公开(公告)号：US20190100727A1

公开(公告)日：2019-04-04

申请号：US16147775

申请日：2018-09-30

申请人： Charite Universitatsmedizin Berlin

发明人： Marion Haag ,  Jochen Ringe ,  Michael Sittinger ,  Carsten Tschope

IPC分类号： C12N5/077 ,  G01N33/569 ,  A61K35/34

摘要： According to the invention fibroblast-like cells obtained from heart muscle biopsies, which are CD90 negative, CD105 positive, CD117 negative and/or CD166 positive as well as cell preparations of such cells for therapy of heart diseases as well as a method for providing the latter are disclosed. The cells according to the invention are characterized by a good cultivability in cell culture. Furthermore a method for obtaining the cells and cell preparations according to the invention are disclosed.

公开(公告)号：US09974895B2

公开(公告)日：2018-05-22

申请号：US14511329

申请日：2014-10-10

申请人： Gambro Lundia AB ,  Charite Universitatsmedizin Berlin

发明人： Markus Storr ,  Bernd Krause ,  Ralf Schindler ,  Daniel Zickler ,  Bjoern Hegner

IPC分类号： A61M37/00 ,  A61M1/16 ,  A61K35/14 ,  B01D63/02 ,  B01D69/08 ,  B01D69/14 ,  B01D71/68 ,  B01D61/24

CPC分类号： A61M1/16 ,  A61K35/14 ,  A61M2202/0014 ,  B01D61/243 ,  B01D63/021 ,  B01D69/08 ,  B01D69/141 ,  B01D71/68 ,  B01D2325/38

摘要： The present disclosure relates to a hemodialysis membrane for the treatment of vascular calcification in hemodialysis patients, especially in chronic hemodialysis patients. The present disclosure further relates to methods of treating vascular calcification in hemodialysis patients, wherein the hemodialysis membrane is characterized in that it comprises at least one hydrophobic polymer and at least one hydrophilic polymer and in that it has a MWRO of between 15 and 20 kD and a MWCO of between 170-320 kD or that the hemodialysis membrane comprises at least one hydrophobic polymer and at least one hydrophilic polymer and has a MWRO of between 8.5 kD and 14.0 kD and a MWCO of between 55 kD and 130 kD.

公开(公告)号：US20160207994A1

公开(公告)日：2016-07-21

申请号：US15000063

申请日：2016-01-19

申请人： UNIVERSITAT ZURICH ,  CHARITE UNIVERSITATSMEDIZIN BERLIN

发明人： Burkhard Becher ,  Frank Heppner

IPC分类号： C07K16/24 ,  G01N33/50 ,  A61K31/5377 ,  A61K31/202 ,  A61K38/17 ,  C12N15/113

CPC分类号： C07K16/244 ,  A61K31/202 ,  A61K31/5377 ,  A61K38/1793 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/92 ,  C12N15/1136 ,  C12N2310/14 ,  C12N2320/30 ,  G01N33/502 ,  G01N33/5058

摘要： The invention provides antibody against p40, IL-12 or IL-23 for the prevention or treatment of Alzheimer's disease. It further provides ligands to the pair of interleukin 12 or 23 and its specific receptor, specifically an antibody, an antibody fragment, an antibody-like-molecule, for the prevention or treatment of Alzheimer's disease. Similarly, siRNA, antisense or transcription factor modulators of gene expression of p19, p35, p40, IL-12R-β1, IL-12R-β2, and/or IL-23R for the prevention or treatment of Alzheimer's disease are provided.

摘要翻译： 本发明提供了抗p40，IL-12或IL-23的抗体，用于预防或治疗阿尔茨海默氏病。 它进一步提供了一对白介素12或23及其特异性受体，特别是抗体，抗体片段，抗体样分子，用于预防或治疗阿尔茨海默氏病的配体。 类似地，用于预防或治疗阿尔茨海默氏病的p19，p35，p40，IL-12R-＆bgr; 1，IL-12R-和bgr2和/或IL-23R的基因表达的siRNA，反义或转录因子调节剂是 提供。

公开(公告)号：US20150329624A1

公开(公告)日：2015-11-19

申请号：US14727152

申请日：2015-06-01

申请人： CHARITE - UNIVERSITATSMEDIZIN BERLIN

发明人： Karl SKRINER

IPC分类号： C07K16/18

CPC分类号： C07K16/18 ,  A61K39/39575 ,  C07K16/16 ,  C07K2317/11 ,  C07K2317/23 ,  C07K2317/55 ,  C07K2317/70 ,  C07K2317/76

摘要： The present invention relates to an IgY composition characterized in that said IgY composition contains IgY antibodies, fragments, and/or Fab fragments thereof that specifically bind to a peptide with the amino acid sequence of SEQ ID NO: 1 and to the use of this IgY composition in the therapy of celiac disease, rheumatism, and/or wheat allergy.

摘要翻译： 本发明涉及IgY组合物，其特征在于所述IgY组合物含有与SEQ ID NO：1的氨基酸序列特异性结合肽的IgY抗体，片段和/或Fab片段，以及该IgY的使用 治疗乳糜泻，风湿病和/或小麦过敏的组合物。

公开(公告)号：US20140302045A1

公开(公告)日：2014-10-09

申请号：US14225882

申请日：2014-03-26

申请人： CHARITE - UNIVERSITATSMEDIZIN BERLIN

发明人： Karl SKRINER

IPC分类号： C07K16/16 ,  A61K39/395

CPC分类号： C07K16/18 ,  A61K39/39575 ,  C07K16/16 ,  C07K2317/11 ,  C07K2317/23 ,  C07K2317/55 ,  C07K2317/70 ,  C07K2317/76

摘要： The present invention relates to an IgY composition characterized in that said IgY composition contains IgY antibodies, fragments, and/or Fab fragments thereof that specifically bind to a peptide with the amino acid sequence of SEQ ID NO: 1 and to the use of this IgY composition in the therapy of celiac disease, rheumatism, and/or wheat allergy.

摘要翻译： 本发明涉及IgY组合物，其特征在于所述IgY组合物含有与SEQ ID NO：1的氨基酸序列特异性结合肽的IgY抗体，片段和/或Fab片段，以及该IgY的使用 治疗乳糜泻，风湿病和/或小麦过敏的组合物。