公开(公告)号：US20100234386A1

公开(公告)日：2010-09-16

申请号：US12599544

申请日：2008-05-08

Applicant: Amita Chaudhari ,  Dashyant Dhanak ,  Carla Ann Donatelli ,  Thomas H. Faitg ,  Yanhong Feng ,  Steven David Knight ,  Cynthia A. Parrish ,  Jeffrey M. Ralph ,  Martha A. Sarpong ,  Domingos J. Silva

Inventor： Amita Chaudhari ,  Dashyant Dhanak ,  Carla Ann Donatelli ,  Thomas H. Faitg ,  Yanhong Feng ,  Steven David Knight ,  Cynthia A. Parrish ,  Jeffrey M. Ralph ,  Martha A. Sarpong ,  Domingos J. Silva

IPC: A61K31/498 ,  C07D401/02 ,  A61P29/00 ,  A61P9/00 ,  A61P25/00 ,  A61P11/06 ,  A61P13/12 ,  A61P35/00 ,  A61P15/00

CPC classification number: C07D471/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D417/14

Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoxaline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoxaline derivatives.

Abstract translation: 发明的是使用喹喔啉衍生物抑制PI3激酶活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法：自身免疫性疾病，炎性疾病，心血管疾病，神经变性疾病，变态反应，哮喘，胰腺炎，多器官功能衰竭，肾脏疾病，血小板聚集，癌症，精子活力，移植排斥反应， 通过施用喹喔啉衍生物的移植排斥和肺部损伤。

公开(公告)号：US07629477B2

公开(公告)日：2009-12-08

申请号：US12142621

申请日：2008-06-19

Applicant: Andrew McDonald ,  Gustave Bergnes ,  Bainian Feng ,  David J. Morgans, Jr. ,  Steven David Knight ,  Kenneth A. Newlander ,  Dashyant Dhanak ,  Christopher A. Brook

Inventor： Andrew McDonald ,  Gustave Bergnes ,  Bainian Feng ,  David J. Morgans, Jr. ,  Steven David Knight ,  Kenneth A. Newlander ,  Dashyant Dhanak ,  Christopher A. Brook

IPC: C07D311/22

CPC classification number: C07D405/06 ,  C07D311/22 ,  C07D311/36 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

公开(公告)号：US20090181027A1

公开(公告)日：2009-07-16

申请号：US12238804

申请日：2008-09-26

Applicant: Paul Dal Monte ,  Jill Giles-Komar ,  George Heavner ,  David Knight ,  Mehrnaz Khossravi ,  Jinquan Luo ,  David Shealy ,  David Volkin

Inventor： Paul Dal Monte ,  Jill Giles-Komar ,  George Heavner ,  David Knight ,  Mehrnaz Khossravi ,  Jinquan Luo ,  David Shealy ,  David Volkin

IPC: A61K39/395 ,  A61P43/00

CPC classification number: A61K47/26 ,  A61K47/183 ,  A61K2039/505 ,  C07K16/244 ,  C07K2317/34 ,  C07K2317/76

Abstract: An anti-IL-12/23p40 antibody that binds to a portion of the IL-12 or IL-23 protein corresponding to the p40 subunit of IL-12 or IL-23, including compositions, formulations, and methods of administration have applications in diagnostic and/or therapeutic uses and devices.

Abstract translation: 结合与IL-12或IL-23的p40亚基相对应的IL-12或IL-23蛋白的一部分的抗IL-12 / 23p40抗体，包括组合物，制剂和施用方法，可应用于 诊断和/或治疗用途和装置。

公开(公告)号：US20090082349A1

公开(公告)日：2009-03-26

申请号：US12281187

申请日：2007-03-02

Applicant: Dashyant Dhanak ,  Steven David Knight

Inventor： Dashyant Dhanak ,  Steven David Knight

IPC: A61K31/5377 ,  A61K31/517 ,  A61K31/502 ,  A61P37/00 ,  A61P29/00 ,  A61P9/00 ,  A61P25/00 ,  A61P35/00

CPC classification number: A61K31/5377

Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.

公开(公告)号：US20090048252A1

公开(公告)日：2009-02-19

申请号：US12281181

申请日：2007-03-02

Applicant: Dashyant Dhanak ,  Steven David Knight

Inventor： Dashyant Dhanak ,  Steven David Knight

IPC: A61K31/427 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/454

CPC classification number: A61K31/5377

Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.

公开(公告)号：US20090023742A1

公开(公告)日：2009-01-22

申请号：US12281179

申请日：2007-03-02

Applicant: Dashyant Dhanak ,  Steven David Knight

Inventor： Dashyant Dhanak ,  Steven David Knight

IPC: A61K31/498 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/433 ,  A61K31/4245 ,  A61K31/496 ,  A61P29/00 ,  A61P25/00 ,  A61P11/06 ,  A61P19/02 ,  A61P13/12 ,  A61P35/00 ,  A61P9/00 ,  A61P37/02 ,  A61K31/437 ,  A61K31/454 ,  A61K31/428 ,  A61K31/4709

CPC classification number: A61K31/496

Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.

Abstract translation: 发明了使用取代的噻唑啉酮抑制PI3激酶活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法：自身免疫性疾病，炎性疾病，心血管疾病，神经变性疾病，变态反应，哮喘，胰腺炎，多器官功能衰竭，肾脏疾病，血小板聚集，癌症，精子活力，移植排斥反应， 通过施用取代的噻唑啉酮的移植物排斥和肺损伤。

公开(公告)号：US20080255115A1

公开(公告)日：2008-10-16

申请号：US11844404

申请日：2007-08-24

Applicant: Michael Gerard Darcy ,  Steven David Knight ,  Nicholas D. Adams ,  Stanley J. Schmidt

Inventor： Michael Gerard Darcy ,  Steven David Knight ,  Nicholas D. Adams ,  Stanley J. Schmidt

IPC: C07D401/14 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  C07D413/14 ,  A61K31/5377 ,  A61P35/00

CPC classification number: C07D417/14

Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using thiazolidinedione derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of thiazolidinedione derivatives.

Abstract translation: 本发明是使用噻唑烷二酮衍生物抑制PI3激酶的活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法：自身免疫性疾病，炎性疾病，心血管疾病，神经变性疾病，变态反应，哮喘，胰腺炎，多器官功能衰竭，肾脏疾病，血小板聚集，癌症，精子活力，移植排斥反应， 通过施用噻唑烷二酮衍生物的移植排斥和肺损伤。

公开(公告)号：US20080168437A1

公开(公告)日：2008-07-10

申请号：US11625725

申请日：2007-01-22

Applicant: Weidong Chen ,  Lei Zhu ,  Min Zhu ,  Chris Kangas ,  Matthew Sheppard ,  David Knight

Inventor： Weidong Chen ,  Lei Zhu ,  Min Zhu ,  Chris Kangas ,  Matthew Sheppard ,  David Knight

IPC: G06F9/445

CPC classification number: H04N7/15 ,  G06F21/6218 ,  G06F2221/2141

Abstract: In one embodiment, the methods and apparatuses request an installation of an application; detect a user requesting the application; detect a profile associated with the user; and grant permission to install the application based on an installation permission.

Abstract translation: 在一个实施例中，所述方法和装置请求安装应用程序; 检测请求应用的用户; 检测与用户相关联的简档; 并根据安装权限授予安装应用程序的权限。

公开(公告)号：US20080165391A1

公开(公告)日：2008-07-10

申请号：US11625704

申请日：2007-01-22

Applicant: Weidong Chen ,  Lei Zhu ,  Min Zhu ,  Chris Kangas ,  Matthew Sheppard ,  David Knight

Inventor： Weidong Chen ,  Lei Zhu ,  Min Zhu ,  Chris Kangas ,  Matthew Sheppard ,  David Knight

IPC: H04N1/387

CPC classification number: H04N7/15 ,  G06F21/6218 ,  G06F2221/2141

Abstract: In one embodiment, the methods and apparatuses request an application; detect a user requesting the application; detect a profile associated with the user; and grant permission to access the application based on an access parameter.

Abstract translation: 在一个实施例中，所述方法和装置请求应用; 检测请求应用的用户; 检测与用户相关联的简档; 并基于访问参数授予访问应用程序的权限。

公开(公告)号：US20080066071A1

公开(公告)日：2008-03-13

申请号：US11853782

申请日：2007-09-11

Applicant: Sandeep Jain ,  David Knight

Inventor： Sandeep Jain ,  David Knight

IPC: G06F9/46 ,  G06F17/50

CPC classification number: G06Q10/06

Abstract: Techniques are provided for capturing the ID of a work item, and the corresponding effort level information, as a part of the actual check-in process of the artifacts into the underlying change management system. This effort information can then be propagated to an external system for subsequent reporting and analysis. In one embodiment, tasks (or similar items such as issues or bugs) are entered into a common task or issue tracking system. As part of this process each task is assigned a unique identifier. A “call-out” is added to the source control management system which captures the effort level and task ID associated with the proposed change. The data entered is validated to ensure that the task ID is valid and that the effort entered is within a valid range. If the data entered is valid, the change to the underlying artifact is allowed to proceed and the effort and task information is stored for later analysis. If the data is not valid, the proposed change is rejected and an appropriate error message is returned to the user.

Abstract translation: 提供技术用于捕获工作项目的ID以及对应的努力水平信息，作为工件进入基础变更管理系统的实际登入过程的一部分。 然后可以将此工作信息传播到外部系统进行后续报告和分析。 在一个实施例中，将任务（或诸如问题或错误的类似项目）输入到公共任务或问题跟踪系统中。 作为此过程的一部分，每个任务都被分配唯一的标识符。 在源控制管理系统中添加“呼出”，其捕获与所提出的改变相关联的努力水平和任务ID。 验证输入的数据，以确保任务ID有效，输入的工作量在有效范围内。 如果输入的数据有效，则允许对基础工件进行更改，并保存工作量和任务信息以供以后分析。 如果数据无效，则建议的更改被拒绝，并向用户返回适当的错误消息。