosentan. In particular it relates to a process for preparing bosentan substantially free from the dimer impurity of formula (II) and the 6-hydroxy impurity of formula (III). The invention also relates to a pharmaceutical composition comprising bosentan and its use in the treatment of endothelin-receptor mediated disorders.
摘要翻译： 本发明涉及一种制备波生坦的改进方法。 特别涉及制备基本上不含式（II）的二聚物杂质和式（III）的6-羟基杂质的波生坦的方法。 本发明还涉及包含波生坦的药物组合物及其在治疗内皮素受体介导的病症中的用途。
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公开(公告)号：US08288401B2
公开(公告)日：2012-10-16
申请号：US12599108
申请日：2008-05-08
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D403/04
摘要： Novel polymorphic forms of bosentan and processes for their preparation are disclosed. Further, pharmaceutical compositions comprising said polymorphic forms and the use of said compositions in the treatment of patients suffering from endothelin receptor mediated disorders, for example, cardiovascular disorders such as hypertension, pulmonary hypertension, ischemia, vasospasm and angina pectoris are disclosed.
摘要翻译： 公开了波形坦的新型多晶型物及其制备方法。 此外，公开了包含所述多形态形式的药物组合物和所述组合物在治疗患有内皮素受体介导的病症的患者中的用途，例如心血管疾病如高血压，肺动脉高压，局部缺血，血管痉挛和心绞痛。
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公开(公告)号：US20110184071A1
公开(公告)日：2011-07-28
申请号：US12992464
申请日：2009-06-02
IPC分类号： A61K31/135 , C07C211/42 , C07C211/27 , A61P25/00
CPC分类号： C07C209/08 , C07C209/16 , C07C211/42 , C07C213/08 , C07C2602/08 , C07C211/27 , C07C217/20
摘要： The present invention relates to an improved process for the preparation of rasagiline (1) and its pharmaceutically acceptable salts. In particular it relates to a process for preparing rasagiline (1) and its salts substantially free from impurities.
摘要翻译： 本发明涉及制备雷沙吉兰（1）及其药学上可接受的盐的改进方法。 特别涉及制备雷沙吉兰（1）及其基本上不含杂质的盐的方法。
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公开(公告)号：US08569545B2
公开(公告)日：2013-10-29
申请号：US12992451
申请日：2009-06-02
IPC分类号： C07C211/42
CPC分类号： C07H1/06 , C07B2200/07 , C07C209/88 , C07C211/42 , C07C2602/08
摘要： The present invention relates to an improved process for the preparation of (R)-1-aminoindan (2), rasagiline (1) and pharmaceutically acceptable salts of rasagiline.
摘要翻译： 本发明涉及制备（R）-1-氨基茚满（2），雷沙吉兰（1）和雷沙吉兰药学上可接受的盐的改进方法。
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公开(公告)号：US08530488B2
公开(公告)日：2013-09-10
申请号：US12739303
申请日：2008-10-24
申请人： Abhay Gaitonde , Bindu Manojkumar , Sandeep Mekde , Prakash Bansode , Dattatraya Shinde , Sunanda Phadtare
发明人： Abhay Gaitonde , Bindu Manojkumar , Sandeep Mekde , Prakash Bansode , Dattatraya Shinde , Sunanda Phadtare
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D239/69
摘要： The present invention relates to novel crystalline forms of bosentan and processes for their preparation. Further, the invention relates to pharmaceutical compositions comprising said crystalline forms and use of said compositions in the treatment of patients suffering from endothelin receptor mediated disorders, for example, cardiovascular disorders such as hypertension, pulmonary hypertension, ischemia, vasospasm and angina pectoris.
摘要翻译： 本发明涉及新生的波生坦结晶形式及其制备方法。 此外，本发明涉及包含所述结晶形式的药物组合物和所述组合物用于治疗患有内皮素受体介导的病症的患者，例如心血管疾病如高血压，肺动脉高压，局部缺血，血管痉挛和心绞痛。
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公开(公告)号：US20130172369A1
公开(公告)日：2013-07-04
申请号：US13700845
申请日：2011-05-31
IPC分类号： C07D487/04
CPC分类号： A61K31/519 , C07D487/04
摘要： The present invention relates to the active pharmaceutical ingredient dipyridamole. In particular, it relates to efficient processes for the preparation of dipyridamole which are amenable to large scale commercial production and provide the required product with improved yield and purity. The present invention also relates to a novel crystallization method for the purification of dipyridamole.
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公开(公告)号：US20110263719A1
公开(公告)日：2011-10-27
申请号：US13056012
申请日：2009-07-29
IPC分类号： A61K31/135 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/00 , C07C211/42 , A61P25/28
CPC分类号： C07C211/42 , C07B2200/13 , C07C309/04 , C07C2602/08
摘要： The present invention relates to a novel crystalline form of rasagiline mesylate and a pure form of rasagiline mesylate and processes for their preparation. Further, the invention relates to pharmaceutical compositions comprising said forms and use of said compositions in the treatment of patients suffering from Parkinson's Disease, dementia, Alzheimer's Disease, depression, hyperactive syndrome, stroke, brain ischemia, neurotrauma, schizophrenia and multiple sclerosis.
摘要翻译： 本发明涉及甲磺酸雷沙吉兰的新型结晶形式和甲磺酸雷沙吉兰的纯形式及其制备方法。 此外，本发明涉及包含所述形式的所述形式的药物组合物和所述组合物在治疗患有帕金森病，痴呆，阿尔茨海默氏病，抑郁症，多动症综合征，中风，脑缺血，神经营养不良，精神分裂症和多发性硬化症的患者中的用途。
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公开(公告)号：US20110251288A1
公开(公告)日：2011-10-13
申请号：US12992451
申请日：2009-06-02
IPC分类号： A61K31/135 , C07C211/42 , A61P25/16 , A61P9/10 , A61P25/24 , A61P25/18 , A61P25/00 , C07H15/04 , A61P25/28
CPC分类号： C07H1/06 , C07B2200/07 , C07C209/88 , C07C211/42 , C07C2602/08
摘要： The present invention relates to an improved process for the preparation of (R)-1-aminoindan (2), rasagiline (1) and pharmaceutically acceptable salts of rasagiline.
摘要翻译： 本发明涉及制备（R）-1-氨基茚满（2），雷沙吉兰（1）和雷沙吉兰药学上可接受的盐的改进方法。
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公开(公告)号：US20100261742A1
公开(公告)日：2010-10-14
申请号：US12599108
申请日：2008-05-08
IPC分类号： A61K31/506 , C07D403/04 , A61P9/12 , A61P9/10
CPC分类号： C07D403/04
摘要： Novel polymorphic forms of bosentan and processes for their preparation are disclosed. Further, pharmaceutical compositions comprising said polymorphic forms and the use of said compositions in the treatment of patients suffering from endothelin receptor mediated disorders, for example, cardiovascular disorders such as hypertension, pulmonary hypertension, ischemia, vasospasm and angina pectoris are disclosed.
摘要翻译： 公开了波形坦的新型多晶型物及其制备方法。 此外，公开了包含所述多形态形式的药物组合物和所述组合物在治疗患有内皮素受体介导的病症的患者中的用途，例如心血管疾病如高血压，肺动脉高压，局部缺血，血管痉挛和心绞痛。
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