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公开(公告)号：US20240353396A1
公开(公告)日：2024-10-24
申请号：US18653887
申请日：2024-05-02
Applicant: Brown University
Inventor： Gregorio Valdez
IPC: G01N33/50 , G01N15/01 , G01N15/1434 , G01N15/149 , G01N33/68
CPC classification number: G01N33/5058 , G01N15/1434 , G01N33/68 , G01N15/01 , G01N15/149 , G01N2333/43595 , G01N2333/705
Abstract: The invention provides molecular tools to visualize, isolate, and manipulate the glial cells that are necessary for the formation, stability, and function of the synapse. The inventors identified a unique gene expression signature that distinguishes perisynaptic Schwann cells from all other Schwann cells. Using a combinatorial approach and coëxpressing two different fluorescence proteins, each using a different promoter, only those glial cells associated with the neuromuscular synapse are labeled.
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公开(公告)号：US12068059B2
公开(公告)日：2024-08-20
申请号：US16481061
申请日：2018-01-25
Inventor： Vikram Khurana , Chee Yeun Chung , Susan Lindquist , Bonnie A. Berger , Ernest Fraenkel , Jian Peng
CPC classification number: G16B5/00 , C12Q1/025 , G01N33/5058 , G16B25/00 , G16B30/10 , G01N2500/10
Abstract: Disclosed are methods, systems, cells and compositions directed to modeling a physiologic or pathologic process in an animal using a set of yeast genes analogous to a set of animal genes and augmenting the physiologic or pathologic process in the animal with predicted gene interactions based on the interactions between the set of yeast genes. Also disclosed are methods of screening for and using therapeutics for neurodegenerative proteinopathies.
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公开(公告)号：US20240219375A1
公开(公告)日：2024-07-04
申请号：US18554103
申请日：2022-04-07
Applicant: FUJIFILM Cellular Dynamics, Inc.
Inventor： Christopher McMAHON , Randall LEARISH , Carrie CHAVEZ , Cayla THOMPSON
IPC: G01N33/50 , C12N5/0793
CPC classification number: G01N33/5058 , C12N5/0619 , G01N33/502 , C12N2501/119 , C12N2501/13 , C12N2501/15 , C12N2501/41 , C12N2501/415 , C12N2506/45 , G01N2500/10
Abstract: Midbrain dopaminergic neuronal precursor cells that can be used to treat a brain disorder are provided herein. Improved mono-SMAD methods are provided that can be used to differentiate pluripotent cells into midbrain dopaminergic (DA) neurons or midbrain neuronal precursors. In some aspects, methods are provided for mono-SMAD culture protocols and culture durations that can be used to generate dopaminergic neuronal precursor cells that have significantly improved properties for the treatment of a brain disorder such as, e.g., Parkinson's disease. Methods of treating Parkinson's disease and other brain diseases with the midbrain dopaminergic neuronal precursor cells are also provided.
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公开(公告)号：US11970522B2
公开(公告)日：2024-04-30
申请号：US17006219
申请日：2020-08-28
Applicant: The University of British Columbia
Inventor： Neil R. Cashman , Steven S. Plotkin
IPC: C07K7/00 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/12 , A61K38/17 , A61K39/00 , A61K47/64 , A61K51/10 , A61P25/28 , C07K5/113 , C07K5/117 , C07K7/64 , C07K14/00 , C07K14/47 , C07K16/18 , G01N33/68 , A61K38/05 , A61K38/07 , A61K39/385 , A61K39/39 , A61K39/395 , A61K45/00 , A61K45/06 , A61K47/68 , A61K47/69 , A61K49/18 , A61K51/08 , A61L27/22 , A61L27/34 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , C07K5/103 , C07K7/06 , C07K7/08 , C07K14/435 , C07K16/00 , G01N33/50
CPC classification number: C07K14/4711 , A61K39/0008 , A61K47/643 , A61K47/646 , A61K51/1018 , A61P25/28 , C07K5/1021 , C07K5/1024 , C07K7/64 , C07K16/18 , G01N33/6896 , A61K38/00 , A61K38/05 , A61K38/07 , A61K38/08 , A61K38/12 , A61K39/00 , A61K39/0007 , A61K39/385 , A61K39/39 , A61K39/395 , A61K39/39533 , A61K39/3955 , A61K2039/505 , A61K2039/55505 , A61K2039/6081 , A61K45/05 , A61K45/06 , A61K47/6803 , A61K47/6921 , A61K49/1818 , A61K51/088 , A61K51/10 , A61K2300/00 , A61L27/227 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , C07K5/101 , C07K7/06 , C07K7/08 , C07K14/435 , C07K16/00 , C07K2317/20 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/524 , C07K2317/526 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/624 , C07K2317/626 , C07K2317/70 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00 , G01N33/5058 , G01N2333/4709 , G01N2800/28 , G01N2800/2821 , G01N2800/387
Abstract: The disclosure pertains to epitopes identified in A-beta including conformational epitopes, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.
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公开(公告)号：US20240085402A1
公开(公告)日：2024-03-14
申请号：US18491513
申请日：2023-10-20
Applicant: Hoffmann-La Roche Inc.
Inventor： Veronica COSTA , Maj HEDTJÄRN , Marius HOENER , Ravi JAGASIA , Mads Aaboe JENSEN , Christoph PATSCH , Lykke PEDERSEN , Søren Vestergaard RASMUSSEN
IPC: G01N33/50 , C12N5/00 , C12N5/074 , C12N5/0793 , C12N5/0797 , C12N15/11 , C12N15/113
CPC classification number: G01N33/5014 , C12N5/0018 , C12N5/0619 , C12N5/0623 , C12N5/0696 , C12N15/11 , C12N15/111 , C12N15/113 , C12N15/1137 , G01N33/5058 , C12N2310/11 , C12N2310/20 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/33 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2320/34 , C12N2500/38 , C12N2500/44 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/13 , C12N2501/41 , C12N2501/60 , C12N2501/727 , C12N2501/999 , C12N2503/02 , C12N2506/45 , C12N2533/52
Abstract: The present invention relates to oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA downstream of SNORD109B. The present invention further relates to pharmaceutical compositions and methods for treatment of Angelman syndrome.
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Patent Agency Ranking
公开(公告)号：US20240077470A1
公开(公告)日：2024-03-07
申请号：US18502728
申请日：2023-11-06
Applicant: HUGEL INC.
Inventor： Chee Gun LEE , Ji Hyun Oum , Vijayajumar Ajay , Xiangai Gui
CPC classification number: G01N33/5058 , C07K16/1282 , C12N5/0618 , G01N33/5014 , C07K2317/565 , C12N2500/32 , C12N2500/36
Abstract: A new cell line and an antibody for determining the activity of botulinum toxin are disclosed. Also disclosed is a method of determining the activity of botulinum toxin using the cell line and/or the antibody.
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公开(公告)号：US20240043799A1
公开(公告)日：2024-02-08
申请号：US18234995
申请日：2023-08-17
Inventor： Wassim Elyaman , Elizabeth M. Bradshaw
CPC classification number: C12N5/0622 , G01N33/5058 , G01N2800/52 , C12N2506/115 , C12N2502/081
Abstract: Provided herein are methods and compositions related to the use of human monocyte-derived microglia-like (MDMi) cells. In some embodiments, the methods and compositions provided herein relate to the use of MDMi cells to assess the effect of a clinical intervention on a human subject (e.g., a subject with a neurodegenerative disorder). In some embodiments, the methods and compositions provided herein relate to the use of MDMi cells to stratify human subjects into subgroup populations (e.g., populations that are likely to respond to a clinical intervention or are unlikely to respond to a clinical intervention). In some embodiments, the methods and compositions provided herein relate to the use of MDMi cells to identify candidate neurodegenerative disease biomarkers. In certain embodiments, the methods and compositions provided herein relate to the use of MDMi cells to screen potential therapeutic agents to identify candidate agents for the treatment of a neurodegenerative disease.
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公开(公告)号：US20240043483A1
公开(公告)日：2024-02-08
申请号：US18266712
申请日：2021-12-21
Inventor： Marc DIAMOND , Victor MANON , Jaime VAQUER-ALICEA , Brian HITT
CPC classification number: C07K14/4711 , C12N15/63 , G01N33/6896 , G01N33/5058
Abstract: The present disclosure provides biosensor cells and methods of use thereof. The disclosure provides, for example, methods of measuring a titer of or of detecting a seed tau protein in a sample, methods of detecting Alzheimer's disease (AD), or a neurodegenerative tauopathy disease or condition linked to tau protein aggregation, and methods for the identification of putative tau protein aggregation inhibitors or modulators.
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公开(公告)号：US20240003871A1
公开(公告)日：2024-01-04
申请号：US18344703
申请日：2023-06-29
Inventor： Deepika RAJESH , Christie MUNN , Sarah BURTON , Ali FATHI , Rachel LEWIS , Robert BRADLEY , Jing LIU
CPC classification number: G01N33/5058 , C12N5/0622 , C12N2506/45 , C12N2501/235 , C12N2500/90 , C12N2501/727 , C12N2533/90 , C12N2513/00 , C12N2501/13 , C12N2501/11 , C12N2501/25 , C12N2501/2301
Abstract: The present disclosure provides method for producing neural precursor cells with a glial bias from induced pluripotent cells and further differentiating the neural precursor cells to astrocytes. Further provided herein are methods for the use of the astrocytes for screening assays, models mimicking the human brain, and cell therapy.
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公开(公告)号：US20230399612A1
公开(公告)日：2023-12-14
申请号：US18034780
申请日：2021-11-02
Applicant: KUGELMEIERS LTD.
Inventor： Jay GOPALAKRISHNAN
CPC classification number: C12N5/0622 , G01N33/5058 , C12M23/12 , C12N2513/00 , C12N2506/03
Abstract: The present invention relates to a method for producing a plurality of homogeneous neurospheres, said method comprising: providing pluripotent cells; seeding said pluripotent cells into a cell culture device comprising at least one compartment comprising a plurality of microwells; and culturing said pluripotent cells in said cell culture device under conditions that allow the cells to form neurospheres.
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