公开(公告)号：US11795136B2

公开(公告)日：2023-10-24

申请号：US16934715

申请日：2020-07-21

Applicant: Acucela Inc.

Inventor： Claes Olof Bavik ,  Susan Hayes Henry ,  Ryo Kubota ,  Vladimir A. Kuksa

IPC: C07C215/08 ,  A61K31/138 ,  A61K45/06 ,  A61K31/137 ,  C07C211/27 ,  C07C217/20 ,  C07C323/32 ,  C07D309/06 ,  A61K31/35 ,  A61K31/765

CPC classification number: C07C215/08 ,  A61K31/137 ,  A61K31/138 ,  A61K31/35 ,  A61K31/765 ,  A61K45/06 ,  C07C211/27 ,  C07C217/20 ,  C07C323/32 ,  C07D309/06

Abstract: Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.

公开(公告)号：US11708530B2

公开(公告)日：2023-07-25

申请号：US16758685

申请日：2018-10-30

Applicant: The Regents Of The University Of California

Inventor： Benjamin J. Stokes ,  Amir Keshavarz

IPC: C09K19/12 ,  C07C213/08 ,  C09K11/56 ,  C09K11/88 ,  C09K19/20 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00 ,  C07C217/20

CPC classification number: C09K19/12 ,  C07C213/08 ,  C09K11/565 ,  C09K11/883 ,  C09K19/20 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00 ,  C07C217/20 ,  C09K2019/123 ,  C09K2219/15

Abstract: Organic ligands and methods for preparing a variety of organic ligands are provided. The subject methods provide for the preparation of organic ligands in high yield and purity for use as ligands for attachment to nanoparticles to enable the formation of three dimensional nanocapsules of stably associated organic ligand-functionalized nanoparticles. Compositions that include these nanocapsules, as well as methods of making the nanocapsules are also provided.

公开(公告)号：US20230183167A1

公开(公告)日：2023-06-15

申请号：US17926216

申请日：2021-05-18

Applicant: Bowling Green State University

Inventor： Jayaraman Sivaguru ,  Ravichandranath Singathi ,  Sruthy Baburaj

IPC: C07C217/20 ,  C07C255/56 ,  C07C323/22 ,  C08F20/14 ,  C07D303/23 ,  C07F7/08 ,  C08F2/50

CPC classification number: C07C217/20 ,  C07C255/56 ,  C07C323/22 ,  C08F20/14 ,  C07D303/23 ,  C07F7/081 ,  C08F2/50

Abstract: Biomass derived benzoin derivatives, and methods of making and using the same, are described. Benzoin derivatives may be used as visible light photoinitiators.

公开(公告)号：US20170057970A1

公开(公告)日：2017-03-02

申请号：US15348756

申请日：2016-11-10

Applicant: David G. Whitten ,  Kirk S. Schanze ,  Anand Parthasarathy ,  Eunkyung Ji ,  Motokatsu Ogawa ,  Thomas S. Corbitt ,  Dimitri Dascier ,  Ying Wang ,  Linnea K. Ista ,  Eric H. Hill

Inventor： David G. Whitten ,  Kirk S. Schanze ,  Anand Parthasarathy ,  Eunkyung Ji ,  Motokatsu Ogawa ,  Thomas S. Corbitt ,  Dimitri Dascier ,  Ying Wang ,  Linnea K. Ista ,  Eric H. Hill

IPC: C07D487/08 ,  C08G61/02 ,  C08G61/12 ,  C07C217/20

CPC classification number: A01N43/90 ,  A01N25/08 ,  A01N25/10 ,  A01N33/10 ,  A01N33/12 ,  A01N41/04 ,  A01N43/10 ,  C07C217/14 ,  C07C217/20 ,  C07C309/11 ,  C07C309/24 ,  C07D333/16 ,  C07D409/14 ,  C07D487/08 ,  C08G61/02 ,  C08G61/126 ,  C08G75/00 ,  C08G2261/312 ,  C08G2261/3223 ,  C08G2261/3328 ,  C08G2261/3422 ,  C08G2261/93 ,  Y10T442/30

Abstract: The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.

Abstract translation: 本公开提供了新的聚（亚苯基亚乙炔基）（PPE）化合物，合成这些化合物的方法，以及掺入这些化合物的材料和物质。 各种PPE显示抗菌，抗病毒和抗真菌活性。

公开(公告)号：US20150368187A1

公开(公告)日：2015-12-24

申请号：US13634368

申请日：2011-03-07

Applicant: Ramachandran Murali ,  Mark I Greene

Inventor： Ramachandran Murali ,  Mark I Greene

IPC: C07C233/25 ,  C07C217/32

CPC classification number: C07C233/25 ,  A61K31/075 ,  C07C217/18 ,  C07C217/20 ,  C07C217/32 ,  C07C233/18

Abstract: The present invention relates to compounds of formula (I) that are inhibitors of tumor necrosis factor receptor I, compositions comprising such compounds, and methods of using such compounds and compositions thereof in the treatment of TNF-α mediated conditions: Formula (I)

Abstract translation: 本发明涉及作为肿瘤坏死因子受体I抑制剂的式（I）化合物，包含这些化合物的组合物，以及使用这些化合物及其组合物治疗TNF-α介导的病症的方法：式（I）

公开(公告)号：US20150321993A1

公开(公告)日：2015-11-12

申请号：US14423319

申请日：2013-08-22

Applicant: EMISPHERE TECHNOLOGIES, INC.

Inventor： Gabriela Mustata ,  Dahua Pan ,  David Gschneidner

IPC: C07C217/62 ,  A61K9/00 ,  A61K31/575 ,  A61K47/18

CPC classification number: C07C217/62 ,  A61K9/0053 ,  A61K9/2004 ,  A61K31/575 ,  A61K47/18 ,  C07C217/20

Abstract: The present invention relates to particular phenoxy alkyl diethanolamine and diisopropanolamine compounds for delivering biologically active agents to a target. These compounds are well suited for forming non-covalent mixtures with active agents for oral, intracolonic, pulmonary, and other routes of administration to animals.

Abstract translation: 本发明涉及特定的苯氧基烷基二乙醇胺和用于将生物活性剂递送至靶的二异丙醇胺化合物。 这些化合物非常适用于与动物口服，海洛因，肺和其他途径的活性剂形成非共价混合物。

公开(公告)号：US20150239825A1

公开(公告)日：2015-08-27

申请号：US14631763

申请日：2015-02-25

Applicant: Acucela Inc.

Inventor： Ian L. Scott ,  Vladimir A. Kuksa ,  Mark W. Orme ,  Thomas L. Little, JR. ,  Anna Gall ,  Feng Hong

IPC: C07C217/20

CPC classification number: A61K31/137 ,  A61K31/165 ,  A61K31/222 ,  C07C215/20 ,  C07C217/20 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C217/84 ,  C07C225/16 ,  C07C229/38 ,  C07C233/18 ,  C07C235/08 ,  C07C251/86 ,  C07C279/08 ,  C07C309/06 ,  C07C317/28 ,  C07C323/25 ,  C07C323/33 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/42 ,  C07D277/24 ,  C07D309/06

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Abstract translation: 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。 本文提供的是烷氧基衍生物化合物和包含这些化合物的药物组合物。 主题组合物可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。

公开(公告)号：US20150141417A9

公开(公告)日：2015-05-21

申请号：US13470779

申请日：2012-05-14

Applicant: Qingqi Chen ,  Rocio Alejandra Lopez ,  Jonathan Daniel Heller ,  Amanda Jean Morris

Inventor： Qingqi Chen ,  Rocio Alejandra Lopez ,  Jonathan Daniel Heller ,  Amanda Jean Morris

IPC: C07D307/54 ,  A61K31/09 ,  C07D277/24 ,  A61K31/427 ,  C07C217/20 ,  A61K31/138 ,  C07C43/23 ,  C07C43/225 ,  A61K31/5377 ,  A61K31/496 ,  C07C271/52 ,  A61K31/27 ,  C07D295/13 ,  C07D307/52 ,  A61K31/341 ,  A61P31/12 ,  A61P35/00 ,  A61P29/00 ,  A61P3/00 ,  A61P9/00 ,  C07D211/14 ,  C07C217/64 ,  A61K31/4545 ,  C07D295/15 ,  C07D295/088

CPC classification number: A61K31/5377 ,  A61K31/09 ,  A61K31/138 ,  A61K31/325 ,  A61K31/341 ,  A61K31/427 ,  A61K31/4545 ,  A61K31/496 ,  C07C43/225 ,  C07C43/23 ,  C07C217/20 ,  C07C217/64 ,  C07C271/52 ,  C07C2601/16 ,  C07D211/14 ,  C07D277/24 ,  C07D295/088 ,  C07D295/13 ,  C07D295/15 ,  C07D307/52 ,  C07D307/54

Abstract: Disclosed are nordihydroguaiaretic acid derivative compounds including various end groups bonded by a carbon atom or heteroatom though a side chain bonded to the respective hydroxy residue O groups by an ether bond or a carbamate bond, pharmaceutical compositions, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, a metabolic disease, such as diabetes, a vascular disease, such as hypertension and macular degeneration, or a proliferative disease, such as diverse types of cancers.

Abstract translation: 公开了包括通过碳原子或杂原子键合的各种端基的二脱氢愈创木酸衍生物化合物，其中通过醚键或氨基甲酸酯键与各羟基残基O基键合的侧链，药物组合物，制备方法和使用方法 它们和试剂盒包括它们用于治疗疾病和病症，特别是由HIV感染，HIV感染或HSV感染引起的或与之相关的疾病，诸如各种类型的关节炎和炎性疾病 肠疾病，代谢疾病如糖尿病，血管疾病如高血压和黄斑变性，或增生性疾病，如多种类型的癌症。

公开(公告)号：US09000216B2

公开(公告)日：2015-04-07

申请号：US14002574

申请日：2012-03-06

Applicant: Kazuaki Ishihara ,  Muhammet Uyanik ,  Takeshi Yasui

Inventor： Kazuaki Ishihara ,  Muhammet Uyanik ,  Takeshi Yasui

IPC: C07D307/94 ,  C07D491/107 ,  C07D317/72 ,  C07C217/20 ,  C07C311/17 ,  C07C233/69 ,  C07C233/70 ,  C07C271/16 ,  B01J31/02 ,  C07C235/48

CPC classification number: B01J31/0209 ,  C07C217/20 ,  C07C233/69 ,  C07C233/70 ,  C07C235/48 ,  C07C271/16 ,  C07C311/17 ,  C07D307/94 ,  C07D317/72 ,  C07D491/107

Abstract: An optically active spirolactone compound is highly enantioselectively produced by using an iodoarene derivative which can be synthesized easily and which is not racemized easily. A hypervalent iodine compound precursor (iodoarene derivative) which was able to be designed flexibly was synthesized from 2,6-dihydroxyiodoarene by using 1,2-aminoalcohol as a chiral source in short steps, a hypervalent iodine compound was prepared in a reaction system (in situ) by using a catalyst quantity of the resulting precursor in the presence of a stoichiometric quantity of m-CPBA, and a spirolactonization reaction of 3-(1-hydroxy-2-naphthyl)propionic acid was induced. As a result, a corresponding spirolactone compound was obtained at a high enantiomeric excess.

Abstract translation: 通过使用可以容易地合成并且不容易外消旋化的碘代芳烃衍生物，高度对映选择性地制备光学活性的己内酯化合物。 通过使用1,2-氨基醇作为手性来源，通过短时间步骤，可以从2,6-二羟基碘代芳烃合成出能够灵活设计的高价碘化合物前体（碘代芳烃衍生物），在反应体系中制备了高价碘化合物 通过在化学计量的m-CPBA的存在下使用所得前体的催化剂量，并引发3-（1-羟基-2-萘基）丙酸的反式己内酯化反应。 结果，以高对映体过量获得相应的己内酯化合物。

公开(公告)号：US08993807B2

公开(公告)日：2015-03-31

申请号：US13291932

申请日：2011-11-08

Applicant: Ian L. Scott ,  Vladimir A. Kuksa ,  Mark W. Orme ,  Thomas Little ,  Anna Gall ,  Feng Hong

Inventor： Ian L. Scott ,  Vladimir A. Kuksa ,  Mark W. Orme ,  Thomas Little ,  Anna Gall ,  Feng Hong

IPC: C09B11/02 ,  C07C211/00 ,  A01N33/02 ,  A61K31/135 ,  C07C215/20 ,  C07C217/20 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C225/16 ,  C07C229/38 ,  C07C233/18 ,  C07C235/08 ,  C07C251/86 ,  C07C279/08 ,  C07C317/28 ,  C07C323/25 ,  C07D277/24 ,  C07D309/06

CPC classification number: A61K31/137 ,  A61K31/165 ,  A61K31/222 ,  C07C215/20 ,  C07C217/20 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C217/84 ,  C07C225/16 ,  C07C229/38 ,  C07C233/18 ,  C07C235/08 ,  C07C251/86 ,  C07C279/08 ,  C07C309/06 ,  C07C317/28 ,  C07C323/25 ,  C07C323/33 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/42 ,  C07D277/24 ,  C07D309/06

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.