公开(公告)号：US20060111344A1

公开(公告)日：2006-05-25

申请号：US10522321

申请日：2003-07-24

Applicant: Keith Biggadike ,  Diane Coe ,  Duncan Holmes ,  Brian Looker

Inventor： Keith Biggadike ,  Diane Coe ,  Duncan Holmes ,  Brian Looker

IPC: A61K31/549 ,  A61K31/538 ,  A61K31/4704 ,  A61K31/405 ,  A61K31/428 ,  A61K31/325 ,  A61K31/138 ,  A61K31/165

CPC classification number: C07D277/68 ,  C07C311/29 ,  C07D213/65 ,  C07D215/26 ,  C07D265/36

Abstract: The present invention relates to compounds of formula (I) as defined herein and salts or solvates thereof. Processes for preparing these compounds and pharmaceutical formulations containing them are also disclosed, as well as methods for the prophylaxis of treatment of a clinical condition using such compounds.

Abstract translation: 本发明涉及本文定义的式（I）化合物及其盐或溶剂化物。 还公开了制备这些化合物的方法和含有它们的药物制剂的方法，以及用于预防使用这些化合物治疗临床病症的方法。

公开(公告)号：US20050256201A1

公开(公告)日：2005-11-17

申请号：US10512232

申请日：2003-04-24

Applicant: Philip Box ,  Diane Coe ,  Brian Looker ,  Panayiotis Procopiou

Inventor： Philip Box ,  Diane Coe ,  Brian Looker ,  Panayiotis Procopiou

IPC: C07D307/68 ,  A61K31/137 ,  A61K31/166 ,  A61K31/167 ,  A61K31/17 ,  A61K31/18 ,  A61K31/192 ,  A61K31/341 ,  A61K31/455 ,  A61P1/04 ,  A61P9/00 ,  A61P11/00 ,  A61P11/06 ,  A61P11/08 ,  A61P15/06 ,  A61P17/00 ,  A61P17/06 ,  A61P21/00 ,  A61P25/02 ,  A61P25/24 ,  A61P27/16 ,  A61P43/00 ,  C07C217/56 ,  C07C217/60 ,  C07C219/28 ,  C07C233/25 ,  C07C235/42 ,  C07C255/54 ,  C07C275/32 ,  C07C275/40 ,  C07C279/18 ,  C07C307/06 ,  C07C307/10 ,  C07C311/04 ,  C07C311/08 ,  C07C311/29 ,  C07C313/06 ,  C07C317/22 ,  C07D213/82 ,  C07F7/18 ,  A61K31/16 ,  A61K31/138 ,  C07C217/64

CPC classification number: C07C275/32 ,  C07C217/60 ,  C07C233/25 ,  C07C235/42 ,  C07C255/54 ,  C07C279/18 ,  C07C307/10 ,  C07C311/08 ,  C07C311/29 ,  C07C317/22 ,  C07C2601/08 ,  C07C2601/14

Abstract: The present invention relates to novel compounds of formula (I), or a salt, solvate, or physiologically functional derivative thereof, to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

Abstract translation: 本发明涉及新的式（I）化合物或其盐，溶剂合物或生理功能衍生物，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是其用于 预防和治疗呼吸系统疾病。

公开(公告)号：US20050075394A1

公开(公告)日：2005-04-07

申请号：US10489569

申请日：2002-09-11

Applicant: Philip Box ,  Diane Coe ,  Brian Looker ,  Inderjit Mann ,  Panayiotis Procopiou

Inventor： Philip Box ,  Diane Coe ,  Brian Looker ,  Inderjit Mann ,  Panayiotis Procopiou

IPC: C07D213/56 ,  A61K31/17 ,  A61K31/18 ,  A61K31/222 ,  A61K31/44 ,  A61K31/455 ,  A61K45/00 ,  A61P1/04 ,  A61P9/04 ,  A61P11/00 ,  A61P11/06 ,  A61P15/00 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P21/00 ,  A61P25/24 ,  A61P37/08 ,  A61P43/00 ,  C07C213/02 ,  C07C213/08 ,  C07C217/08 ,  C07C217/76 ,  C07C233/75 ,  C07C237/42 ,  C07C271/38 ,  C07C275/32 ,  C07C275/40 ,  C07C311/08 ,  C07C311/21 ,  C07C311/29 ,  C07C317/14 ,  C07C317/22 ,  C07D213/82 ,  C07D239/54 ,  C07D333/70 ,  C07D413/12 ,  C07D513/04 ,  A61K31/325 ,  A61K31/195

CPC classification number: C07D213/82 ,  C07C217/08 ,  C07C217/76 ,  C07C233/75 ,  C07C237/42 ,  C07C271/38 ,  C07C275/32 ,  C07C275/40 ,  C07C311/08 ,  C07C311/21 ,  C07C311/29 ,  C07C317/14 ,  C07C317/22 ,  C07C2601/02 ,  C07C2601/08 ,  C07D239/54 ,  C07D333/70 ,  C07D513/04

Abstract: The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

公开(公告)号：US20060148771A1

公开(公告)日：2006-07-06

申请号：US10544869

申请日：2004-02-12

Applicant: Keith Biggadike ,  Philip Box ,  Diane Coe ,  Duncan Holmes ,  Brian Looker ,  Panayiotis Procopiou

Inventor： Keith Biggadike ,  Philip Box ,  Diane Coe ,  Duncan Holmes ,  Brian Looker ,  Panayiotis Procopiou

IPC: A61K31/58 ,  A61K31/538 ,  A61K31/4704 ,  A61K31/428 ,  A61K31/549 ,  A61K31/405 ,  A61K31/35 ,  A61K31/325 ,  A61K31/225 ,  A61K31/138

CPC classification number: C07D213/65 ,  C07C217/28

Abstract: A compound of formula (I) or a salt, solvate, or physiologically functional derivative thereof, wherein: m is an integer of from 2 to 8; n is an integer of from 2 to 5; with the proviso that m+n is 4 to 10; R4 and R5 are independently selected from hydrogen and C1-4alkyl with the proviso that the total number of carbon atoms in R4 and R5 is not more than 4; R6 and R7 are independently selected from hydrogen and C1-4alkyl with the proviso that the total number of carbon atoms in R6 and R7 is not more than 4, and Ar1 is a group selected from (a), (b), (c) and (d).

Abstract translation: 式（I）化合物或其盐，溶剂合物或生理功能衍生物，其中：m为2至8的整数; n为2〜5的整数， 条件是m + n为4至10; R 4和R 5独立地选自氢和C 1-4 - 烷基，条件是R 3中的碳原子总数 SUP> 4和R 5不超过4; R 6和R 7独立地选自氢和C 1-4 - 烷基，条件是R 1中的碳原子总数 SUP> 6和R 7不超过4，Ar 1是选自（a），（b），（c）和 （d）。

公开(公告)号：US20050287076A1

公开(公告)日：2005-12-29

申请号：US10506339

申请日：2003-03-04

Applicant: Brian Looker ,  Christopher Lunniss ,  Alison Redgrave

Inventor： Brian Looker ,  Christopher Lunniss ,  Alison Redgrave

IPC: A61K9/12 ,  A61K9/00 ,  A61K9/72 ,  A61K47/06 ,  A61K47/24 ,  C07F9/10 ,  C07F9/11 ,  A61K9/14 ,  C07F9/02

CPC classification number: A61K9/008 ,  C07F9/10

Abstract: Compounds of formula (I): and uses of such compounds are described.

Abstract translation: 描述了式（I）化合物及其用途。

公开(公告)号：US20080003290A1

公开(公告)日：2008-01-03

申请号：US11566346

申请日：2006-12-04

Applicant: Philip Box ,  Diane Coe ,  Brian Looker ,  Inderjit Mann ,  Panayiotis Procopiou

Inventor： Philip Box ,  Diane Coe ,  Brian Looker ,  Inderjit Mann ,  Panayiotis Procopiou

IPC: A61K31/42 ,  A61K9/14 ,  A61M15/00 ,  A61P11/00 ,  C07D413/00

CPC classification number: C07D213/82 ,  C07C217/08 ,  C07C217/76 ,  C07C233/75 ,  C07C237/42 ,  C07C271/38 ,  C07C275/32 ,  C07C275/40 ,  C07C311/08 ,  C07C311/21 ,  C07C311/29 ,  C07C317/14 ,  C07C317/22 ,  C07C2601/02 ,  C07C2601/08 ,  C07D239/54 ,  C07D333/70 ,  C07D513/04

Abstract: The present invention relates to novel compounds of formula (1), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory disease.

Abstract translation: 本发明涉及式（1）的新化合物，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是其在预防和治疗呼吸系统疾病中的用途。

公开(公告)号：US20070004807A1

公开(公告)日：2007-01-04

申请号：US11207967

申请日：2005-08-19

Applicant: Keith Biggadike ,  Diane Coe ,  Dean Edney ,  Stephen Guntrip ,  Abigai Halton ,  Brian Looker ,  Michael Monteith ,  Rebecca Moore ,  Rajnikant Patel ,  Panayiotis Procopiou

Inventor： Keith Biggadike ,  Diane Coe ,  Dean Edney ,  Stephen Guntrip ,  Abigai Halton ,  Brian Looker ,  Michael Monteith ,  Rebecca Moore ,  Rajnikant Patel ,  Panayiotis Procopiou

IPC: A61K31/18 ,  C07C311/35

CPC classification number: C07D295/26 ,  C07C311/27 ,  C07C311/29 ,  C07C311/58 ,  C07C2601/04 ,  C07C2601/14 ,  C07D295/13

Abstract: The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

Abstract translation: 本发明涉及式（I）的新化合物，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是其在预防和治疗呼吸系统疾病中的用途。

公开(公告)号：US20060287389A1

公开(公告)日：2006-12-21

申请号：US11426657

申请日：2006-06-27

Applicant: Keith BIGGADIKE ,  Diane Coe ,  Dean Edney ,  Stephen Guntrip ,  Abigail Halton ,  Brian Looker ,  Michael Monteith ,  Rebecca Moore ,  Rajnikant Patel ,  Panayiotis Procopiou

Inventor： Keith BIGGADIKE ,  Diane Coe ,  Dean Edney ,  Stephen Guntrip ,  Abigail Halton ,  Brian Looker ,  Michael Monteith ,  Rebecca Moore ,  Rajnikant Patel ,  Panayiotis Procopiou

IPC: C07C311/02 ,  A61K31/24 ,  A61K31/18 ,  A61K31/573

CPC classification number: C07D295/26 ,  C07C311/27 ,  C07C311/29 ,  C07C311/58 ,  C07C2601/04 ,  C07C2601/14 ,  C07D295/13

Abstract: The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

公开(公告)号：US20060205794A1

公开(公告)日：2006-09-14

申请号：US10532869

申请日：2003-10-24

Applicant: Alan Chapman ,  Stephen Guntrip ,  Brian Looker ,  Panayiotis Procopiou

Inventor： Alan Chapman ,  Stephen Guntrip ,  Brian Looker ,  Panayiotis Procopiou

IPC: A61K31/44 ,  A61K31/42 ,  A61K31/35 ,  A61K31/138 ,  A61K31/165

CPC classification number: C07D213/66 ,  C07C317/22 ,  C07C323/19 ,  C07C2601/08 ,  C07C2601/14 ,  C07D213/65 ,  C07D215/227 ,  C07D215/26 ,  C07D261/10 ,  C07D263/22 ,  C07D309/40 ,  C07D319/08

Abstract: The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

Abstract translation: 本发明涉及式（I）的新化合物，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是其在预防和治疗呼吸系统疾病中的用途。

公开(公告)号：US20050048024A1

公开(公告)日：2005-03-03

申请号：US10492606

申请日：2002-10-17

Applicant: Brian Looker ,  Christopher Lunniss ,  Alison Redgrave

Inventor： Brian Looker ,  Christopher Lunniss ,  Alison Redgrave

IPC: A61K9/12 ,  A61K9/00 ,  A61K9/72 ,  A61K31/137 ,  A61K31/439 ,  A61K31/522 ,  A61K31/56 ,  A61K31/573 ,  A61K31/58 ,  A61K47/06 ,  A61K47/12 ,  A61K47/34 ,  A61P11/02 ,  A61P11/06 ,  A61P11/08 ,  A61P29/00 ,  A61P37/08 ,  B01F17/00 ,  C07C59/125 ,  C07C59/185 ,  A61L9/04 ,  A61K7/075 ,  A61K7/08 ,  C07C59/10

CPC classification number: A61K9/008 ,  B01F17/0028 ,  B01F17/0035

Abstract: Compounds of formula (I): or salts or solvate thereof, wherein: n and N independently represent an integer 2 to 12; m1 and m2 independently represent an integer 1 to 15; and R1 and R2 independently represent —(CO)xC1-9 alkyl or —(CO)xC1-9 fluoroalkyl, which fluoroalkyl moiety contains at least 1 fluorine atom and not more than 3 consecutive perfluorocarbon atoms wherein x represents 0 or 1, as well as pharmaceutical formulations containing such compounds and processes for the manufacture of such compounds are disclosed. Intermediates of such compounds and processes for the manufacture of such intermediates are also disclosed.

Abstract translation: 式（I）化合物或其盐或溶剂合物，其中：n和n独立地表示2-12的整数; m 1和m 2独立地表示1至15的整数; 和R 1和R 2独立地表示 - （CO）x C1-9烷基或 - （CO）xC1-9氟代烷基，该氟烷基部分含有至少1个氟原子和不多于3个连续的全氟化碳原子，其中x表示 0或1，以及含有这些化合物的药物制剂和制备这些化合物的方法。 还公开了这些化合物的中间体和制备这种中间体的方法。