公开(公告)号：US20180303867A1

公开(公告)日：2018-10-25

申请号：US15765449

申请日：2016-09-30

Applicant: Da Volterra

Inventor： Jean De Gunzburg ,  Mark Wilcox ,  Caroline Chilton

IPC: A61K31/731 ,  A61K33/44 ,  A61P31/04

CPC classification number: A61K31/731 ,  A61K33/44 ,  A61P31/04 ,  A61K2300/00

Abstract: The invention relates to the use of an adsorbent to reduce or suppress the pathogenicity or virulence of Clostridium bacteria in vitro, ex vivo or in vivo. The invention may be used in any mammal or environment, and is particularly effective to suppress the pathogenicity or virulence of Clostridium difficile.

公开(公告)号：US20220087945A1

公开(公告)日：2022-03-24

申请号：US17524467

申请日：2021-11-11

Applicant: Da Volterra

Inventor： Francois LESCURE ,  Jean DE GUNZBURG

IPC: A61K9/50 ,  A61K9/16 ,  A61K33/44 ,  A61K31/00 ,  A61K31/731

Abstract: The invention relates to a formulation for the delayed and controlled delivery of an adsorbent into the lower intestine of mammals. The formulation includes a carrageenan and an adsorbent, such as activated charcoal. The invention further relates to uses of this formulation, in particular to pharmaceutical uses. In one embodiment, the formulation is used to eliminate or reduce the side effects in the intestine, in particular in the colon, of pharmaceutical agents that are administered as a treatment for a disorder, but that have side effects when they reach the late ileum, the caecum or the colon.

公开(公告)号：US20210299170A1

公开(公告)日：2021-09-30

申请号：US17263783

申请日：2019-08-05

Applicant: DA VOLTERRA

Inventor： Jean DE GUNZBURG

IPC: A61K33/44 ,  A61K45/06 ,  A61K38/50 ,  A61K38/46 ,  A61P35/00 ,  A61K9/50

Abstract: The present invention relates to a method for improving the therapeutic efficacy of an anticancer agent, comprising administering to a subject in need thereof an effective amount of an adsorbent or an antibiotic-inactivating enzyme.

公开(公告)号：US20210290741A1

公开(公告)日：2021-09-23

申请号：US17263828

申请日：2019-08-05

Applicant: DA VOLTERRA

Inventor： Jean DE GUNZBURG

IPC: A61K38/50 ,  A61K33/44 ,  A61K38/46 ,  A61K47/64 ,  A61P37/06

Abstract: The present invention relates to compositions and methods for treatment or prevention of Graft-Versus-Host Disease.

公开(公告)号：US10052288B2

公开(公告)日：2018-08-21

申请号：US15641665

申请日：2017-07-05

Applicant: Da Volterra

Inventor： Francois Lescure ,  Jean De Gunzburg

IPC: A61K9/50 ,  A61K9/16 ,  A61K31/00 ,  A61K31/731 ,  A61K33/44

CPC classification number: A61K9/5073 ,  A61K9/1652 ,  A61K9/5015 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5047 ,  A61K31/00 ,  A61K31/731 ,  A61K33/44 ,  A61K2300/00

Abstract: The invention relates to a formulation for the delayed and controlled delivery of an adsorbent into the lower intestine of mammals. The formulation includes a carrageenan and an adsorbent, such as activated charcoal. The invention further relates to uses of this formulation, in particular to pharmaceutical uses. In one embodiment, the formulation is used to eliminate or reduce the side effects in the intestine, in particular in the colon, of pharmaceutical agents that are administered as a treatment for a disorder, but that have side effects when they reach the late ileum, the caecum or the colon.

公开(公告)号：US20170296478A1

公开(公告)日：2017-10-19

申请号：US15641665

申请日：2017-07-05

Applicant: Da Volterra

Inventor： Francois Lescure ,  Jean De Gunzburg

IPC: A61K9/50 ,  A61K31/731 ,  A61K31/00 ,  A61K33/44 ,  A61K9/16

CPC classification number: A61K9/5073 ,  A61K9/1652 ,  A61K9/5015 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5047 ,  A61K31/00 ,  A61K31/731 ,  A61K33/44 ,  A61K2300/00

Abstract: The invention relates to a formulation for the delayed and controlled delivery of an adsorbent into the lower intestine of mammals. The formulation includes a carrageenan and an adsorbent, such as activated charcoal. The invention further relates to uses of this formulation, in particular to pharmaceutical uses. In one embodiment, the formulation is used to eliminate or reduce the side effects in the intestine, in particular in the colon, of pharmaceutical agents that are administered as a treatment for a disorder, but that have side effects when they reach the late ileum, the caecum or the colon.