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    BETA-LACTAMASE VARIANTS
    2.
    发明申请
    BETA-LACTAMASE VARIANTS 审中-公开

    公开(公告)号：US20190062719A1

    公开(公告)日：2019-02-28

    申请号：US16078040

    申请日：2017-02-22

    Applicant: DA VOLTERRA ,  BIOASTER

    Inventor： Jean DE GUNZBURG ,  Jean-Denis DOCQUIER

    IPC: C12N9/86 ,  A61K45/06 ,  A61K38/50

    Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.

    FORMULATIONS FOR ORAL DELIVERY OF ADSORBENTS IN THE GUT
    3.
    发明申请
    FORMULATIONS FOR ORAL DELIVERY OF ADSORBENTS IN THE GUT 审中-公开

    公开(公告)号：US20180369156A1

    公开(公告)日：2018-12-27

    申请号：US16046501

    申请日：2018-07-26

    Applicant: Da Volterra

    Inventor： Francois LESCURE ,  Jean DE GUNZBURG

    IPC: A61K9/50 ,  A61K33/44 ,  A61K31/731 ,  A61K31/00 ,  A61K9/16

    Abstract: The invention relates to a formulation for the delayed and controlled delivery of an adsorbent into the lower intestine of mammals. The formulation includes a carrageenan and an adsorbent, such as activated charcoal. The invention further relates to uses of this formulation, in particular to pharmaceutical uses. In one embodiment, the formulation is used to eliminate or reduce the side effects in the intestine, in particular in the colon, of pharmaceutical agents that are administered as a treatment for a disorder, but that have side effects when they reach the late ileum, the caecum or the colon.

    FORMULATIONS FOR ORAL DELIVERY OF ADSORBENTS IN THE GUT
    4.
    发明申请
    FORMULATIONS FOR ORAL DELIVERY OF ADSORBENTS IN THE GUT 有权

    公开(公告)号：US20220087945A1

    公开(公告)日：2022-03-24

    申请号：US17524467

    申请日：2021-11-11

    Applicant: Da Volterra

    Inventor： Francois LESCURE ,  Jean DE GUNZBURG

    IPC: A61K9/50 ,  A61K9/16 ,  A61K33/44 ,  A61K31/00 ,  A61K31/731

    Abstract: The invention relates to a formulation for the delayed and controlled delivery of an adsorbent into the lower intestine of mammals. The formulation includes a carrageenan and an adsorbent, such as activated charcoal. The invention further relates to uses of this formulation, in particular to pharmaceutical uses. In one embodiment, the formulation is used to eliminate or reduce the side effects in the intestine, in particular in the colon, of pharmaceutical agents that are administered as a treatment for a disorder, but that have side effects when they reach the late ileum, the caecum or the colon.

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