公开(公告)号：US11649475B2

公开(公告)日：2023-05-16

申请号：US17058623

申请日：2019-05-24

Applicant: NEMIS Technologies AG ,  Ramot at Tel-Aviv University Ltd.

Inventor： Doron Shabat ,  Michal Eli Roth-Konforti ,  Nir Hananya ,  Ori Green ,  Urs Spitz ,  Lukas Wick ,  Julian Ihssen ,  Raffael Vorberg ,  Riccardo Cribiu ,  Zuzana Babjakovà ,  Chunyan Yao

IPC: C07D321/00 ,  C07D407/04 ,  C12Q1/10 ,  C12Q1/04 ,  C12Q1/14 ,  C12Q1/22 ,  C12Q1/44 ,  C12Q1/54 ,  G01N21/76

CPC classification number: C12Q1/10 ,  C07D321/00 ,  C07D407/04 ,  C12Q1/04 ,  C12Q1/14 ,  C12Q1/22 ,  C12Q1/44 ,  C12Q1/54 ,  G01N21/76

Abstract: Dioxetane compounds represented by Formula I below, and methods of using the dioxetane compounds in the detection of presence or absence, quantification, and identification of microorganisms including bacteria, bacterial fragments (e.g., LPS, endotoxin), viruses, and fungi by means of chemiluminescence.

公开(公告)号：US20190144415A1

公开(公告)日：2019-05-16

申请号：US16096103

申请日：2017-05-04

Applicant: HALDOR TOPSØE A/S

Inventor： Esben TAARNING ,  Amanda Birgitte SØLVHØJ

IPC: C07D321/00 ,  C07C69/732 ,  C07C67/475

CPC classification number: C07D321/00 ,  C07B2200/09 ,  C07C67/475 ,  C07C69/732

Abstract: The present invention regards new adipate-type compounds suitable as an intermediate in organic chemistry, a platform chemical for the production of other chemicals, and as a monomer and co-monomer useful for the preparation of polymers and copolymers. The invention also regards the process of preparing the new adipate-type compounds from bio-based raw materials such as sugars.

公开(公告)号：US20170334934A1

公开(公告)日：2017-11-23

申请号：US15522132

申请日：2015-10-22

Applicant: DOW AGROSCIENCES LLC

Inventor： Kyle A. DEKORVER ,  John F. DAEUBLE, SR. ,  Johnathan E. DELORBE ,  Jeremy WILMONT ,  Chenglin YAO ,  Kevin G. MEYER

IPC: C07F7/18 ,  A01N55/00 ,  A01N43/24 ,  A01N43/40 ,  C07D405/12 ,  C07D321/00

CPC classification number: C07F7/1804 ,  A01N43/24 ,  A01N43/40 ,  A01N55/00 ,  C07D321/00 ,  C07D405/12

Abstract: This disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides.

公开(公告)号：US20170081303A1

公开(公告)日：2017-03-23

申请号：US15296164

申请日：2016-10-18

Applicant: Corsair Pharma Inc.

Inventor： Cyrus K. BECKER ,  Jürg R. PFISTER ,  Gwenaella RESCOURIO ,  Meenakshi S. VENKATRAMAN ,  Xiaoming ZHANG

IPC: C07D321/00 ,  A61K9/00 ,  A61K9/70 ,  C07C235/20 ,  A61K31/341 ,  C07C69/712 ,  A61K31/216 ,  A61K31/365 ,  C07D307/20 ,  A61K45/06 ,  A61K31/165

CPC classification number: C07D321/00 ,  A61K9/0014 ,  A61K9/7023 ,  A61K31/165 ,  A61K31/216 ,  A61K31/341 ,  A61K31/365 ,  A61K45/06 ,  C07C59/72 ,  C07C69/712 ,  C07C69/734 ,  C07C69/74 ,  C07C69/96 ,  C07C219/16 ,  C07C235/20 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/42 ,  C07C2603/14 ,  C07D207/08 ,  C07D211/60 ,  C07D257/06 ,  C07D263/24 ,  C07D263/26 ,  C07D265/30 ,  C07D295/088 ,  C07D295/145 ,  C07D307/20 ,  C07D317/34 ,  C07D317/40 ,  C07D453/02

Abstract: Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.

公开(公告)号：US09549556B2

公开(公告)日：2017-01-24

申请号：US14577956

申请日：2014-12-19

Applicant: DOW AGROSCIENCES LLC

Inventor： Kyle DeKorver ,  Johnathan E. DeLorbe ,  Kevin G. Meyer ,  Chenglin Yao ,  Ronald J. Heemstra ,  William H. Dent, III

IPC: C07D405/12 ,  C07D321/00 ,  C07F7/10 ,  A01N43/24 ,  A01N43/40 ,  A01N47/18 ,  A01N53/00

CPC classification number: A01N43/24 ,  A01N43/40 ,  A01N47/18 ,  A01N53/00 ,  C07D321/00 ,  C07D405/12

Abstract: The invention relates to macrocyclic picolinamides of Formula I and their use as fungicides.

Abstract translation: 本发明涉及式I的大环吡啶甲酰胺及其作为杀真菌剂的用途。

公开(公告)号：US20160368889A1

公开(公告)日：2016-12-22

申请号：US15157574

申请日：2016-05-18

Applicant: CORSAIR PHARMA, INC.

Inventor： Cyrus K. BECKER ,  Meenakshi s. VENKATRAMAN ,  Xiaoming ZHANG

IPC: C07D313/00 ,  C07C59/31 ,  A61K31/335 ,  A61K31/165 ,  A61K31/216 ,  C07C235/20 ,  A61K9/70

CPC classification number: C07D313/00 ,  A61K9/7023 ,  A61K31/165 ,  A61K31/216 ,  A61K31/335 ,  C07C59/31 ,  C07C59/54 ,  C07C69/712 ,  C07C69/734 ,  C07C219/16 ,  C07C235/20 ,  C07C235/34 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/42 ,  C07C2603/14 ,  C07D207/08 ,  C07D211/60 ,  C07D257/06 ,  C07D263/24 ,  C07D263/26 ,  C07D265/30 ,  C07D295/088 ,  C07D295/145 ,  C07D307/20 ,  C07D317/34 ,  C07D317/40 ,  C07D321/00 ,  C07D453/02

Abstract: Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.

公开(公告)号：US09371264B2

公开(公告)日：2016-06-21

申请号：US14153498

申请日：2014-01-13

Applicant: Corsair Pharma, Inc.

Inventor： Cyrus K. Becker ,  Jürg R. Pfister ,  Gwenaella Rescourio ,  Meenakshi S. Venkatraman ,  Xiaoming Zhang

IPC: C07C59/54 ,  C07C69/712 ,  C07D317/40 ,  C07D321/00 ,  C07D453/02 ,  C07D257/06 ,  C07D263/24 ,  C07D265/30 ,  C07D295/088 ,  C07D211/60 ,  C07D295/145 ,  C07D307/20 ,  C07C219/16 ,  C07C235/20 ,  C07C69/734 ,  C07C235/34 ,  C07D207/08 ,  C07D263/26 ,  C07D317/34

CPC classification number: C07D313/00 ,  A61K9/7023 ,  A61K31/165 ,  A61K31/216 ,  A61K31/335 ,  C07C59/31 ,  C07C59/54 ,  C07C69/712 ,  C07C69/734 ,  C07C219/16 ,  C07C235/20 ,  C07C235/34 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/42 ,  C07C2603/14 ,  C07D207/08 ,  C07D211/60 ,  C07D257/06 ,  C07D263/24 ,  C07D263/26 ,  C07D265/30 ,  C07D295/088 ,  C07D295/145 ,  C07D307/20 ,  C07D317/34 ,  C07D317/40 ,  C07D321/00 ,  C07D453/02

Abstract: Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.

公开(公告)号：US09249508B2

公开(公告)日：2016-02-02

申请号：US13609512

申请日：2012-09-11

Applicant: Mark S. Braiman

Inventor： Mark S. Braiman

IPC: C23C18/12 ,  C01B31/10 ,  C23C16/48 ,  B01D53/62 ,  C07D305/04 ,  C23C16/26 ,  C23C18/14

CPC classification number: C23C16/26 ,  B01D53/62 ,  C01B32/05 ,  C01B32/336 ,  C07D321/00 ,  C23C16/48 ,  C23C16/482 ,  C23C18/1204 ,  C23C18/1208 ,  C23C18/1245 ,  C23C18/14 ,  Y02P20/134 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T442/2992

Abstract: There is described a process for depositing carbon on a surface, comprising, while contacting a mixture of CO2 and Br2 with a polar substrate presenting apposed surfaces, exposing a sufficient area of said mixture in the region of said apposed surfaces to light of sufficient intensity and frequency to result in deposition of carbon on at least some of said apposed surfaces. Other embodiments are also described.

Abstract translation: 描述了一种在表面上沉积碳的方法，包括在将CO 2和Br 2的混合物与呈现呈现表面的极性底物接触的同时，将所述表面区域中的所述混合物的足够面积暴露于足够强度的光， 频率导致碳沉积在所述至少一些所述表面上。 还描述了其它实施例。

公开(公告)号：US20160007602A1

公开(公告)日：2016-01-14

申请号：US14793315

申请日：2015-07-07

Applicant: DOW AGROSCIENCES LLC

Inventor： Kyle A. DeKorver ,  Johnathan E. DeLorbe ,  Kevin G. Meyer ,  Chenglin Yao ,  Ron J. Heemstra ,  Karla Bravo-Altamirano ,  John F. Daeuble

IPC: A01N43/40 ,  A01N43/24 ,  C07D405/12 ,  C07D321/00

CPC classification number: A01N43/40 ,  A01N43/24 ,  C07D321/00 ,  C07D405/12

Abstract: This disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides.

公开(公告)号：US20150175883A1

公开(公告)日：2015-06-25

申请号：US14413091

申请日：2013-06-14

Applicant: Merck Patent GmbH

Inventor： Kevin Adlem ,  Owain Llyr Parri ,  Rachel Tuffin ,  Patricia Eileen Saxton ,  Mariam Namutebi ,  Benjamin Snow

IPC: C09K19/20 ,  C07C255/54 ,  C07D321/00 ,  C07C327/30 ,  C07C255/50 ,  C07C25/18 ,  C07C255/55 ,  C07C69/78 ,  C07C43/225 ,  C07D493/04

CPC classification number: C09K19/2014 ,  C07C25/18 ,  C07C43/225 ,  C07C69/78 ,  C07C255/50 ,  C07C255/54 ,  C07C255/55 ,  C07C327/30 ,  C07D321/00 ,  C07D493/04 ,  C09K19/0258 ,  C09K19/04 ,  C09K2019/0444

Abstract: The invention relates to bimesogenic compounds of formula I wherein R11, R12, MG11, MG12, X11, X12 and Sp1 have the meaning given in claim 1, to the use of bimesogenic compounds of formula I in liquid crystal media and particular to flexoelectric liquid crystal devices comprising a liquid crystal medium according to the present invention.

Abstract translation: 本发明涉及式I化合物，其中R11，R12，MG11，MG12，X11，X12和Sp1具有权利要求1中给出的含义，涉及在液晶介质中使用式I的双重制剂化合物，特别涉及柔性电液体 包括根据本发明的液晶介质的装置。