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公开(公告)号：US20240360069A1
公开(公告)日：2024-10-31
申请号：US18635874
申请日：2024-04-15
IPC分类号： C07C69/76 , C07C25/18 , C07C381/12 , C07D333/76 , C08F220/18 , C08F220/22 , G03F7/038 , G03F7/039
CPC分类号： C07C69/76 , C07C25/18 , C07C381/12 , C07D333/76 , C08F220/1806 , C08F220/1807 , C08F220/22 , G03F7/038 , G03F7/039
摘要： The present invention is a monomer represented by the following general formula (a)-1M or (a)-2M. This provides: a resist material having higher sensitivity and higher resolution than conventional positive resist materials, small edge roughness and size variation, and excellent pattern profile after exposure; a monomer to be an ingredient for the resist material; a resist composition containing the resist material; and a patterning process.
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公开(公告)号：US12018012B2
公开(公告)日：2024-06-25
申请号：US17722832
申请日：2022-04-18
IPC分类号： C07D401/12 , A61P27/06 , C07C69/76 , C07D217/02 , C07D217/22 , C07D217/24 , C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12
CPC分类号： C07D401/12 , A61P27/06 , C07C69/76 , C07D217/02 , C07D217/22 , C07D217/24 , C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12 , C07C2601/02
摘要： Provided herein are arylcyclopropyl amino-isoquinoline amide compounds. In particular, the disclosure provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the disclosure are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, diseases characterized by abnormal growth, such as cancers, and inflammatory diseases. The disclosure further provides compositions containing isoquinoline amide compounds.
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公开(公告)号：US20190248725A1
公开(公告)日：2019-08-15
申请号：US16397139
申请日：2019-04-29
发明人： Imre JUHÁSZ , Irén HORTOBÁGYI , Tamás ALTSACH , István LÁSZLÓFI , Ágnes NAGYNÉ BORKÓ , Imre ROZSUMBERSZKI , Gábor HAVASI , Zsuzsanna KARDOS , Péter BUZDER-LANTOS
IPC分类号： C07C51/347 , C07C59/72 , C07C67/14 , C07C13/547 , C07C35/37 , C07C51/41 , C07C51/09 , C07C45/65 , C07C45/30 , C07C41/26 , C07C43/315 , C07C41/48 , C07C41/30 , C07C69/76 , C07C67/293 , C07C67/29
CPC分类号： C07C51/347 , C07C13/547 , C07C35/37 , C07C41/26 , C07C41/30 , C07C41/48 , C07C43/315 , C07C45/30 , C07C45/305 , C07C45/65 , C07C51/09 , C07C51/412 , C07C59/72 , C07C67/14 , C07C67/29 , C07C67/293 , C07C69/76 , C07C2603/14 , C07C49/84 , C07C49/755 , C07C59/70
摘要： Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.
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公开(公告)号：US20190218168A1
公开(公告)日：2019-07-18
申请号：US16275165
申请日：2019-02-13
申请人： XW Laboratories Inc.
发明人： Jia-Ning Xiang , Xuesong Xu , Xuan Zhang
IPC分类号： C07C69/78 , C07D207/16 , C07C233/47 , C07C255/57 , C07C69/618 , C07C271/34 , C07C271/22 , C07D213/79 , C07C69/96 , C07C69/34 , C07D211/44 , C07D309/12 , C07D317/64 , C07D207/12 , C07C229/34 , C07C229/08 , C07D333/38 , C07D307/68 , C07D277/30 , C07D213/80 , C07C317/14 , C07C69/74 , C07C69/22 , C07C69/612
CPC分类号： C07C69/78 , C07B59/001 , C07C69/22 , C07C69/24 , C07C69/28 , C07C69/34 , C07C69/608 , C07C69/612 , C07C69/618 , C07C69/738 , C07C69/74 , C07C69/76 , C07C69/96 , C07C229/08 , C07C229/34 , C07C229/36 , C07C233/47 , C07C255/57 , C07C271/22 , C07C271/34 , C07C317/14 , C07C317/44 , C07C2601/06 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D207/12 , C07D207/16 , C07D211/44 , C07D211/46 , C07D213/79 , C07D213/80 , C07D277/30 , C07D277/56 , C07D307/68 , C07D309/12 , C07D317/64 , C07D333/38
摘要： The present disclosure discloses prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.
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公开(公告)号：US20180327381A1
公开(公告)日：2018-11-15
申请号：US15941993
申请日：2018-03-30
IPC分类号： C07D401/12 , C07D217/02 , C07D405/12 , C07D417/12 , C07D409/12 , C07D401/14 , A61P27/06
CPC分类号： C07D401/12 , A61P27/06 , C07C1/00 , C07C69/76 , C07C2601/02 , C07D217/02 , C07D217/22 , C07D217/24 , C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12
摘要： Provided herein are arylcyclopropyl amino-isoquinoline amide compounds. In particular, the disclosure provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the disclosure are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, diseases characterized by abnormal growth, such as cancers, and inflammatory diseases. The disclosure further provides compositions containing isoquinoline amide compounds.
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公开(公告)号：US20180319954A1
公开(公告)日：2018-11-08
申请号：US16029413
申请日：2018-07-06
申请人： Benjamin WOLDT , Michael Grass , Florian Boeck
发明人： Benjamin WOLDT , Michael Grass , Florian Boeck
CPC分类号： C08K5/12 , C07C67/08 , C07C67/12 , C07C69/76 , C08K5/0016
摘要： Tripentyl esters of trimellitic acid, especially mixtures of triisopentyl esters of trimellitic acid comprising isomeric pentyl radicals in which more than 5 mol % of the isomeric pentyl radicals incorporated in the ester mixture are branched, have good compatibility with PVC and PVC-containing polymers and simultaneously exhibit a lesser tendency to migrate.
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7.发明申请公开(公告)号：US20180319729A1
公开(公告)日：2018-11-08
申请号：US16030854
申请日：2018-07-09
发明人： Hongjie ZHANG , Siu Wai TSANG
IPC分类号： C07C43/23 , C07C39/16 , C07C37/00 , C07C43/215 , C07C39/21 , A61Q17/04 , C07C69/753 , C07C69/34 , A61Q19/02 , C07C69/736 , A61K31/05 , C07C43/205 , A61K8/33 , A61K8/37 , A61K8/34 , A61K31/085 , A61K31/09 , A61K9/00 , C07C39/15
CPC分类号： C07C43/23 , A61K8/33 , A61K8/347 , A61K8/37 , A61K9/0053 , A61K31/05 , A61K31/085 , A61K31/09 , A61K36/8984 , A61Q11/00 , A61Q17/005 , A61Q17/04 , A61Q19/02 , C07C37/003 , C07C39/15 , C07C39/16 , C07C39/21 , C07C43/2055 , C07C43/215 , C07C69/30 , C07C69/34 , C07C69/616 , C07C69/712 , C07C69/736 , C07C69/74 , C07C69/753 , C07C69/76 , C07C69/78 , C07C69/92 , C07C2601/08
摘要： The present invention relates to a composition for preventing or reducing microbial growth, particularly the growth of dermatophytic fungi, and/or aciduric and acidogenic gram-positive bacteria. More particularly, it relates to the use of trans-3,5,4′-trihydroxybibenzyl, also known as dihydro-resveratrol, or its dihydrostilbene derivatives and/or chemical variants as an anti-microbial agent. The present invention further relates to the management of dermatophytosis often caused by dermatophytic fungi and the management of dental caries often mediated by aciduric and acidogenic gram-positive Streptococci. The present invention therefore has applications in preventing, alleviating and/or treating dermatophytosis and dental caries.
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公开(公告)号：US20180215740A1
公开(公告)日：2018-08-02
申请号：US15746029
申请日：2016-07-13
申请人： BASF SE
发明人： Gopal Krishna Datta , Pascal Bindschaedler , Wolfgang von Deyn , Michael Rack , Karsten Koerber
IPC分类号： C07D409/12 , A01N43/54 , A01N43/40 , C07D333/24 , A01N43/10 , A01N43/20 , C07D413/12 , A01N43/80 , C07D261/04 , C07D403/12 , C07D207/20 , A01N43/36 , C07D417/12 , A01N43/78
CPC分类号： C07D409/12 , A01N43/10 , A01N43/20 , A01N43/36 , A01N43/40 , A01N43/54 , A01N43/78 , A01N43/80 , C07C47/55 , C07C63/72 , C07C67/30 , C07C69/76 , C07C2602/08 , C07C2602/10 , C07D207/20 , C07D261/04 , C07D333/24 , C07D403/12 , C07D413/12 , C07D417/12
摘要： Compounds of formula I and formula II their intermediates, as well as processes for the preparation of compounds of formula I and formula II, are disclosed. Use of compounds of formula I for the production of compounds of formula VI is also disclosed. Additionally, the use of compounds of formula I or formula II for the production of active compounds is disclosed.
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公开(公告)号：US20180168970A1
公开(公告)日：2018-06-21
申请号：US15735755
申请日：2016-06-10
申请人： ISP INVESTMENTS LLC.
发明人： Ilya MAKAROVSKY , Michael A. Tallon , Hani M. Fares , Donald I. Prettypaul , Krishnamurthy Nacharaju , Anna A. Gripp , Osama M. Musa
CPC分类号： A61K8/37 , A61K8/4966 , A61K2800/262 , A61K2800/49 , A61P17/16 , A61Q17/04 , C07C69/76 , C07C2601/08 , C07C2601/14
摘要： A photo protective topical composition, comprising: (i) at least one functional active; and (ii) at least one solubilizing compound having the structure of Formula I: wherein R is C5-C10 cycloalkyl or linear or branched alkylcycloalkyl, wherein the ring size is C5-C7; R1, R2, and R3 are each independently selected from the group consisting of H, and linear or branched C1-C4 alkyl, provided that at least two of R1, R2, R3 are H; wherein the solubilizing compound is present in an amount effective to solubilize said functional active. Also disclosed is a method for treating skin, lips, nails, hair, ears, eyelashes, eyebrows and/or scalp with an effective amount of composition.
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公开(公告)号：US20180134660A1
公开(公告)日：2018-05-17
申请号：US15573290
申请日：2016-04-22
发明人： Ramesh Dandala , Sureshbabu Jayachandra , Vipin Kumar Kaushik , Nageshwara Rao Achanta , Sivaprasad Dorasala
IPC分类号： C07D209/48 , C07C315/04
CPC分类号： C07D209/48 , C07B2200/07 , C07C69/76 , C07C311/19 , C07C315/04 , C07C315/06 , C07C317/28
摘要： A process for the resolution of racemic 2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylamine using novel chiral salts is disclosed. An L-phenylalanine p-toluene-sulfonamide salt of (S)-2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylamine and a di-p-toluoyl-L-tartaric acid salt of (S)-2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylamine are also provided.
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