公开(公告)号：US06331568B1

公开(公告)日：2001-12-18

申请号：US09284231

申请日：1999-06-10

Applicant: David Frederick Horrobin

Inventor： David Frederick Horrobin

IPC: A61K3120

CPC classification number: A61K31/202 ,  A61K31/20 ,  A61K2300/00

Abstract: A pharmaceutical preparation for the treatment of schizophrenia and/or tardive dyskinesia using an oil comprising eicosapentaenoic acid (EPA) and/or stearidonic acid (SA) in amounts of more than 20%, preferably more than 40% and very preferably more than 70% by weight of the total (preferably of the total unsaturated) fatty acids present.

Abstract translation: 使用包含二十碳五烯酸（EPA）和/或十碳十一酸（SA）的油的量超过20％，优选大于40％，优选大于70％的用于治疗精神分裂症和/或迟发性运动障碍的药物制剂， （优选总不饱和）脂肪酸的总重量。

公开(公告)号：US06245811B1

公开(公告)日：2001-06-12

申请号：US09376617

申请日：1999-08-18

Applicant: David Frederick Horrobin ,  Mehar Manku ,  Austin McMordie ,  Philip Knowles ,  Peter Redden ,  Andrea Pitt

Inventor： David Frederick Horrobin ,  Mehar Manku ,  Austin McMordie ,  Philip Knowles ,  Peter Redden ,  Andrea Pitt

IPC: A61K31225

CPC classification number: C07D213/30 ,  C07C69/007 ,  C07C69/587 ,  C07C69/76 ,  C07D209/28 ,  C07D213/66 ,  C07D233/94 ,  C07D279/36 ,  C07D321/00 ,  C07D339/04 ,  C07D499/00 ,  C07F9/091 ,  C07F9/65522 ,  C07J1/0059 ,  C07J5/0053

Abstract: Compounds of structure (I), and when for use in therapy: where R1 is an acyl group derived from a C16-30 fatty acid with two or more cis or trans double bonds and particularly an n-6 or n-3 series EFA or conjugated linoleic acid, or columbinic acid, or parinaric acid and R2 is as R1 the same or different, or any other nutrient, drug or other bioactive residue released as the active in the body and R3 is either hydrogen, fully hydrocarbon, or containing heteroatoms, preferably an alkyl group particularly a C1-C4 alkyl group.

Abstract translation: 结构（I）的化合物和用于治疗的时间：其中R1是衍生自具有两个或多个顺式或反式双键的C16-30脂肪酸的酰基，特别是n-6或n-3系列EFA或 共轭亚油酸或哥伦比酸或仲丁酸，R2为R1相同或不同的任何其它营养物质或作为活性物质释放的其他生物活性残基，R3为氢，完全烃或含杂原子 ，优选烷基，特别是C 1 -C 4烷基。