公开(公告)号：US20060287286A1

公开(公告)日：2006-12-21

申请号：US11426661

申请日：2006-06-27

Applicant: Keith BIGGADIKE ,  Diane Coe ,  Dean Edney ,  Stephen Guntrip ,  Abigail Halton ,  Brian Looker ,  Michael Monteith ,  Rebecca Moore ,  Rajnikant Patel ,  Panayiotis Procopiou

Inventor： Keith BIGGADIKE ,  Diane Coe ,  Dean Edney ,  Stephen Guntrip ,  Abigail Halton ,  Brian Looker ,  Michael Monteith ,  Rebecca Moore ,  Rajnikant Patel ,  Panayiotis Procopiou

IPC: A61K31/573 ,  A61K31/18

CPC classification number: C07D295/26 ,  C07C311/27 ,  C07C311/29 ,  C07C311/58 ,  C07C2601/04 ,  C07C2601/14 ,  C07D295/13

Abstract: The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

Abstract translation: 本发明涉及式（I）的新化合物，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是其在预防和治疗呼吸系统疾病中的用途。

公开(公告)号：US20050163720A1

公开(公告)日：2005-07-28

申请号：US10504252

申请日：2003-02-12

Applicant: Brian Looker ,  Christopher Lunniss ,  Alison Redgrave

Inventor： Brian Looker ,  Christopher Lunniss ,  Alison Redgrave

IPC: A61K9/12 ,  A61K20060101 ,  A61K8/60 ,  A61K8/81 ,  A61K8/92 ,  A61K9/00 ,  A61K47/12 ,  A61K47/14 ,  A61P11/00 ,  A61Q9/04 ,  B01F20060101 ,  C07C20060101 ,  C07C69/63 ,  C09K3/00 ,  A61K31/225 ,  A61L9/04

CPC classification number: A61K8/60 ,  A61K8/8111 ,  A61K8/922 ,  A61K9/008 ,  A61K47/12 ,  A61Q9/04 ,  C07C69/63

Abstract: Compounds of formula (I) or a salt or solvate thereof, wherein: x represents 0 or 1; y represents 0 or 1; R1 and R2 independently represent —C1-9 alkyleneC1-6 fluoroalkyl, which fluoroalkyl moiety contains at least 1 fluorine atom and not more than 3 consecutive perfluorocarbon atoms and wherein the R1 and/or R2 moiety is optionally interrupted by an ether link, processes for their preparation, use of the compounds in the preparation of pharmaceutical formulations and the formulations are described.

Abstract translation: 式（I）化合物或其盐或溶剂合物，其中：x表示0或1; y表示0或1; R 1和R 2独立地代表-C 1-6 - 亚烷基C 1-6 - 氟代烷基，该氟烷基部分含有 至少1个氟原子和不超过3个连续的全氟化碳原子，其中R 1和/或R 2 O 2部分任选地被醚键中断，其制备方法 描述了制备药物制剂和制剂中化合物的用途。